Hematology/Oncology
leukemia correct answersBone marrow produces immature blast
cells
WBCs that cannot function normally
if not treated within 2-4 months, patients will die from some sort
of infection ALL peaks 2-3 years
anemia, infection, nose, headaches, petechiae,
hepatosplenomegaly correct answersleukemia signs and
symptoms:
↓ RBC: - pallor, lethargy
↓ WBC:
↓ Platelet: bruising, bleeds,
, bone pain (thrombocytopenia)
CNS involvement: , vomiting,
papilledema
-fever (inflammatory response)
-anorexia/abdominal pain (r/t )
-weight loss, lymphadenopathy
-pallor/mucosal bleeding
-testicular masses
peripheral, spleen correct
answerscommon sites for leukemia:
-bone marrow
- blood
-CSF
- , liver
-testes, skin
,increased, decreased, decreased, LDH, uric acid, bone marrow
biopsy correct answersleukemia diagnosis:
- WBC (neutropenia)
- platelets (thrombocytopenia)
- hemoglobin (anemia)
- elevated
-high
confirmed diagnosis with
-lumbar puncture to r/o CNS involvement
-tumor markers, DNA testing, special stains> flow cytometry,
cytogenetics
-CBC & chemistry cannot diagnose alone
4.5-10 correct answersnormal WBC count in
thousands? 150-450 correct answersnormal platelet
count in thousands?
acute lymphocytic leukemia correct
answersimmature T and B cells
better than chronic because by the time they convert to chronic, bone
marrow does not respond well to chemo/treatments
2-9, 50, 30, 20, 50 correct answersfavorable prognostics for children
with acute lymphocytic leukemia:
ages -
pre-B
lineage
initial WBC
<
K
remission with induction therapy (high doses of chemo
initially) initial HCT >
initial PLT >
, hyperdiploid (> sets of chromosomes)
2, 10, refractory, T, CSF, 46 correct answersunfavorable prognostics
for acute lymphocytic leukemia:
age < or >
initial
WBC >50 K
chemo:
initial chemo
didn't work
cell
HCT
<30
PLT >20
blasts
in
TLS d/t
induction
hypodiploid (<
)
intrathecal
correct
answersleukemi
a treatment:
-chemotherapy
(3-4 years
duration)
-if CNS
involvement:
chemo
induction phase correct answersphase 1 of
chemo max cell death
consolidation phase correct answersphase 2 of
leukemia correct answersBone marrow produces immature blast
cells
WBCs that cannot function normally
if not treated within 2-4 months, patients will die from some sort
of infection ALL peaks 2-3 years
anemia, infection, nose, headaches, petechiae,
hepatosplenomegaly correct answersleukemia signs and
symptoms:
↓ RBC: - pallor, lethargy
↓ WBC:
↓ Platelet: bruising, bleeds,
, bone pain (thrombocytopenia)
CNS involvement: , vomiting,
papilledema
-fever (inflammatory response)
-anorexia/abdominal pain (r/t )
-weight loss, lymphadenopathy
-pallor/mucosal bleeding
-testicular masses
peripheral, spleen correct
answerscommon sites for leukemia:
-bone marrow
- blood
-CSF
- , liver
-testes, skin
,increased, decreased, decreased, LDH, uric acid, bone marrow
biopsy correct answersleukemia diagnosis:
- WBC (neutropenia)
- platelets (thrombocytopenia)
- hemoglobin (anemia)
- elevated
-high
confirmed diagnosis with
-lumbar puncture to r/o CNS involvement
-tumor markers, DNA testing, special stains> flow cytometry,
cytogenetics
-CBC & chemistry cannot diagnose alone
4.5-10 correct answersnormal WBC count in
thousands? 150-450 correct answersnormal platelet
count in thousands?
acute lymphocytic leukemia correct
answersimmature T and B cells
better than chronic because by the time they convert to chronic, bone
marrow does not respond well to chemo/treatments
2-9, 50, 30, 20, 50 correct answersfavorable prognostics for children
with acute lymphocytic leukemia:
ages -
pre-B
lineage
initial WBC
<
K
remission with induction therapy (high doses of chemo
initially) initial HCT >
initial PLT >
, hyperdiploid (> sets of chromosomes)
2, 10, refractory, T, CSF, 46 correct answersunfavorable prognostics
for acute lymphocytic leukemia:
age < or >
initial
WBC >50 K
chemo:
initial chemo
didn't work
cell
HCT
<30
PLT >20
blasts
in
TLS d/t
induction
hypodiploid (<
)
intrathecal
correct
answersleukemi
a treatment:
-chemotherapy
(3-4 years
duration)
-if CNS
involvement:
chemo
induction phase correct answersphase 1 of
chemo max cell death
consolidation phase correct answersphase 2 of
