CPHON Review UPDATED ACTUAL Exam
Questions and CORRECT Answers
Leukemia - CORRECT ANSWER - the uncontrolled production of white blood cells
Age group ALL is most common in - CORRECT ANSWER - 2-4 years
Age group AML is most common in - CORRECT ANSWER - neonates and teens
Most common type of childhood leukemia - CORRECT ANSWER - ALL
Increased risk for ALL - CORRECT ANSWER - white, male, living in Western countries,
Downs
Increased risk for AML - CORRECT ANSWER - hispanic or black, maternal cig
smoking/alcohol abuse, exposure to VP16, Downs, NFI, Monosomy 7
Signs of TLS - CORRECT ANSWER - elevated LDH, elevated Uric acid, elevated K,
elevated Phos, low Calcium
Cytochemistry stains (+) in AML dx - CORRECT ANSWER - Myeloperoxidase and
Sudan Black
Auer Rods - CORRECT ANSWER - Only seen in AML cell stains
Immunophenotyping helps determine between - CORRECT ANSWER - ALL vs AML, T-
cell vs B-cell, early pre-B vs pre-B, etc.
CNS 1 - CORRECT ANSWER - No blasts or WBC in CSF
,CNS 2 - CORRECT ANSWER - <5 WBC and <5 blasts
CNS 3 - CORRECT ANSWER - >5 WBC and >5 blasts, +/- CNS leuk signs and
symptoms
< 50,000 WBC at dx - CORRECT ANSWER - SR
>50,000 WBC at dx - CORRECT ANSWER - HR
1-9 years old at dx - CORRECT ANSWER - SR
<1 year and =>10 years old at dx - CORRECT ANSWER - HR
Slow early response to chemo during induction and consolidation - CORRECT
ANSWER - HR
Rapid early response to chemo during induction and consolidation - CORRECT
ANSWER - SR
ALL Induction - CORRECT ANSWER - First phase, goal = marrow remission, eliminate
blasts, >97% achieve remission
Induction for ALL Agents - CORRECT ANSWER - VCR, steroids, asparaginase,
anthracyclines
Consolidation/Intensification for ALL - CORRECT ANSWER - goal= eradicate remaining
leukemia, treat sanctuary sites and intensity tx of CNS (IT and or XRT) *3 weeks in a row of
CNS tx w LP & ITs
, Consolidation/Intensification for ALL Agents - CORRECT ANSWER - cytox, ARA-C,
6MP, VCR, Peg, ITs
Maintenance for ALL - CORRECT ANSWER - goal= remain in remission, mostly out
patient (IM, DI, Maint.),
IM Agents for ALL - CORRECT ANSWER - VCR, MTX, PEG, ITs
DI Agents for ALL - CORRECT ANSWER - Cytox, ARAC, 6TG, VCR, Dox, Peg, ITS,
need lots of tranfx and CBC checks
Maintenance Agents for ALL - CORRECT ANSWER - Dosing based on counts; VCR, PO
steroids, PO 6MP, PO MTX
ALL early relapse - CORRECT ANSWER - <6 mo off therapy
ALL late relapse - CORRECT ANSWER - >6 mo off therapy
Blinatumomab - CORRECT ANSWER - targets CD19 antigen on B cells
AML survival rate - CORRECT ANSWER - 40-50%
AML Therapy - CORRECT ANSWER - intense chemo with increased risk of infection,
isolate
AML therapy agents - CORRECT ANSWER - anthracyclines, HD ARA-C, Asparaginase,
steroids, thioguanine, CNS prophylaxis w ARAC
AML Relapse without prior BMT - CORRECT ANSWER - will go to URD PSCT
Questions and CORRECT Answers
Leukemia - CORRECT ANSWER - the uncontrolled production of white blood cells
Age group ALL is most common in - CORRECT ANSWER - 2-4 years
Age group AML is most common in - CORRECT ANSWER - neonates and teens
Most common type of childhood leukemia - CORRECT ANSWER - ALL
Increased risk for ALL - CORRECT ANSWER - white, male, living in Western countries,
Downs
Increased risk for AML - CORRECT ANSWER - hispanic or black, maternal cig
smoking/alcohol abuse, exposure to VP16, Downs, NFI, Monosomy 7
Signs of TLS - CORRECT ANSWER - elevated LDH, elevated Uric acid, elevated K,
elevated Phos, low Calcium
Cytochemistry stains (+) in AML dx - CORRECT ANSWER - Myeloperoxidase and
Sudan Black
Auer Rods - CORRECT ANSWER - Only seen in AML cell stains
Immunophenotyping helps determine between - CORRECT ANSWER - ALL vs AML, T-
cell vs B-cell, early pre-B vs pre-B, etc.
CNS 1 - CORRECT ANSWER - No blasts or WBC in CSF
,CNS 2 - CORRECT ANSWER - <5 WBC and <5 blasts
CNS 3 - CORRECT ANSWER - >5 WBC and >5 blasts, +/- CNS leuk signs and
symptoms
< 50,000 WBC at dx - CORRECT ANSWER - SR
>50,000 WBC at dx - CORRECT ANSWER - HR
1-9 years old at dx - CORRECT ANSWER - SR
<1 year and =>10 years old at dx - CORRECT ANSWER - HR
Slow early response to chemo during induction and consolidation - CORRECT
ANSWER - HR
Rapid early response to chemo during induction and consolidation - CORRECT
ANSWER - SR
ALL Induction - CORRECT ANSWER - First phase, goal = marrow remission, eliminate
blasts, >97% achieve remission
Induction for ALL Agents - CORRECT ANSWER - VCR, steroids, asparaginase,
anthracyclines
Consolidation/Intensification for ALL - CORRECT ANSWER - goal= eradicate remaining
leukemia, treat sanctuary sites and intensity tx of CNS (IT and or XRT) *3 weeks in a row of
CNS tx w LP & ITs
, Consolidation/Intensification for ALL Agents - CORRECT ANSWER - cytox, ARA-C,
6MP, VCR, Peg, ITs
Maintenance for ALL - CORRECT ANSWER - goal= remain in remission, mostly out
patient (IM, DI, Maint.),
IM Agents for ALL - CORRECT ANSWER - VCR, MTX, PEG, ITs
DI Agents for ALL - CORRECT ANSWER - Cytox, ARAC, 6TG, VCR, Dox, Peg, ITS,
need lots of tranfx and CBC checks
Maintenance Agents for ALL - CORRECT ANSWER - Dosing based on counts; VCR, PO
steroids, PO 6MP, PO MTX
ALL early relapse - CORRECT ANSWER - <6 mo off therapy
ALL late relapse - CORRECT ANSWER - >6 mo off therapy
Blinatumomab - CORRECT ANSWER - targets CD19 antigen on B cells
AML survival rate - CORRECT ANSWER - 40-50%
AML Therapy - CORRECT ANSWER - intense chemo with increased risk of infection,
isolate
AML therapy agents - CORRECT ANSWER - anthracyclines, HD ARA-C, Asparaginase,
steroids, thioguanine, CNS prophylaxis w ARAC
AML Relapse without prior BMT - CORRECT ANSWER - will go to URD PSCT
