NR 507 MIDTERM QUIZ QUESTIONS
WITH COMPLETE ANSWERS
Damage occurs with ABO incompatibility because - Answer-Complement damages
RBC membrane causing RBC lysis
Which of the following assessment findings would be expected in a patient who
presents with urticaria? - Answer-Eosinophilia
Example of Type 4 hypersensitivity reaction - Answer-Contact dermatitis (poison ivy,
metal allergy)
Type 3 hypersensitivity reactions - Answer-- Are NOT organ specific
- antigen-antibody complex deposited in tissues
Type 3 hypersensitivity reaction examples - Answer-Rheumatoid Arthritis
Systemic Lupus Erythematous (SLE)
Scope of Damage of SLE - Answer-- Facial rash confined to the cheeks (malar rash)
- Discoid rash (raised patches, scaling)
- photosensitivity (development of skin rash as a results of sunlight exposure)
- oral or nasopharyngeal ulcers
- hematologic disorders (hemolytic anemia, leukopenia, lymphopenia, or
thrombocytopenia)
- immunologic disorders (antibodies against double-stranded DNA or Smith antigen,
false positive serologic tests for syphilis, or antiphospholipid antibodies)
- Non-erosive arthritis of at least 2 peripheral joints
- Serositis (pleurisy, pericarditis)
- renal disorder (persistent proteinuria of > 0.5 g/day or > 3 g/day on dipstick of cellular
casts)
- neurological disorders (seizures, psychosis)
- presence of antinuclear antibody (ANA)
Autoimmune diseases can be - Answer-Familial although not all develop the same
disease, but several members may have different disorders characterized by a variety
of hypersensitivity reactions
Associations with particular autoimmune diseases have been identified for a variety of -
Answer-Major histocompatibility complex (MHC) alleles or non-MHC genes
Alloimmunity - Answer-General term used to describe when an individuals immune
system reactions against antigens on the tissues of other members of the same species
, Examples of alloimmunity - Answer-- Neonatal disease where the maternal immune
system becomes sensitized against antigens expressed by the fetus
- transplant rejection
- transfusion reaction
A rash in Type 1 hypersensitivity reaction - Answer-Immediate reaction, termed atopic
dermatitis, usually characterized by widely distributed lesions
A rash in Type 4 hypersensitivity reaction - Answer-Contact dermatitis (delayed
hypersensitivity) consists of lesions only at the site of contact with the allergen
Best choice of treatment for Type 4 rash - Answer-Topical corticosteroids
An example of primary immunodeficiency is: - Answer-Chronic granulomatous disease
Is a predominant cause of secondary immune deficiencies worldwide - Answer-
Malnutrition
Which of the following is an autoimmune disease? - Answer-Systemic lupus
erythematosus (SLE)
Primary immunodeficiencies - Answer-Are the result of a single gene defect
Example of primary immunodeficiency - Answer-- chronic granulomatous disease of
childhood
- DiGeorge syndrome
- Familial Mediterranean fever
- job syndrome
- common variable immunodeficiency
Example of secondary immunodeficiency - Answer-- Human Immunodeficiency Virus
- pneumocystis carinii
- pneumonia
- sinus infection
- lung cancer
Pneumocystis Carinii is an example of - Answer-A secondary immune disease
Best describes a primary immunodeficiency - Answer-Are less common and occur due
to a defect on the development of the immune system
Most severe form of primary immunodeficiency - Answer-B-lymphocyte deficiency
The major immune system change associated with Sjögren's syndrome is: - Answer-
Autoantibodies and auto-reactive T-cells against apoptotic cells
WITH COMPLETE ANSWERS
Damage occurs with ABO incompatibility because - Answer-Complement damages
RBC membrane causing RBC lysis
Which of the following assessment findings would be expected in a patient who
presents with urticaria? - Answer-Eosinophilia
Example of Type 4 hypersensitivity reaction - Answer-Contact dermatitis (poison ivy,
metal allergy)
Type 3 hypersensitivity reactions - Answer-- Are NOT organ specific
- antigen-antibody complex deposited in tissues
Type 3 hypersensitivity reaction examples - Answer-Rheumatoid Arthritis
Systemic Lupus Erythematous (SLE)
Scope of Damage of SLE - Answer-- Facial rash confined to the cheeks (malar rash)
- Discoid rash (raised patches, scaling)
- photosensitivity (development of skin rash as a results of sunlight exposure)
- oral or nasopharyngeal ulcers
- hematologic disorders (hemolytic anemia, leukopenia, lymphopenia, or
thrombocytopenia)
- immunologic disorders (antibodies against double-stranded DNA or Smith antigen,
false positive serologic tests for syphilis, or antiphospholipid antibodies)
- Non-erosive arthritis of at least 2 peripheral joints
- Serositis (pleurisy, pericarditis)
- renal disorder (persistent proteinuria of > 0.5 g/day or > 3 g/day on dipstick of cellular
casts)
- neurological disorders (seizures, psychosis)
- presence of antinuclear antibody (ANA)
Autoimmune diseases can be - Answer-Familial although not all develop the same
disease, but several members may have different disorders characterized by a variety
of hypersensitivity reactions
Associations with particular autoimmune diseases have been identified for a variety of -
Answer-Major histocompatibility complex (MHC) alleles or non-MHC genes
Alloimmunity - Answer-General term used to describe when an individuals immune
system reactions against antigens on the tissues of other members of the same species
, Examples of alloimmunity - Answer-- Neonatal disease where the maternal immune
system becomes sensitized against antigens expressed by the fetus
- transplant rejection
- transfusion reaction
A rash in Type 1 hypersensitivity reaction - Answer-Immediate reaction, termed atopic
dermatitis, usually characterized by widely distributed lesions
A rash in Type 4 hypersensitivity reaction - Answer-Contact dermatitis (delayed
hypersensitivity) consists of lesions only at the site of contact with the allergen
Best choice of treatment for Type 4 rash - Answer-Topical corticosteroids
An example of primary immunodeficiency is: - Answer-Chronic granulomatous disease
Is a predominant cause of secondary immune deficiencies worldwide - Answer-
Malnutrition
Which of the following is an autoimmune disease? - Answer-Systemic lupus
erythematosus (SLE)
Primary immunodeficiencies - Answer-Are the result of a single gene defect
Example of primary immunodeficiency - Answer-- chronic granulomatous disease of
childhood
- DiGeorge syndrome
- Familial Mediterranean fever
- job syndrome
- common variable immunodeficiency
Example of secondary immunodeficiency - Answer-- Human Immunodeficiency Virus
- pneumocystis carinii
- pneumonia
- sinus infection
- lung cancer
Pneumocystis Carinii is an example of - Answer-A secondary immune disease
Best describes a primary immunodeficiency - Answer-Are less common and occur due
to a defect on the development of the immune system
Most severe form of primary immunodeficiency - Answer-B-lymphocyte deficiency
The major immune system change associated with Sjögren's syndrome is: - Answer-
Autoantibodies and auto-reactive T-cells against apoptotic cells
