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Terms in this set (41)
The stem cell divides, producing undifferentiated myeloid or lymphoid
stem cells that are of what lineage?
What cells do myeloid precursors turn into? red blood cells, white blood cells, and platelets
What cells do lymphoid precursors turn into? specialized white blood cells called lymphocytes
Granulocytes are basophils, eosinophils, neutrophils
Agranuloyctes are T lymphocytes, B lymphocytes, monocytes
What two type of immunity make up the immune innate and adaptive
system?
What line of defense is innate immunity? first
What is the role of innate immunity? is to mount a non-specific response to a non-self entity that does not retain
memory of the entity
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What types of things does innate immunity respond skin, mucous membranes, normal flora of the skin and gut as barrier or
to? bacterial protection against foreign substances AND cellular components
such as phagocytes, natural killer cells, granulocytes, and macrophages
If innate immunity proves to be insufficient, what is adaptive immunity
mobilized?
Adaptive immunity leads to what? immune system memory related to a pathogen or foreign substance
What are the three parts of adaptive immunity? humoral immunity, cell mediated immunity, regulatory t-cells
What is humoral immunity made up of? b lymphocytes, memory b cells, and plasma to produce immunoglobulins
or antibodies
What is cell mediated immunity dependent on? cytotoxic t-cells, helper t-cells and their cytokines
What are regulatory t-cells also known as? supressor t-cells
What do regulatory t-cells do? regulate the immune response to prevent autoimmune reactions and limit
inflammatory responses
What are cytokines? cytokines are secreted by lymphocytes with the intention of stimulating
macrophages and cytotoxic t lymphocytes to identify and kill pathogen
infected cells or tumor cells
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What do proto-oncogenes do? regulate normal cell growth and division.
What are proto-oncogenes? they are a large family of genes that code for proteins and enzymes that
turn on the cell cycle
If a mistake in copies of DNA occur next to a porto- oncogene
oncogene, it can "turn on" and become what?
What are two examples of an oncogene? EGFR/Erb- B1 and Erb-B2/HER2
What is a very important tumor suppressor gene? p53
What is the p53 gene also called? suicide gene
What does neoadjuvant therapy refer to? treatment given as a first step to shrink a tumor before the main treatment
What is adjuvant therapy? additional cancer treatment given after the primary treatment to lower the
risk that cancer will occur
How do alkylating agents function? by causing a break in the DNA helix strand, causing interference with DNA
replication, which results in cell death
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