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Exam (elaborations)

SBB Final Exam | Actual Questions and Answers Latest Updated 2024/2025 (Graded A+)

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SBB Final Exam | Actual Questions and Answers Latest Updated 2024/2025 (Graded A+)

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SBB Final Exam Review | Actual Questions and
Answers
macrocomplexloflproteinslincluding:
-Rh
-RhAG
-LWl(ICAM-4)
-GPA
-GPB
-CD47l-lBandl3

90%lfromlGlycolysisl(Embden-Meyerhofflpathway)
10%lfromlpentoselphosphatelpathwayl-lATPlsourcelforlRBCs

necessaryltolmaintainlhemelironlinlferrousl(Fe2+)lstate
Deficiencylcauseslaccumulationloflmethemoglobin,lnonfunctionallfromloflHgbl-
lMethemoglobinlReductaselPathway



permitslaccumulationlofl2,3-DPGl-lLeuberinglRapaportlShunt

DEOXYGENATED
wideningloflbeta-chain
lowerlaffinitylforlO2
expelsl2,3-DPGl-l"Tenselform"loflHgb

OXYGENATEDl
beta-chainlpulledltogether
higherlaffinitylforlO2
expelsl2,3-DPGl-l"Relaxedlform"loflHgb

higherlP50lvalue
decreasedlpHl(increasedlH+lion),lacidosis
increasedl2,3-DPG
higherltemperature
highlpCO2

Seenlinlcompensatedlanemial-l"ShiftlRight"

lowerlP50lvalue
increasedlpHl(decresedlH+lion),lalkalosis
decreasedel2,3-DPG
lowerltemeratures
lowlpCO2

SeenlinlstorageloflRBCl-l"ShiftlLeft"

,Gal-GlcNAc
B1-4l-lTypel2lprecursor

Gal-GlcNAc
B1-3

Secretedl(Se,lLe)l-lTypel1lprecursor

FUT-1

Alpha-2-L-fucosyltransferase

Fuctoselalpha1-2l-lTypel2lHlantigenltranseferasel&lSugar

D-galactosaminetrasferase

N-acetylgalactosaminelalpha1-3l-lAlantigenltransferasel&lsugar

D-galacotsyltransferase

galactoselalpha1-3l-lBlantigenltransferasel&lsugar

weaklylpositivelanti-A
weaklylpositivelanti-A,Bl-lAxlsubgroup

Negativelanti-A
SecreteslAl&lHl-lAmlsubgroup

Negativelanti-A
SecreteslHlonlyl-lAellsubgroup

O>A2>B>A2B>A1>A1B>lHldeficientl-lHighestlexpressionloflH
LowestlexpressionloflH

FUT-3

Fuctoselalpha1-4l-lLewisltransferasel&lSugar

FUT-2

Fuctoselalpha1-2l-lTypel1lHlantigenltransferasel&lsugar

Anti-Lelbh=lreactslbestlwithlLebl&lHlarelonlrbc
reactslbestlwithlgrouplOlandlA2
doeslnotlreactlwithlA1l&lB

, Anti-Lelbl=lreactslindependentlyloflamountloflHlonlrbc
bestlantiseraltoluselwhenltypinglRBCl-lanti-Lelbhlvslanti-Lelbl

A1lpatients,lhavelthelleastlamountloflHl-lautoanti-H,l-HIlislmostlcommonlin...

cordlcells
reticulocyteslinlmegaloblasticlanemia
leukemial
stressedlerythropoiesisl-lElevatedlilantigenlassociatedlwith...

IGnT
addslGlcNAcltolGal
startslbranching/lmultivalentl-lIlgene

infectiouslmonol-lanti-ilassociatedlwithlwhatldisease

Mycoplasmalpneumoniaelinfectionsl
Lymphoproliferativeldisorderl(Waldenstromlmacroglobinemia)l-lautoanti-i,l-
Ilcommonlylseenlinlpatientslwith....

B3GalNAct1

missinglPlantigenl(alsolGb5l&lLKE)l-lP1Kl&lP2Kllacklwhatlgene/lantigen

A4GALT

missinglP1/PX2l&lPkl(alsolP,lGb5l&LKE)l-lpllacklwhatlgene/lantigen

Hydaitedlcyst
Birdleggs
liverlflukel-lP1lsubstancelderivedlfrom...

ParoxysamallColdlHemoglobinuria,lPCH

DonathlLandsteinerl-lautoanti-Plassociatedlwith

Enzyme=lDecreasedl-lLutheranl(E/DTT)

Enzyme=lincreasedl-lLewisl(E/DTT)

unaffectedlbylbothl-lDiegol(E/DTT)

Enzyme=ldecreased
DTT=ldecreasedl-lYtl(E/DTT)

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