Advanced Pathophysiology
Midterms Exam Review (Qns & Ans)
2025
1. Which of the following is the primary mechanism of action
for angiotensin-converting enzyme (ACE) inhibitors in the
treatment of hypertension?
- A. Inhibition of renin release
- B. Blockade of angiotensin II receptors
- C. Inhibition of angiotensin I conversion to angiotensin II
- D. Stimulation of aldosterone secretion
- ANS: C. Inhibition of angiotensin I conversion to
angiotensin II
©2025
, - Rationale: ACE inhibitors prevent the conversion of
angiotensin I to angiotensin II, a potent vasoconstrictor, thereby
reducing blood pressure.
2. Which of the following conditions is characterized by the
presence of Reed-Sternberg cells?
- A. Non-Hodgkin lymphoma
- B. Hodgkin lymphoma
- C. Multiple myeloma
- D. Chronic lymphocytic leukemia
- ANS: B. Hodgkin lymphoma
- Rationale: Reed-Sternberg cells are a hallmark of Hodgkin
lymphoma and are used to differentiate it from other types of
lymphomas.
3. What is the most common cause of acute pancreatitis?
- A. Alcohol abuse
- B. Gallstones
- C. Hypertriglyceridemia
- D. Viral infections
- ANS: B. Gallstones
©2025
, - Rationale: Gallstones are the most common cause of acute
pancreatitis, leading to obstruction of the pancreatic duct and
subsequent inflammation.
4. Which of the following is a characteristic feature of nephrotic
syndrome?
- A. Hematuria
- B. Proteinuria
- C. Pyuria
- D. Bacteriuria
- ANS: B. Proteinuria
- Rationale: Nephrotic syndrome is characterized by
significant proteinuria, hypoalbuminemia, and edema.
5. Which of the following is the primary pathophysiological
mechanism in chronic obstructive pulmonary disease (COPD)?
- A. Airway hyperresponsiveness
- B. Alveolar destruction
- C. Pulmonary embolism
- D. Pleural effusion
- ANS: B. Alveolar destruction
©2025