TEST BANK
PATHOPHYSIOLOGY
The Biologic Basis For Disease In
Adults And Children
8TH EDITION BY KATHRYN L.
MCCANCE
,McCance:65Pathophysiology:65The65Biologic65Basis65for65Disease65in65Adults65and65Children65(8th65Edi
tion)65TEST65BANK
CONTENTS:
Chapter6501:65Cellular65Biology
Chapter6502:65Altered65Cellular65and65Tissue65Biology:65Environmental65Agents
Chapter6503:65The65Cellular65Environment:65Fluids65and65Electrolytes,65Acids65and65Bases
Chapter6504:65Genes65and65Genetic65Diseases
Chapter6505:65Genes,65Environment-Lifestyle,65and65 Common65Diseases
Chapter6506:65Epigenetics65and65Disease
Chapter6507:65Innate65Immunity:65Inflammation65and65Wound65Healing
Chapter6508:65Adaptive65Immunity
Chapter6509:65Alterations65in65Immunity65and65Inflammation
Chapter6510:65Infection
Chapter6511:65Stress65and65Disease
Chapter6512:65Cancer65Biology
Chapter6513:65Cancer65Epidemiology
Chapter6514:65Cancer65in65Children
Chapter6515:65Structure65and65Function65of65the65Neurologic65System
Chapter6516:65Pain,65Temperature65Regulation,65Sleep,65and65Sensory65Function
Chapter6517:65Alterations65in65Cognitive65Systems,65Cerebral65Hemodynamics,65and65Motor65Function
Chapter6518:65Disorders65of65the65Central65and65Peripheral65Nervous65Systems65and65the65Neuromuscular65Juncti
on
Chapter6519:65Neurobiology65of65Schizophrenia,65Mood65Disorders,65and65Anxiety65Disorders
Chapter6520:65Alterations65of65Neurologic65Function65in65Children
Chapter6521:65Mechanisms65of65Hormonal65Regulation
Chapter6522:65Alterations65of65Hormonal65Regulation
Chapter6523:65Obesity65and65Disorders65of65Nutrition
Chapter6524:65Structure65and65Function65of65the65Reproductive65Systems
Chapter6525:65Alterations65of65the65Female65Reproductive65System
Chapter6526:65Alterations65of65the65Male65Reproductive65System
Chapter6527:65Sexually65Transmitted65Infections
Chapter6528:65Structure65and65Function65of65the65Hematologic65System
Chapter6529:65Alterations65of65Erythrocytes,65Platelets,65and65Hemostatic65Function
Chapter6530:65Alterations65of65Leukocyte65and65Lymphoid65Function
Chapter6531:65Alterations65of65Hematologic65Function65in65Children
Chapter6532:65Structure65and65Function65of65the65Cardiovascular65and65Lymphatic65Systems
Chapter6533:65Alterations65of65Cardiovascular65Function
Chapter6534:65Alterations65of65Cardiovascular65Function65in65Children
Chapter6535:65Structure65and65Function65of65the65Pulmonary65System
Chapter6536:65Alterations65of65Pulmonary65Function
Chapter6537:65Alterations65of65Pulmonary65Function65in65Children
Chapter6538:65Structure65and65Function65of65the65Renal65and65Urologic65Systems
Chapter6539:65Alterations65of65Renal65and65Urinary65Tract65Function
Chapter6540:65Alterations65of65Renal65and65Urinary65Tract65Function65in65Children
Chapter6541:65Structure65and65Function65of65the65Digestive65System
Chapter6542:65Alterations65of65Digestive65Function
Chapter6543:65Alterations65of65Digestive65Function65in65Children
Chapter6544:65Structure65and65Function65of65the65Musculoskeletal65System
Chapter6545:65Alterations65of65Musculoskeletal65 Function
Chapter6546:65Alterations65of65Musculoskeletal65Function65in65Children
Chapter6547:65Structure,65Function,65and65Disorders65of65the65Integument
Chapter6548:65Alterations65of65the65Integument65in65Children
Chapter6549:65Shock,65Multiple65Organ65Dysfunction65Syndrome,65and65Burns65in65Adults
Chapter6550:65Shock,65Multiple65Organ65Dysfunction65Syndrome,65and65Burns65in65Children
, (8th6 5 Children
McCance:6 5 Pathophysiology:6 5 The6 5 Biologic6 5 Basis6 5 for6 5 Disease6 5 in6 5 Adults6 5 and
Edition)6 5 TEST6
5B
Part651:65CENTRAL65CONCEPTS65OF65PATHOPHYSIOLOGY:65CELLS65AND65TISS
UES65Unit65I:65THE65CELL
CHAPTER6501:65CELLULAR65BIOLOGY
MULTIPLE65CHOICE
1. Which65statement65best65describes65the65cellular65function65of65metabolic65absorption?
a. Cells65can65produce65proteins.
b. Cells65can65secrete65digestive65enzy
mes.
c. Cells65can65take65in65and65use65nutri
ents.
d. Cells65can65synthesize65fats.
ANS:65 C
In65metabolic65absorption,65all65cells65take65in65and65use65nutrients65and65other65substances65fro
m65their65surroundings.65The65remaining65options65are65not65inclusive65in65their65descriptions65of
65cellular65metabolic65absorption.
PTS:6 5 6 5 1 DIF: Cognitive65Level:65Remembering
2. Where6 5 is6 5 most6 5 of6 5 a6 5 cell’s6 5 genetic6 5 information,6 5 including6 5 RNA6 5 and6 5 DNA,6 5 contained
?
a. Mitochondria
b. Ribosome
c. Nucleolus
d. Lysosome
ANS:6 5 C
The6 5 nucleus6 5 contains6 5 the6 5 nucleolus,6 5 a6 5 small6 5 dense6 5 structure6 5 composed6 5 largely6
5 of6 5 RNA,6 5 mos65t6 5 of6 5 the6 5 cellular6 5 DNA,6 5 and6 5 the6 5 DNA-
binding6 5 proteins,6 5 such6 5 as6 5 the6 5 histones,6 5 which6 5 regulate6 5 its6 5 activity.6 5 The6 5 mitoc
hondria6 5 are6 5 res65ponsible6 5 for6 5 cellular6 5 respiration6 5 and6 5 energy6 5 production.
Ribosomes’65chief65function6 5 is6 5 to65provide6 5 sites6 5 for65cellular65protein6 5 synthesis.6 5 Lysos
omes6 5 functi65on6 5 as6 5 the6 5 intracellular6 5 digestive6 5 system.
PTS: 1 DIF: Cognitive6 5 Level:6 5 Remembering
3. Which6 5 component6 5 of6 5 the6 5 cell6 5 produces6 5 hydrogen6 5 peroxide6 5 (H2O2)6 5 by65using6
5 oxygen6 5 to6 5 re65move6 5 hydrogen6 5 atoms6 5 from6 5 specific6 5 substrates6 5 in6 5 an6 5 oxida
tive6 5 reaction?
a. Lysosomes
b. Peroxisomes
c. Ribosomes
d. Endosome
ANS:6 5 B
, (8th6 5 Children
McCance:6 5 Pathophysiology:6 5 The6 5 Biologic6 5 Basis6 5 for6 5 Disease6 5 in6 5 Adults6 5 and
Edition)6 5 TEST6
5B
Peroxisomes6 5 are6 5 so6 5 named6 5 because6 5 they6 5 usually6 5 contain6 5 enzymes6 5 that6 5 use6 5 o
xygen6 5 to6 5 remo65ve6 5 hydrogen6 5 atoms6 5 from6 5 specific6 5 substrates6 5 in6 5 an6 5 oxidative6 5 r
eaction6 5 that6 5 produces6 5 H2O2,6 5 wh65ich6 5 is6 5 a6 5 powerful6 5 oxidant6 5 and6 5 potentially6 5 de
structive6 5 if6 5 it6 5 accumulates6 5 or6 5 escapes6 5 from6 5 pero65xisomes.
Ribosomes6 5 are6 5 RNA-
protein6 5 complexes6 5 (nucleoproteins)6 5 that6 5 are6 5 synthesized6 5 in6 5 the6 5 nucleolus6 5 and6 5 s
ecreted6 5 into6 5 t65he6 5 cytoplasm6 5 through6 5 pores6 5 in6 5 the6 5 nuclear6 5 envelope6 5 called6 5 nu
clear6 5 pore6 5 complexes.6 5 Lysoso65mes6 5 are6 5 saclike6 5 structures6 5 that6 5 originate6 5 from6 5 t
he6 5 Golgi6 5 complex6 5 and6 5 contain6 5 more6 5 than6 5 4065digestive6 5 enzymes6 5 called6 5 hydrol
ases,6 5 which6 5 catalyze6 5 bonds6 5 in6 5 proteins,6 5 lipids,6 5 nucleic6 5 acids
,6 5 and6 5 carbohydrates.6 5 An6 5 endosome6 5 is6 5 a6 5 vesical6 5 that6 5 has6 5 been6 5 pinched6 5 off6
5 from6 5 the6 5 cellular65membrane.
PTS: 1 DIF: Cognitive6 5 Level:6 5 Remembering
4. Which6 5 cell6 5 component6 5 is6 5 capable6 5 of6 5 cellular6 5 autodigestion6 5 when6 5 it6 5 is6 5 released6 5 durin
g6 5 cell6 5 injury?
a. Ribosome
b. Golgi6 5 complex
c. Smooth65 endoplasmic65 reticu
lu65m
d. Lysosomes
ANS:6 5 D
The6 5 lysosomal6 5 membrane6 5 acts6 5 as6 5 a6 5 protective6 5 shield6 5 between6 5 the6 5 powerful6 5 d
igestive6 5 enzym65es65within65the65lysosome65and65the65cytoplasm,65preventing65their65leakage6
5into65the65cytoplasmic65m6 5 atrix.6 5 Disruption6 5 of6 5 the6 5 membrane6 5 by6 5 various6 5 treatme
nts6 5 or6 5 cellular6 5 injury6 5 leads6 5 to6 5 a6 5 releas65e65of65the65lysosomal65enzymes,65which65ca
n65then65react65with65their65specific65substrates,65causing65ce6 5 llular6 5 self-
digestion.6 5 The6 5 chief6 5 function6 5 of6 5 a6 5 ribosome6 5 is6 5 to6 5 provide6 5 sites6 5 for6 5 cellular6 5 protein6
5 synthesis
.6 5 The6 5 Golgi6 5 complex6 5 is6 5 a6 5 network6 5 of6 5 flattened,6 5 smooth6 5 vesicles6 5 and6 5 membra
nes6 5 often6 5 locate65d6 5 near6 5 the6 5 cell6 5 nucleus.6 5 The6 5 smooth6 5 endoplasmic6 5 reticulum6
5 is6 5 involved6 5 in6 5 steroid6 5 hormone65production6 5 and6 5 removing6 5 toxic6 5 substances6 5 fro
m6 5 the6 5 cell.
PTS: 1 DIF: Cognitive6 5 Level:6 5 Remembering
5. Which6 5 cAMP-mediated6 5 response6 5 is6 5 related6 5 to6 5 antidiuretic6 5 hormone?
a. Increased6 5 heart6 5 rate6 5 and6 5 force65of6 5 c
ontracti65on
b. Secretion6 5 of6 5 cortisol
c. Increased6 5 retention6 5 of6 5 water
d. Breakdown6 5 of6 5 fat
ANS:6 5 C
Antidiuretic6 5 hormone6 5 leads6 5 to6 5 increased6 5 retention6 5 of6 5 water6 5 in6 5 the6 5 body.6 5 Epin
ephrine6 5 causes65increases6 5 in6 5 heart6 5 rate6 5 and6 5 force6 5 of6 5 contraction.6 5 Increased6 5 cor
tisol6 5 secretion6 5 is6 5 due6 5 to6 5 ACT
H.6 5 Breakdown6 5 of6 5 fat6 5 is6 5 due6 5 to6 5 glucagon.
PTS: 1 DIF: Cognitive6 5 Level:6 5 Remembering
6. During6 5 which6 5 phase6 5 of6 5 the6 5 cell6 5 cycle6 5 is6 5 DNA6 5 synthesized?
PATHOPHYSIOLOGY
The Biologic Basis For Disease In
Adults And Children
8TH EDITION BY KATHRYN L.
MCCANCE
,McCance:65Pathophysiology:65The65Biologic65Basis65for65Disease65in65Adults65and65Children65(8th65Edi
tion)65TEST65BANK
CONTENTS:
Chapter6501:65Cellular65Biology
Chapter6502:65Altered65Cellular65and65Tissue65Biology:65Environmental65Agents
Chapter6503:65The65Cellular65Environment:65Fluids65and65Electrolytes,65Acids65and65Bases
Chapter6504:65Genes65and65Genetic65Diseases
Chapter6505:65Genes,65Environment-Lifestyle,65and65 Common65Diseases
Chapter6506:65Epigenetics65and65Disease
Chapter6507:65Innate65Immunity:65Inflammation65and65Wound65Healing
Chapter6508:65Adaptive65Immunity
Chapter6509:65Alterations65in65Immunity65and65Inflammation
Chapter6510:65Infection
Chapter6511:65Stress65and65Disease
Chapter6512:65Cancer65Biology
Chapter6513:65Cancer65Epidemiology
Chapter6514:65Cancer65in65Children
Chapter6515:65Structure65and65Function65of65the65Neurologic65System
Chapter6516:65Pain,65Temperature65Regulation,65Sleep,65and65Sensory65Function
Chapter6517:65Alterations65in65Cognitive65Systems,65Cerebral65Hemodynamics,65and65Motor65Function
Chapter6518:65Disorders65of65the65Central65and65Peripheral65Nervous65Systems65and65the65Neuromuscular65Juncti
on
Chapter6519:65Neurobiology65of65Schizophrenia,65Mood65Disorders,65and65Anxiety65Disorders
Chapter6520:65Alterations65of65Neurologic65Function65in65Children
Chapter6521:65Mechanisms65of65Hormonal65Regulation
Chapter6522:65Alterations65of65Hormonal65Regulation
Chapter6523:65Obesity65and65Disorders65of65Nutrition
Chapter6524:65Structure65and65Function65of65the65Reproductive65Systems
Chapter6525:65Alterations65of65the65Female65Reproductive65System
Chapter6526:65Alterations65of65the65Male65Reproductive65System
Chapter6527:65Sexually65Transmitted65Infections
Chapter6528:65Structure65and65Function65of65the65Hematologic65System
Chapter6529:65Alterations65of65Erythrocytes,65Platelets,65and65Hemostatic65Function
Chapter6530:65Alterations65of65Leukocyte65and65Lymphoid65Function
Chapter6531:65Alterations65of65Hematologic65Function65in65Children
Chapter6532:65Structure65and65Function65of65the65Cardiovascular65and65Lymphatic65Systems
Chapter6533:65Alterations65of65Cardiovascular65Function
Chapter6534:65Alterations65of65Cardiovascular65Function65in65Children
Chapter6535:65Structure65and65Function65of65the65Pulmonary65System
Chapter6536:65Alterations65of65Pulmonary65Function
Chapter6537:65Alterations65of65Pulmonary65Function65in65Children
Chapter6538:65Structure65and65Function65of65the65Renal65and65Urologic65Systems
Chapter6539:65Alterations65of65Renal65and65Urinary65Tract65Function
Chapter6540:65Alterations65of65Renal65and65Urinary65Tract65Function65in65Children
Chapter6541:65Structure65and65Function65of65the65Digestive65System
Chapter6542:65Alterations65of65Digestive65Function
Chapter6543:65Alterations65of65Digestive65Function65in65Children
Chapter6544:65Structure65and65Function65of65the65Musculoskeletal65System
Chapter6545:65Alterations65of65Musculoskeletal65 Function
Chapter6546:65Alterations65of65Musculoskeletal65Function65in65Children
Chapter6547:65Structure,65Function,65and65Disorders65of65the65Integument
Chapter6548:65Alterations65of65the65Integument65in65Children
Chapter6549:65Shock,65Multiple65Organ65Dysfunction65Syndrome,65and65Burns65in65Adults
Chapter6550:65Shock,65Multiple65Organ65Dysfunction65Syndrome,65and65Burns65in65Children
, (8th6 5 Children
McCance:6 5 Pathophysiology:6 5 The6 5 Biologic6 5 Basis6 5 for6 5 Disease6 5 in6 5 Adults6 5 and
Edition)6 5 TEST6
5B
Part651:65CENTRAL65CONCEPTS65OF65PATHOPHYSIOLOGY:65CELLS65AND65TISS
UES65Unit65I:65THE65CELL
CHAPTER6501:65CELLULAR65BIOLOGY
MULTIPLE65CHOICE
1. Which65statement65best65describes65the65cellular65function65of65metabolic65absorption?
a. Cells65can65produce65proteins.
b. Cells65can65secrete65digestive65enzy
mes.
c. Cells65can65take65in65and65use65nutri
ents.
d. Cells65can65synthesize65fats.
ANS:65 C
In65metabolic65absorption,65all65cells65take65in65and65use65nutrients65and65other65substances65fro
m65their65surroundings.65The65remaining65options65are65not65inclusive65in65their65descriptions65of
65cellular65metabolic65absorption.
PTS:6 5 6 5 1 DIF: Cognitive65Level:65Remembering
2. Where6 5 is6 5 most6 5 of6 5 a6 5 cell’s6 5 genetic6 5 information,6 5 including6 5 RNA6 5 and6 5 DNA,6 5 contained
?
a. Mitochondria
b. Ribosome
c. Nucleolus
d. Lysosome
ANS:6 5 C
The6 5 nucleus6 5 contains6 5 the6 5 nucleolus,6 5 a6 5 small6 5 dense6 5 structure6 5 composed6 5 largely6
5 of6 5 RNA,6 5 mos65t6 5 of6 5 the6 5 cellular6 5 DNA,6 5 and6 5 the6 5 DNA-
binding6 5 proteins,6 5 such6 5 as6 5 the6 5 histones,6 5 which6 5 regulate6 5 its6 5 activity.6 5 The6 5 mitoc
hondria6 5 are6 5 res65ponsible6 5 for6 5 cellular6 5 respiration6 5 and6 5 energy6 5 production.
Ribosomes’65chief65function6 5 is6 5 to65provide6 5 sites6 5 for65cellular65protein6 5 synthesis.6 5 Lysos
omes6 5 functi65on6 5 as6 5 the6 5 intracellular6 5 digestive6 5 system.
PTS: 1 DIF: Cognitive6 5 Level:6 5 Remembering
3. Which6 5 component6 5 of6 5 the6 5 cell6 5 produces6 5 hydrogen6 5 peroxide6 5 (H2O2)6 5 by65using6
5 oxygen6 5 to6 5 re65move6 5 hydrogen6 5 atoms6 5 from6 5 specific6 5 substrates6 5 in6 5 an6 5 oxida
tive6 5 reaction?
a. Lysosomes
b. Peroxisomes
c. Ribosomes
d. Endosome
ANS:6 5 B
, (8th6 5 Children
McCance:6 5 Pathophysiology:6 5 The6 5 Biologic6 5 Basis6 5 for6 5 Disease6 5 in6 5 Adults6 5 and
Edition)6 5 TEST6
5B
Peroxisomes6 5 are6 5 so6 5 named6 5 because6 5 they6 5 usually6 5 contain6 5 enzymes6 5 that6 5 use6 5 o
xygen6 5 to6 5 remo65ve6 5 hydrogen6 5 atoms6 5 from6 5 specific6 5 substrates6 5 in6 5 an6 5 oxidative6 5 r
eaction6 5 that6 5 produces6 5 H2O2,6 5 wh65ich6 5 is6 5 a6 5 powerful6 5 oxidant6 5 and6 5 potentially6 5 de
structive6 5 if6 5 it6 5 accumulates6 5 or6 5 escapes6 5 from6 5 pero65xisomes.
Ribosomes6 5 are6 5 RNA-
protein6 5 complexes6 5 (nucleoproteins)6 5 that6 5 are6 5 synthesized6 5 in6 5 the6 5 nucleolus6 5 and6 5 s
ecreted6 5 into6 5 t65he6 5 cytoplasm6 5 through6 5 pores6 5 in6 5 the6 5 nuclear6 5 envelope6 5 called6 5 nu
clear6 5 pore6 5 complexes.6 5 Lysoso65mes6 5 are6 5 saclike6 5 structures6 5 that6 5 originate6 5 from6 5 t
he6 5 Golgi6 5 complex6 5 and6 5 contain6 5 more6 5 than6 5 4065digestive6 5 enzymes6 5 called6 5 hydrol
ases,6 5 which6 5 catalyze6 5 bonds6 5 in6 5 proteins,6 5 lipids,6 5 nucleic6 5 acids
,6 5 and6 5 carbohydrates.6 5 An6 5 endosome6 5 is6 5 a6 5 vesical6 5 that6 5 has6 5 been6 5 pinched6 5 off6
5 from6 5 the6 5 cellular65membrane.
PTS: 1 DIF: Cognitive6 5 Level:6 5 Remembering
4. Which6 5 cell6 5 component6 5 is6 5 capable6 5 of6 5 cellular6 5 autodigestion6 5 when6 5 it6 5 is6 5 released6 5 durin
g6 5 cell6 5 injury?
a. Ribosome
b. Golgi6 5 complex
c. Smooth65 endoplasmic65 reticu
lu65m
d. Lysosomes
ANS:6 5 D
The6 5 lysosomal6 5 membrane6 5 acts6 5 as6 5 a6 5 protective6 5 shield6 5 between6 5 the6 5 powerful6 5 d
igestive6 5 enzym65es65within65the65lysosome65and65the65cytoplasm,65preventing65their65leakage6
5into65the65cytoplasmic65m6 5 atrix.6 5 Disruption6 5 of6 5 the6 5 membrane6 5 by6 5 various6 5 treatme
nts6 5 or6 5 cellular6 5 injury6 5 leads6 5 to6 5 a6 5 releas65e65of65the65lysosomal65enzymes,65which65ca
n65then65react65with65their65specific65substrates,65causing65ce6 5 llular6 5 self-
digestion.6 5 The6 5 chief6 5 function6 5 of6 5 a6 5 ribosome6 5 is6 5 to6 5 provide6 5 sites6 5 for6 5 cellular6 5 protein6
5 synthesis
.6 5 The6 5 Golgi6 5 complex6 5 is6 5 a6 5 network6 5 of6 5 flattened,6 5 smooth6 5 vesicles6 5 and6 5 membra
nes6 5 often6 5 locate65d6 5 near6 5 the6 5 cell6 5 nucleus.6 5 The6 5 smooth6 5 endoplasmic6 5 reticulum6
5 is6 5 involved6 5 in6 5 steroid6 5 hormone65production6 5 and6 5 removing6 5 toxic6 5 substances6 5 fro
m6 5 the6 5 cell.
PTS: 1 DIF: Cognitive6 5 Level:6 5 Remembering
5. Which6 5 cAMP-mediated6 5 response6 5 is6 5 related6 5 to6 5 antidiuretic6 5 hormone?
a. Increased6 5 heart6 5 rate6 5 and6 5 force65of6 5 c
ontracti65on
b. Secretion6 5 of6 5 cortisol
c. Increased6 5 retention6 5 of6 5 water
d. Breakdown6 5 of6 5 fat
ANS:6 5 C
Antidiuretic6 5 hormone6 5 leads6 5 to6 5 increased6 5 retention6 5 of6 5 water6 5 in6 5 the6 5 body.6 5 Epin
ephrine6 5 causes65increases6 5 in6 5 heart6 5 rate6 5 and6 5 force6 5 of6 5 contraction.6 5 Increased6 5 cor
tisol6 5 secretion6 5 is6 5 due6 5 to6 5 ACT
H.6 5 Breakdown6 5 of6 5 fat6 5 is6 5 due6 5 to6 5 glucagon.
PTS: 1 DIF: Cognitive6 5 Level:6 5 Remembering
6. During6 5 which6 5 phase6 5 of6 5 the6 5 cell6 5 cycle6 5 is6 5 DNA6 5 synthesized?
