Immunotherapy
Guide _ Drug
MedChem
Design, Mechanisms
Study
Immunotherapy
Guide &_ Cancer
Drug
MedChem
Design,
Therapeutics.pdf
Mechanisms
Study Guide &_ Cancer
Drug Design,
Therapeutics.pdf
Mechanisms & Cancer Therapeutics.pdf
Immunotherapy MedChem Study Guide
| Drug Design, Mechanisms & Cancer
Therapeutics
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Immunotherapy MedChem Study
Immunotherapy
Guide _ Drug
MedChem
Design, Mechanisms
Study
Immunotherapy
Guide &_ Cancer
Drug
MedChem
Design,
Therapeutics.pdf
Mechanisms
Study Guide &_ Cancer
Drug Design,
Therapeutics.pdf
Mechanisms & Cancer Therapeutics.pdf
,Immunotherapy MedChem.pdf Immunotherapy MedChem.pdf Immunotherapy MedChem.pdf
Terms in this set (37)
Ibritumomab MOA anti-CD20 linked to radioisotopes
Causes tumor cell death via ADCC, complement-mediated cytotoxicity
(CMC), and beta-radiation
Ibritumomab Inidcation B-cell non-Hodgkin lymphoma
Cetuximab MOA anti-EGFR monoclonal antibody
Blocks EGFR signaling → inhibits tumor growth
mediates ADCC and CMC
Immunotherapy MedChem.pdf Immunotherapy MedChem.pdf Immunotherapy MedChem.pdf
,Immunotherapy MedChem.pdf Immunotherapy MedChem.pdf Immunotherapy MedChem.pdf
Cetuximab Inidcation Colorectal cancer
Head and neck cancer
Bevacizumab MOA Humanized mAb against VEGF
Prevents VEGF from binding VEGF receptors → inhibits tumor angiogenesis
Bevacizumab Inidcation colorectal, lung, renal, ovarian, breast, brain cancers
Trastuzumab MOA anti-HER2 mAb
Inhibits HER2 signaling and induces ADCC
Trastuzumab Inidcation HER2-positive breast cancer
Immunotherapy MedChem.pdf Immunotherapy MedChem.pdf Immunotherapy MedChem.pdf
, Immunotherapy MedChem.pdf Immunotherapy MedChem.pdf Immunotherapy MedChem.pdf
Rituximab MOA anti-CD20 mAb
Induces ADCC and CMC
Rituximab Inidcation B-cell NHL, CLL, rheumatoid arthritis (and off-label autoimmune uses)
antibody drug conjugates bind to antibody → antibody binds target → antibody cleaves → cytotoxic
in lysosome
Drugs: Brentuximab
vedotin, Ado-Trastuzumab Emtansine and Gemtuzumab Ozogamicin
Immunotherapy MedChem.pdf Immunotherapy MedChem.pdf Immunotherapy MedChem.pdf