Optical Coherence Tomography (OCT)
exam with correct answers
Current Medical Imaging Modalities include - correct answer ✔- X-ray and
||! ||! ||! ||! ||! ||! ||! ||! ||! ||! ||!
CT ||!
-Nuclear Medicine Imaging (PET and SPECT)
||! ||! ||! ||! ||!
-MRI imaging ||! ||!
-Ultrasonic imaging ||!
How does MRI imaging work? - correct answer ✔Uses magnetic resonance
||! ||! ||! ||! ||! ||! ||! ||! ||! ||! ||!
to image soundwaves
||! ||!
Do we need another imaging technology such as OCT? - correct answer
||! ||! ||! ||! ||! ||! ||! ||! ||! ||! ||! ||!
✔YES! OCT has very high spacial resolution compared to other imaging
||! ||! ||! ||! ||! ||! ||! ||! ||! ||! ||!
technologies. It also has good contrast and the optic wavelengths give you
||! ||! ||! ||! ||! ||! ||! ||! ||! ||! ||!
molecular interactions.
||! ||!
What light does OCT usually use? - correct answer ✔Infrared light because
||! ||! ||! ||! ||! ||! ||! ||! ||! ||! ||!
their energy is low and allows repeat measurements without worrying
||! ||! ||! ||! ||! ||! ||! ||! ||! ||! ||!
about ionization damage.
||! ||!
Advantages of OCT - correct answer ✔- non-invasive
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-high contrast ||!
-high spatial resolution
||! ||!
, - Unlike other optical imaging that only give the surface image of the
||! ||! ||! ||! ||! ||! ||! ||! ||! ||! ||! ||! ||!
tissue, OCT looks at the cross-section
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Optical imaging (Surface imaging) - correct answer ✔-Microscope
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- Fluorescence Imaging
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- Confocal microscopy
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- Two/multi photon fluorescence microscopy
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- Time domain optical imaging
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-Polarization imaging ||!
What is the challenge for OCT of biological tissues? - correct answer ✔-
||! ||! ||! ||! ||! ||! ||! ||! ||! ||! ||! ||!
water,hemoglobin, and melanin all have an absorption spectrum ||! ||! ||! ||! ||! ||! ||!
-Most imaging only gives the surface image of the tissue, and we want the
||! ||! ||! ||! ||! ||! ||! ||! ||! ||! ||! ||! ||!
cross section
||! ||!
-Clinical practices want a cross-sectional image, where you can get an
||! ||! ||! ||! ||! ||! ||! ||! ||! ||!
"optical biopsy" to prevent an invasive biopsy.
||! ||! ||! ||! ||! ||! ||!
-In biological tissue, · when light is shined scattering occurs everywhere
||! ||! ||! ||! ||! ||! ||! ||! ||! ||! ||!
and destroys localization
||! ||!
Light travels to multiple spots and on average changes direction every
||! ||! ||! ||! ||! ||! ||! ||! ||! ||! ||!
___________ microns. - correct answer ✔50 ||! ||! ||! ||! ||!
Coherence gating - correct answer ✔- photons that · do not scatter travel
||! ||! ||! ||! ||! ||! ||! ||! ||! ||! ||! ||! ||!
a minimal distance and bounce back immediately compared to those that
||! ||! ||! ||! ||! ||! ||! ||! ||! ||! ||!
do scatter ||!
- Can put a filter to collect information from photons with a short path
||! ||! ||! ||! ||! ||! ||! ||! ||! ||! ||! ||! ||! ||!
length
exam with correct answers
Current Medical Imaging Modalities include - correct answer ✔- X-ray and
||! ||! ||! ||! ||! ||! ||! ||! ||! ||! ||!
CT ||!
-Nuclear Medicine Imaging (PET and SPECT)
||! ||! ||! ||! ||!
-MRI imaging ||! ||!
-Ultrasonic imaging ||!
How does MRI imaging work? - correct answer ✔Uses magnetic resonance
||! ||! ||! ||! ||! ||! ||! ||! ||! ||! ||!
to image soundwaves
||! ||!
Do we need another imaging technology such as OCT? - correct answer
||! ||! ||! ||! ||! ||! ||! ||! ||! ||! ||! ||!
✔YES! OCT has very high spacial resolution compared to other imaging
||! ||! ||! ||! ||! ||! ||! ||! ||! ||! ||!
technologies. It also has good contrast and the optic wavelengths give you
||! ||! ||! ||! ||! ||! ||! ||! ||! ||! ||!
molecular interactions.
||! ||!
What light does OCT usually use? - correct answer ✔Infrared light because
||! ||! ||! ||! ||! ||! ||! ||! ||! ||! ||!
their energy is low and allows repeat measurements without worrying
||! ||! ||! ||! ||! ||! ||! ||! ||! ||! ||!
about ionization damage.
||! ||!
Advantages of OCT - correct answer ✔- non-invasive
||! ||! ||! ||! ||! ||! ||!
-high contrast ||!
-high spatial resolution
||! ||!
, - Unlike other optical imaging that only give the surface image of the
||! ||! ||! ||! ||! ||! ||! ||! ||! ||! ||! ||! ||!
tissue, OCT looks at the cross-section
||! ||! ||! ||! ||!
Optical imaging (Surface imaging) - correct answer ✔-Microscope
||! ||! ||! ||! ||! ||! ||!
- Fluorescence Imaging
||! ||!
- Confocal microscopy
||! ||!
- Two/multi photon fluorescence microscopy
||! ||! ||! ||!
- Time domain optical imaging
||! ||! ||! ||!
-Polarization imaging ||!
What is the challenge for OCT of biological tissues? - correct answer ✔-
||! ||! ||! ||! ||! ||! ||! ||! ||! ||! ||! ||!
water,hemoglobin, and melanin all have an absorption spectrum ||! ||! ||! ||! ||! ||! ||!
-Most imaging only gives the surface image of the tissue, and we want the
||! ||! ||! ||! ||! ||! ||! ||! ||! ||! ||! ||! ||!
cross section
||! ||!
-Clinical practices want a cross-sectional image, where you can get an
||! ||! ||! ||! ||! ||! ||! ||! ||! ||!
"optical biopsy" to prevent an invasive biopsy.
||! ||! ||! ||! ||! ||! ||!
-In biological tissue, · when light is shined scattering occurs everywhere
||! ||! ||! ||! ||! ||! ||! ||! ||! ||! ||!
and destroys localization
||! ||!
Light travels to multiple spots and on average changes direction every
||! ||! ||! ||! ||! ||! ||! ||! ||! ||! ||!
___________ microns. - correct answer ✔50 ||! ||! ||! ||! ||!
Coherence gating - correct answer ✔- photons that · do not scatter travel
||! ||! ||! ||! ||! ||! ||! ||! ||! ||! ||! ||! ||!
a minimal distance and bounce back immediately compared to those that
||! ||! ||! ||! ||! ||! ||! ||! ||! ||! ||!
do scatter ||!
- Can put a filter to collect information from photons with a short path
||! ||! ||! ||! ||! ||! ||! ||! ||! ||! ||! ||! ||! ||!
length
