4. The isotype found predominantly in mucosal secretions
ANS: A. IgA accounts for almost two thirds of the 3 g of antibody produced each day by
Cellular and Molecular Immunology 9th an adult, most of which is produced in the gastrointestinal associated lymphoid tissues and
secreted into the gut lumen.
Edition Abbas Test Bank Latest Updates 5. The isotype most closely associated with immediate hypersensitivity (allergic) disease
2023 A+ GRADE. ANS: C. Most IgE that is secreted is bound to mast cells, and it plays a role in the activation
of mast cells during allergic reactions.
Questions 6-10
Match each description in questions 6-10 with the appropriate lettered term (A-I).
A. Conformational determinant
Abbas: Cellular and Molecular Immunology, 9th Edition
Antibodies and Antigens Test Bank 2
Test Bank
B. Linear determinant
C. Neoantigenic determinant
Matching
D. Hinge region
E. Immun complex
Questions 1-5
F. Fab
Match each of the descriptions in questions 1-5 with the correct lettered antibody isotype
(A-E). (Answers may be used more than once.) G. Fc
A. IgA H. Tail piece
B. IgD I. Hapten
C. IgE
D. IgG 6. A proteolytic fragment of an antibody molecule that contains an intact antigen- binding
site
E. IgM
ANS: F. Fab fragments, derived from enzymatic cleavage of Ig molecules, are composed
1. The secreted form of this isotype forms pentamers around a J chain
of one intact light chain covalently linked to the N-terminal region of one heavy chain and
ANS: E. IgM is secreted as a J chain–linked pentamer. include a single intact antigen-binding site.
2. The most abundant Ig isotype in the blood 7. A three-dimensional shape, formed by a portion of a macromolecule, to which an
antibody binds
ANS: D. The blood IgG concentration is about 3.5mg/ml and includes four subtypes
(IgG1 to IgG4). ANS: A. Conformational determinants will usually be destroyed by physicochemical
disruption of macromolecules, such as by denaturation or proteolysis of proteins.
3. The isotype only found in membrane-bound form on naive B cells
8. A small chemical group recognized by an antibody that is attached to a larger
ANS: B. Very little IgD is secreted, and in membrane form is only on the surface of naive macromolecule
B cells. Its function is not well understood.
ANS: A. IgA accounts for almost two thirds of the 3 g of antibody produced each day by
Cellular and Molecular Immunology 9th an adult, most of which is produced in the gastrointestinal associated lymphoid tissues and
secreted into the gut lumen.
Edition Abbas Test Bank Latest Updates 5. The isotype most closely associated with immediate hypersensitivity (allergic) disease
2023 A+ GRADE. ANS: C. Most IgE that is secreted is bound to mast cells, and it plays a role in the activation
of mast cells during allergic reactions.
Questions 6-10
Match each description in questions 6-10 with the appropriate lettered term (A-I).
A. Conformational determinant
Abbas: Cellular and Molecular Immunology, 9th Edition
Antibodies and Antigens Test Bank 2
Test Bank
B. Linear determinant
C. Neoantigenic determinant
Matching
D. Hinge region
E. Immun complex
Questions 1-5
F. Fab
Match each of the descriptions in questions 1-5 with the correct lettered antibody isotype
(A-E). (Answers may be used more than once.) G. Fc
A. IgA H. Tail piece
B. IgD I. Hapten
C. IgE
D. IgG 6. A proteolytic fragment of an antibody molecule that contains an intact antigen- binding
site
E. IgM
ANS: F. Fab fragments, derived from enzymatic cleavage of Ig molecules, are composed
1. The secreted form of this isotype forms pentamers around a J chain
of one intact light chain covalently linked to the N-terminal region of one heavy chain and
ANS: E. IgM is secreted as a J chain–linked pentamer. include a single intact antigen-binding site.
2. The most abundant Ig isotype in the blood 7. A three-dimensional shape, formed by a portion of a macromolecule, to which an
antibody binds
ANS: D. The blood IgG concentration is about 3.5mg/ml and includes four subtypes
(IgG1 to IgG4). ANS: A. Conformational determinants will usually be destroyed by physicochemical
disruption of macromolecules, such as by denaturation or proteolysis of proteins.
3. The isotype only found in membrane-bound form on naive B cells
8. A small chemical group recognized by an antibody that is attached to a larger
ANS: B. Very little IgD is secreted, and in membrane form is only on the surface of naive macromolecule
B cells. Its function is not well understood.
