WGU D116 Unit 2
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1. A patient receives a drug that has a narrow A. Monitor plasma drug levels
therapeutic range. What is the nurse admin-
istering this medication expected to do? A drug with a narrow therapeutic range
is more difficult to administer safely be-
A. Monitor plasma drug levels. cause the difference between the mini-
mum effective concentration (MEC ) and
B. Administer the drug at intervals longer the toxic concentration is small. Patients
than the drug half-life. taking these medications must have their
plasma drug levels monitored closely to
C. Teach the patient that maximum drug ef-
ensure that they are getting an effective
fects will occur within a short period.
dose that is not toxic.
D. Administer this medication intravenously
2. A patient is receiving intravenous gentam- D. The patient is taking another medica-
icin. A serum drug test reveals toxic levels. tion that binds to serum albumin.
The dosing is correct, and this medication
has been tolerated by this patient in the Correct! Gentamicin binds to albumin,
past. but only weakly. In the presence of an-
other drug that binds to albumin, gen-
What is a probable cause of the test result? tamicin can rise to toxic levels in blood
serum.
A. The drug was not completely dissolved in
the IV solution.
B. A loading dose was not given.
C. The medication is being given at a frequen-
cy that is longer than its half-life.
D. The patient is taking another medication
that binds to serum albumin.
3.
, WGU D116 Unit 2
Study online at https://quizlet.com/_e8ohaj
What are the components of pharmacokinet- Absorption, distribution, metabolism, ex-
ics? cretion
4. Does the volume of distribution increase or DECREASES
decrease as the concentration of a drug in
the blood plasma increases?
5. A patient reports becoming "immune" to a C. Desensitization of receptor sites by
medication because it no longer works to continual exposure to the drug
alleviate symptoms.
The provider recognizes that this decreased Continual exposure to an agonist would
effectiveness is likely caused by what? cause the cell to become less responsive
or desensitized
A. synthesis of more receptor sites in re-
sponse to the medication
B. decreased selectivity of receptor sites, re-
sulting in a variety of effects
C. desensitization of receptor sites by contin-
ual exposure to the drug
D. antagonists produced by the body that
compete with the drug for receptor sites
6. What occurs when a drug binds to a receptor A. It increases or decreases the activity of
in the body? that receptor
A. It increases or decreases the activity of Correct! When a drug binds to a recep-
that receptor. tor, it mimics or blocks the actions of the
usual endogenous regulatory molecules,
B. It alters the receptor to become non- either increasing or decreasing the rate
responsive to its usual endogenous mole-
cules.
, WGU D116 Unit 2
Study online at https://quizlet.com/_e8ohaj
of the physiologic activity normally con-
C. It prevents the action of the receptor by trolled by that receptor.
altering its response to chemical mediators.
D. It gives the receptor a new function.
7. Which pharmacodynamic principle is most A. Therapeutic index
correlated with drug toxicity?
Which is calculated by dividing the me-
A. Therapeutic index dian toxic dose by the median efficacious
dose
B. Intrinsic activity
C. Competitive antagonists
D. Efficacy
8. A patient who is taking morphine for pain C. It is selective to receptors that regulate
asks the nurse how a pain medication can more than one body process
also cause constipation.
What is the nurse's response? Correct! Morphine is a medication that is
selective to receptor types that regulate
A. It binds to different types of receptors in more than one process.
the body.
B. It can cause constipation in toxic doses.
C. It is selective to receptors that regulate
more than one body process.
D. It causes only one type of response, and
the constipation is coincidental.
9.
Study online at https://quizlet.com/_e8ohaj
1. A patient receives a drug that has a narrow A. Monitor plasma drug levels
therapeutic range. What is the nurse admin-
istering this medication expected to do? A drug with a narrow therapeutic range
is more difficult to administer safely be-
A. Monitor plasma drug levels. cause the difference between the mini-
mum effective concentration (MEC ) and
B. Administer the drug at intervals longer the toxic concentration is small. Patients
than the drug half-life. taking these medications must have their
plasma drug levels monitored closely to
C. Teach the patient that maximum drug ef-
ensure that they are getting an effective
fects will occur within a short period.
dose that is not toxic.
D. Administer this medication intravenously
2. A patient is receiving intravenous gentam- D. The patient is taking another medica-
icin. A serum drug test reveals toxic levels. tion that binds to serum albumin.
The dosing is correct, and this medication
has been tolerated by this patient in the Correct! Gentamicin binds to albumin,
past. but only weakly. In the presence of an-
other drug that binds to albumin, gen-
What is a probable cause of the test result? tamicin can rise to toxic levels in blood
serum.
A. The drug was not completely dissolved in
the IV solution.
B. A loading dose was not given.
C. The medication is being given at a frequen-
cy that is longer than its half-life.
D. The patient is taking another medication
that binds to serum albumin.
3.
, WGU D116 Unit 2
Study online at https://quizlet.com/_e8ohaj
What are the components of pharmacokinet- Absorption, distribution, metabolism, ex-
ics? cretion
4. Does the volume of distribution increase or DECREASES
decrease as the concentration of a drug in
the blood plasma increases?
5. A patient reports becoming "immune" to a C. Desensitization of receptor sites by
medication because it no longer works to continual exposure to the drug
alleviate symptoms.
The provider recognizes that this decreased Continual exposure to an agonist would
effectiveness is likely caused by what? cause the cell to become less responsive
or desensitized
A. synthesis of more receptor sites in re-
sponse to the medication
B. decreased selectivity of receptor sites, re-
sulting in a variety of effects
C. desensitization of receptor sites by contin-
ual exposure to the drug
D. antagonists produced by the body that
compete with the drug for receptor sites
6. What occurs when a drug binds to a receptor A. It increases or decreases the activity of
in the body? that receptor
A. It increases or decreases the activity of Correct! When a drug binds to a recep-
that receptor. tor, it mimics or blocks the actions of the
usual endogenous regulatory molecules,
B. It alters the receptor to become non- either increasing or decreasing the rate
responsive to its usual endogenous mole-
cules.
, WGU D116 Unit 2
Study online at https://quizlet.com/_e8ohaj
of the physiologic activity normally con-
C. It prevents the action of the receptor by trolled by that receptor.
altering its response to chemical mediators.
D. It gives the receptor a new function.
7. Which pharmacodynamic principle is most A. Therapeutic index
correlated with drug toxicity?
Which is calculated by dividing the me-
A. Therapeutic index dian toxic dose by the median efficacious
dose
B. Intrinsic activity
C. Competitive antagonists
D. Efficacy
8. A patient who is taking morphine for pain C. It is selective to receptors that regulate
asks the nurse how a pain medication can more than one body process
also cause constipation.
What is the nurse's response? Correct! Morphine is a medication that is
selective to receptor types that regulate
A. It binds to different types of receptors in more than one process.
the body.
B. It can cause constipation in toxic doses.
C. It is selective to receptors that regulate
more than one body process.
D. It causes only one type of response, and
the constipation is coincidental.
9.
