OPT 202 – Pharmacodynamics UPDATED
ACTUAL Questions and CORRECT
Answers
Pharmacodynamics - CORRECT ANSWER - The actions of a drug on a living organism
MOA - CORRECT ANSWER - Mechanism of action
Fundamental principle of Pharmacodynamics - CORRECT ANSWER - Drugs must
interact with a molecular target to have an effect
Target = Receptor
Drug-occupied receptor changes physical and chemical properties, leading to... - CORRECT
ANSWER - Interactions with cellular molecules to cause a biologic response
Practical Consequences: Dose and effect relationships are largely determined by... - CORRECT
ANSWER - Receptors (there are a finite number of receptors in a given cell)
Practical Consequences: Selectivity of drug action is due to... - CORRECT ANSWER -
Receptors
Practical Consequences: Action of agonists and antagonists is mediated by... - CORRECT
ANSWER - Receptors
Practical Consequences: When a drug binds to a receptor, one of the following actions usually
occur... (4 things) - CORRECT ANSWER - 1. An ion channel is opened or closed
2. Biochemical messengers (second messengers) are activated
3. A normal cellular function is inhibited
, 4. A cellular function is "turned on"
Law of Mass Action - CORRECT ANSWER - The combination of drug (ligand) and
receptor depends on the concentrations of each
The amount of drug-receptor complex formed determines the magnitude of the response
A minimum number of drug-receptor complexes must be formed for a response to be intiated
As drug concentration increases, the number of drug-receptor complexes increases and drug
effect increases
A point will be reached at which all receptors are bound to a drug
Ligand - CORRECT ANSWER - Any molecule that binds to a receptor
Drug Receptor Occupancy Curves - CORRECT ANSWER - Drug-Receptor complex
formation is proportional to the concentrations of drug and receptor - BUT the relationship is not
linear
Use Semilogarithic graph
Factors Affecting Drug-Target Interactions - CORRECT ANSWER - Drug response is
regulated by two properties - Affinity & Efficacy
Affinity - CORRECT ANSWER - The ability of the drug to bind to its receptor (How
much do the drug like the receptor)
Efficacy - CORRECT ANSWER - The ability of the drug to alter the activity of its
receptor (How well does the drug work)
ACTUAL Questions and CORRECT
Answers
Pharmacodynamics - CORRECT ANSWER - The actions of a drug on a living organism
MOA - CORRECT ANSWER - Mechanism of action
Fundamental principle of Pharmacodynamics - CORRECT ANSWER - Drugs must
interact with a molecular target to have an effect
Target = Receptor
Drug-occupied receptor changes physical and chemical properties, leading to... - CORRECT
ANSWER - Interactions with cellular molecules to cause a biologic response
Practical Consequences: Dose and effect relationships are largely determined by... - CORRECT
ANSWER - Receptors (there are a finite number of receptors in a given cell)
Practical Consequences: Selectivity of drug action is due to... - CORRECT ANSWER -
Receptors
Practical Consequences: Action of agonists and antagonists is mediated by... - CORRECT
ANSWER - Receptors
Practical Consequences: When a drug binds to a receptor, one of the following actions usually
occur... (4 things) - CORRECT ANSWER - 1. An ion channel is opened or closed
2. Biochemical messengers (second messengers) are activated
3. A normal cellular function is inhibited
, 4. A cellular function is "turned on"
Law of Mass Action - CORRECT ANSWER - The combination of drug (ligand) and
receptor depends on the concentrations of each
The amount of drug-receptor complex formed determines the magnitude of the response
A minimum number of drug-receptor complexes must be formed for a response to be intiated
As drug concentration increases, the number of drug-receptor complexes increases and drug
effect increases
A point will be reached at which all receptors are bound to a drug
Ligand - CORRECT ANSWER - Any molecule that binds to a receptor
Drug Receptor Occupancy Curves - CORRECT ANSWER - Drug-Receptor complex
formation is proportional to the concentrations of drug and receptor - BUT the relationship is not
linear
Use Semilogarithic graph
Factors Affecting Drug-Target Interactions - CORRECT ANSWER - Drug response is
regulated by two properties - Affinity & Efficacy
Affinity - CORRECT ANSWER - The ability of the drug to bind to its receptor (How
much do the drug like the receptor)
Efficacy - CORRECT ANSWER - The ability of the drug to alter the activity of its
receptor (How well does the drug work)
