WGU D027 Practice Questions 2024/2025
Exam Questions and Detailed Answers |
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A patient has endured several dosage adjustments of his tricyclic
antidepressant, so the provider recommends genetic testing. Which
statement correctly describes the rationale for genetic testing?
a. The CYP2D6 gene influences metabolism of tricyclic antidepressants
and certain other drugs
b. The HER2 gene is a tumor marker that impacts metabolism of tricyclic
antidepressants
c. The BRCA2 gene influences metabolism of certain drugs and increases
the risk for breast cancer
d. The x-linked OPN1MW gene for male color blindness also slows
metabolism of certain drugs - 🧠ANSWER ✔✔a. The CYP2D6 gene
influences metabolism of tricyclic antidepressants and certain other drugs
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,Answer/Rationale: CYP2D6 - page 155 Box 4.3 of Chapter 4 Genes and
Genetic Diseases, McCance & Huether, Unit 2, Genes, Environmental
Lifestyle, and Common Diseases. HER2 is a gene often implicated with
cancer, as is BRCA2. OPN1MW is the gene that codes for color blindness
in men. Metabolism of 25% of all prescribed drugs, including tricyclic
antidepressants, beta adrenergic receptor blockers, and neuroleptics, is
influenced by variants in a certain gene, requiring genetic testing to reduce
trial-and-error in estimating appropriate drug-dosage levels.
As an advanced practice nurse, you want to learn more about the CDC's
initiatives relative to asthma care and management in order to advocate for
asthma sufferers at the state legislative level. Your goal is to reduce
medications costs to patients. Which CDC recommendation supports your
goal?
a. The CDC recommends that payers and employers promote healthy
workspaces to decrease environmental trigger exposures
b. The CDC recommends that providers prescribe the most cost-efficient
long-acting inhalers to lower patient co-pays
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,c. The CDC recommends that providers deviate from the stepwise
approach to lessen the financial impact to the patient
d. The CDC recommends that co-pays be removed for inhaled
corticosteroids and other prescribed medications - 🧠ANSWER ✔✔d. The
CDC recommends that co-pays be removed for inhaled corticosteroids and
other prescribed medications
Answer/Rationale: D - The CDC recommends that co-pays be removed for
inhaled corticosteroids and other prescribed medications per the following
link, https://healthpayerintelligence.com/news/top-10-most-expensive-
chronic-diseases-for-healthcare-payers; Genes, Environmental Lifestyle,
and Common Diseases; Unit 2
A female patient has been recently diagnosed with invasive ductal
carcinoma. As an advanced practice nurse, you understand that she will be
undergoing a multi-faceted treatment approach that will include one or
more medications. Which medication is considered the "gold standard"
endocrine treatment for breast cancer?
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STATEMENT. ALL RIGHTS RESERVED
, a. Fulvestrant (Faslodex), an antiestrogen indicated for metastatic estrogen
receptor-positive breast cancer in post-menopausal women
b. Tamoxifen (Nolvadex), a prodrug that must be converted to active
metabolites in order to block estrogen receptors in breast tissue
c. Trastuzumab (Herceptin), a monoclonal antibody approved for HER2-
positive metastatic breast cancer
d. Lapatinib (Tykerb), an oral inhibitor of HER2 tyrosine kinase and EGFR
tyrosine kinase, resulting in apoptosis and suppression of tumor cell growth
- 🧠ANSWER ✔✔b. Tamoxifen (Nolvadex), a prodrug that must be
converted to active metabolites in order to block estrogen receptors in
breast tissue
Answer/Rationale: Tamoxifen, page 929, Chapter 82 of Lehne, Unit 2,
Human Structures for Self Defense
A patient reports a maternal family history of Lynch syndrome. Which
laboratory finding might indicate a need for further testing for the presence
of Lynch syndrome in this patient?
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STATEMENT. ALL RIGHTS RESERVED
Exam Questions and Detailed Answers |
Get it 100% Correct Answers
A patient has endured several dosage adjustments of his tricyclic
antidepressant, so the provider recommends genetic testing. Which
statement correctly describes the rationale for genetic testing?
a. The CYP2D6 gene influences metabolism of tricyclic antidepressants
and certain other drugs
b. The HER2 gene is a tumor marker that impacts metabolism of tricyclic
antidepressants
c. The BRCA2 gene influences metabolism of certain drugs and increases
the risk for breast cancer
d. The x-linked OPN1MW gene for male color blindness also slows
metabolism of certain drugs - 🧠ANSWER ✔✔a. The CYP2D6 gene
influences metabolism of tricyclic antidepressants and certain other drugs
COPYRIGHT©NINJANERD 2025/2026. YEAR PUBLISHED 2025. COMPANY REGISTRATION NUMBER: 619652435. TERMS OF USE. PRIVACY 1
STATEMENT. ALL RIGHTS RESERVED
,Answer/Rationale: CYP2D6 - page 155 Box 4.3 of Chapter 4 Genes and
Genetic Diseases, McCance & Huether, Unit 2, Genes, Environmental
Lifestyle, and Common Diseases. HER2 is a gene often implicated with
cancer, as is BRCA2. OPN1MW is the gene that codes for color blindness
in men. Metabolism of 25% of all prescribed drugs, including tricyclic
antidepressants, beta adrenergic receptor blockers, and neuroleptics, is
influenced by variants in a certain gene, requiring genetic testing to reduce
trial-and-error in estimating appropriate drug-dosage levels.
As an advanced practice nurse, you want to learn more about the CDC's
initiatives relative to asthma care and management in order to advocate for
asthma sufferers at the state legislative level. Your goal is to reduce
medications costs to patients. Which CDC recommendation supports your
goal?
a. The CDC recommends that payers and employers promote healthy
workspaces to decrease environmental trigger exposures
b. The CDC recommends that providers prescribe the most cost-efficient
long-acting inhalers to lower patient co-pays
COPYRIGHT©NINJANERD 2025/2026. YEAR PUBLISHED 2025. COMPANY REGISTRATION NUMBER: 619652435. TERMS OF USE. PRIVACY 2
STATEMENT. ALL RIGHTS RESERVED
,c. The CDC recommends that providers deviate from the stepwise
approach to lessen the financial impact to the patient
d. The CDC recommends that co-pays be removed for inhaled
corticosteroids and other prescribed medications - 🧠ANSWER ✔✔d. The
CDC recommends that co-pays be removed for inhaled corticosteroids and
other prescribed medications
Answer/Rationale: D - The CDC recommends that co-pays be removed for
inhaled corticosteroids and other prescribed medications per the following
link, https://healthpayerintelligence.com/news/top-10-most-expensive-
chronic-diseases-for-healthcare-payers; Genes, Environmental Lifestyle,
and Common Diseases; Unit 2
A female patient has been recently diagnosed with invasive ductal
carcinoma. As an advanced practice nurse, you understand that she will be
undergoing a multi-faceted treatment approach that will include one or
more medications. Which medication is considered the "gold standard"
endocrine treatment for breast cancer?
COPYRIGHT©NINJANERD 2025/2026. YEAR PUBLISHED 2025. COMPANY REGISTRATION NUMBER: 619652435. TERMS OF USE. PRIVACY 3
STATEMENT. ALL RIGHTS RESERVED
, a. Fulvestrant (Faslodex), an antiestrogen indicated for metastatic estrogen
receptor-positive breast cancer in post-menopausal women
b. Tamoxifen (Nolvadex), a prodrug that must be converted to active
metabolites in order to block estrogen receptors in breast tissue
c. Trastuzumab (Herceptin), a monoclonal antibody approved for HER2-
positive metastatic breast cancer
d. Lapatinib (Tykerb), an oral inhibitor of HER2 tyrosine kinase and EGFR
tyrosine kinase, resulting in apoptosis and suppression of tumor cell growth
- 🧠ANSWER ✔✔b. Tamoxifen (Nolvadex), a prodrug that must be
converted to active metabolites in order to block estrogen receptors in
breast tissue
Answer/Rationale: Tamoxifen, page 929, Chapter 82 of Lehne, Unit 2,
Human Structures for Self Defense
A patient reports a maternal family history of Lynch syndrome. Which
laboratory finding might indicate a need for further testing for the presence
of Lynch syndrome in this patient?
COPYRIGHT©NINJANERD 2025/2026. YEAR PUBLISHED 2025. COMPANY REGISTRATION NUMBER: 619652435. TERMS OF USE. PRIVACY 4
STATEMENT. ALL RIGHTS RESERVED
