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Quiz: Pharmacodynamics
Ans: How the drug effects the body
-therapeutic vs. side effects
• Is it stimulating?
• Is it depressing?
• Does it block something?
-Onset of action
• Route, Dosage
-Duration of action
• Redistribution rate, metabolism rate and excretion rate
-Mechanism of action
• Drugs simply speed up or slow down what is already occurring in the body
-Efficacy
• (Intrinsic activity) After binding, the drugs capacity to cause an effect
-Potency
• The amount of a drug needed to produce a given effect
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, Quiz: efficacy examples
Ans: -Agonist (Efficacy = 100)
-Partial Agonist (Efficacy = > 0 < 100)
-Antagonist (Efficacy = 0.0)
-Inverse Agonist (Efficacy = < 0)
Quiz: Agonist:
Ans: Compounds which give maximal response after receptor occupation and
activation.
-Example: Oxycodone
Quiz: Partial Agonists:
Ans: Compounds which activate the receptor but not at the maximal
response.
-Example Buprenorphine (Suboxone) or Buspirone
Quiz: Antagonist:
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, Ans: Blocks the action of an agonist.
-Example: Neuroleptics, Naloxone
Quiz: Inverse Agonist:
Ans: Binds to receptor and has the opposite action of an agonist and below
baselinesignal transduction
Quiz: Pharmacokinetics
Ans: How the body effects the drug
-Absorption, distribution, metabolism and elimination (ADME)
-Metabolizing the drug via CYP450 through the gut & liver
Quiz: Bioavailability
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, Ans: Absorption: Drugs cross a barrier.
-Involves bioavailability or Quantity of drug reaching circulation/quantityof the
drug administered.
• Our own barriers such as skin and mucous membranes as well as food,
molecular weight, chemical, biological barriers, etc. reduce how much drug is
actually absorbed and available. IV route has 100% bioavailability. All other
routes <100%
Quiz: First pass metabolism
Ans: -reduces the concentration of a drug
• travels through digestive system & entering the liver.
• reducing the bioavailability of the drug
Quiz: rate is reduced by:
Ans: -Route (IV, PO, Rectum, etc.)
-Dosage (Concentration)
-Lipid Solubility
Quiz: Drugs that cross the BBB are _____________
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