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Quiz: Insulin use
Ans: Insulin is used to treat all patients with type 1 and many with type 2 diabetes.
consists of two amino acid chains (a acidic and b basic) linked by two disulfide bridges. it is
synthesized in the pancreas by b ce;;s within islets of langerhans. insulin is released by rise
in blood sugar (eating a. meal).
Anaolic reaction (insulin promotes conservation of energy and buildup of energy stores)
Quiz: Insulin metabolic actions
Ans: Insulin promotes glucose into glycogen, amino acids assembled into proteins, fatty
acids into triglycerides.
Insulin deficiency promotes glycogen into glucose, proteins into amino acids, and fats into
glycerol.
Quiz: Metformin use
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, Ans: Biguanide
used for type 2 DM. oral anti diabetic. may be used with other drugs. can be used for
prevention of type 2 diabetes, GDM, PCOS.
Reduces GI absorbance of glucose and hepatic production of glucose. Does not stimulate
insulin release from the pancreas.
Increases HDL, decreases BP, promotes weight loss.
Quiz: DPP-4 Inhibitors (gliptins)
Ans: go to pancreas and increase insulin release.
Example is Sitaglitpin
Quiz: Sodium Glucose cotransporter 2 inhibitors (SGLT-2 inhibitors). (gliflozins)
Ans: Example: empagliflozin
increases urine excretion of glucose, taken PO, reduces cardiovascular risk of type 2
diabetes.
SE: yeast infections and genital gangrene
Quiz: Incretin Mimetics ('tides)
Ans: injectables that slow gastric emptying, causes weight loss and help an overwhelmed
pancreas.
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, Quiz: solfonylureas
Ans: stimulate pancreas to release more insulin. range in onset, duration, and potency
and are only used for type 2 diabetes. there are first generation and second generation.
second are more potent and doses are lower and drug drug interactions are less common
AE: hypoglycemia
Quiz: Acarbose
Ans: a glucosidase inhibitor
oral anti diabetic agent that inhibits breakdown of oligosaccharides into monosaccharides.
this delays digestion and prolongs absorption of carbs and decreases postprandial
hyperglycemia!!
ADR: FI upset and flatulence.
take this with first bite of each meal.
Quiz: Insulin Complications/ Drug Interactions
Ans: hypoglycemia caused by overdose.
hypoglycemic agents (sulfonylureas, glinides, and alcohol), hyperglycemia agents, b
adrenergic blocking agents.
Quiz: Sitagliptin
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