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What can you tell a colleague about drug-supplement interactions? -
🧠ANSWER ✔✔The elderly population may be at the greatest risk for a
potential interaction
What is an example of a pharmacokinetic interaction? - 🧠ANSWER
✔✔Orange juice inhibits OATP in the gut which might decrease the
absorption of fexofenadine
Based on the system for evaluating the significance of drug-supplement
interactions described in this course, what would the overall rating be for an
interaction that is "probable" and has "moderate" severity? - 🧠ANSWER
✔✔Moderate
What is the best way to prevent an interaction between grapefruit and CYP
3A4 substrates? - 🧠ANSWER ✔✔Avoid grapefruit and grapefruit products
when taking CYP 3A4 substrate drugs
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,A transplant patient stabilized on cyclosporine mentions to his healthcare
provider that he feels depressed. He wants to try St. John's Wort. How
would you counsel this patient? - 🧠ANSWER ✔✔Do not take St. John's
Wort
A 32-year old female asks you if she should take an allicin-rich garlic
supplement for lowering cholesterol. Her current medications include an
oral contraceptive, ibuprofen as needed for menstrual discomfort, and
calcium. what would you recommend for this patient? - 🧠ANSWER ✔✔Use
a backup form of birth control while taking allicin-rich garlic
A patient was prescribed ciprofloxacin for a lower respiratory tract infection.
She has heard that some people drink tea and honey to battle similar
infections. She doesn't like drinking tea but she is planning to start taking
green tea capsules instead. How would you counsel this patient? -
🧠ANSWER ✔✔Do not take the green tea supplement, and do not drink
green tea while taking ciprofloxacin
Which is a clinically significant drug-supplement interaction? - 🧠ANSWER
✔✔St. John's wort and cyclosporine
An overweight patient with diabetes is interested in trying the supplement
garcinia to help him lose weight. He currently takes aspirin, glyburide,
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, citalopram, simvastatin, and benazepril. Which combination might result in
a significant interaction? - 🧠ANSWER ✔✔Garcinia and citalopram
A 72 yo female recently had a PCI and is taking aspirin and clopidogrel in
addition to other medications. She wants to buy a supplement containing
ginkgo, garlic, astragalus, or dong quai. Which herb can the patient take
safely with clopidogrel and aspirin? - 🧠ANSWER ✔✔Astragalus
What are the symptoms of depression? - 🧠ANSWER ✔✔Difficulty making
decisions, fatigue, and overeating
What can you tell a colleague about scales used to measure depression -
🧠ANSWER ✔✔Having a better score on the Hamilton Rating Scale for
Depression doesn't always mean superior antidepressant effects
Which natural medicines have been shown to improve depression? -
🧠ANSWER ✔✔St. John's wort and SAMe
What is a concern about the use of St. John's wort? - 🧠ANSWER ✔✔There
is potential for a large number of drug interactions
What can you tell patients about using SAMe for depression? - 🧠ANSWER
✔✔SAMe is a costly dietary supplement
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