Test bank for Tietz Fundamentals of Clinical Chemistry
and Molecular Diagnostics,
8th Edition by Nader Rifai, PhD
Chapters 1 - 49
,Tietz Fundamentals of Clinical Chemistry and Molecular Diagnostics 8th Edition Test Bank
,Chapter 01: Clinical Chemistry, Molecular Diagnostics, and Laboratory Medicine
TestBank
MULTIPLE CHOICE
1. An individual working in a clinical chemistry laboratory is married to a sales representative
who works for a company that sells chemistry laboratory supplies. When the laboratory
manager requests a list of needed supplies, cost of supplies, and vendors, this individual only
recommends the spouse’s company as the vendor. This is considered to be a(n):
a. accounting issue.
b. possible conflict of interest.
c. maintenance of confidentiality issue.
d. problem with resource allocation.
ANS: B
Concern has been raised over the interrelationships between practitioners in the medical field
and commercial suppliers of drugs, devices, equipment, etc., to the medical profession.
Similarly, relationships have been scrutinized between clinical laboratorians and
manufacturers and providers of diagnostic equipment and supplies. These concerns led the
National Institutes of Health (NIH) in 1995 to require official institutional review of financial
disclosure by researchers and management of situations in which disclosure indicates potential
conflicts of interest.
DIF: 1 REF: Page 4-5 OBJ: 6 | 7
2. A patient visits her physician stating that her prescribed painkiller is not working to reduce
the pain following her recent surgery. A friend of the patient claims that the same painkiller
“worked wonders” to reduce her pain after the same surgery. The physician states that the
difference in the effect of the drug might be caused by , which is studied in
pharmacogenetics.
a. epidemiology
b. an inherited disease
c. a conflict of interest
d. a genetic variation in drug-metabolizing enzymes
ANS: D
Pharmacogenetics is the study of the genetic variation of drug metabolism between
individuals.
DIF: 1 REF: Page 3 OBJ: 1
3. John works in a molecular diagnostics laboratory and receives a blood sample that has the
name of a close friend printed on the bar-coded label. The genetic test that is ordered on the
friend’s sample would provide diagnostic information about a disorder that has a poor
prognosis, and the test is usually performed by John. He asks a fellow employee to analyze
the sample for him and not divulge the results. This ethical issue concerns:
a. confidentiality of patient genetic and medical information.
b. a conflict of interest.
c. resource allocation.
d. diagnostic accuracy.
, ANS: A
Clinical laboratorians have long been responsible for maintaining the confidentiality of all
laboratory results, a situation made even more critical with the advent of increasingly
powerful genetic testing.
DIF: 1 REF: Page 4 OBJ: 6 | 7
4. Molecular diagnostic testing methods and results can be:
a. qualitative only.
b. quantitative only.
c. either qualitative or quantitative.
ANS: C
Molecular diagnostic methods can be either qualitative or quantitative in nature, depending on
the clinical need.
DIF: 1 REF: Page 3 OBJ: 5
5. Clinical epidemiology, which is the study of the patterns, causes, and effects of health and
disease in certain populations, has provided the clinical laboratory with methods that evaluate
the effects and outcomes of laboratory testing. This allows for a more effective:
a. process of determining the cost of the testing methods.
b. selection and interpretation of laboratory tests.
c. determination of the boundaries between the components of the clinical lab.
d. conduct assessment.
ANS: A
Clinical epidemiologists have introduced methods to evaluate the effects and value of
laboratory testing in healthcare. These developments are expected to play an increasing role in
the selection and interpretation of laboratory tests.
DIF: 1 REF: Page 3 OBJ: 4
6. Analysis of which one of the following by molecular diagnostic methods provides a measure
of processes that are ongoing at the time of blood sampling?
a. Genetic variation in an individual’s response to a drug
b. Circulating plasma nucleic acids
c. Malignant lymphomas
d. Histocompatibility
ANS: B
Molecular diagnostics, given its very high sensitivity, has been applied to the study of plasma
nucleic acids (or circulating nucleic acids). Plasma nucleic acids analysis has been made
possible by the discovery that dying cells in the body release their DNA and RNA into the
extracellular compartment and ultimately into the bloodstream, where they can be detected
and analyzed. Given their short half-life in circulation (less than 24 hours), plasma nucleic
acids provide a measure of processes that are ongoing at the time of blood sampling.
DIF: 1 REF: Page 3 OBJ: 5
and Molecular Diagnostics,
8th Edition by Nader Rifai, PhD
Chapters 1 - 49
,Tietz Fundamentals of Clinical Chemistry and Molecular Diagnostics 8th Edition Test Bank
,Chapter 01: Clinical Chemistry, Molecular Diagnostics, and Laboratory Medicine
TestBank
MULTIPLE CHOICE
1. An individual working in a clinical chemistry laboratory is married to a sales representative
who works for a company that sells chemistry laboratory supplies. When the laboratory
manager requests a list of needed supplies, cost of supplies, and vendors, this individual only
recommends the spouse’s company as the vendor. This is considered to be a(n):
a. accounting issue.
b. possible conflict of interest.
c. maintenance of confidentiality issue.
d. problem with resource allocation.
ANS: B
Concern has been raised over the interrelationships between practitioners in the medical field
and commercial suppliers of drugs, devices, equipment, etc., to the medical profession.
Similarly, relationships have been scrutinized between clinical laboratorians and
manufacturers and providers of diagnostic equipment and supplies. These concerns led the
National Institutes of Health (NIH) in 1995 to require official institutional review of financial
disclosure by researchers and management of situations in which disclosure indicates potential
conflicts of interest.
DIF: 1 REF: Page 4-5 OBJ: 6 | 7
2. A patient visits her physician stating that her prescribed painkiller is not working to reduce
the pain following her recent surgery. A friend of the patient claims that the same painkiller
“worked wonders” to reduce her pain after the same surgery. The physician states that the
difference in the effect of the drug might be caused by , which is studied in
pharmacogenetics.
a. epidemiology
b. an inherited disease
c. a conflict of interest
d. a genetic variation in drug-metabolizing enzymes
ANS: D
Pharmacogenetics is the study of the genetic variation of drug metabolism between
individuals.
DIF: 1 REF: Page 3 OBJ: 1
3. John works in a molecular diagnostics laboratory and receives a blood sample that has the
name of a close friend printed on the bar-coded label. The genetic test that is ordered on the
friend’s sample would provide diagnostic information about a disorder that has a poor
prognosis, and the test is usually performed by John. He asks a fellow employee to analyze
the sample for him and not divulge the results. This ethical issue concerns:
a. confidentiality of patient genetic and medical information.
b. a conflict of interest.
c. resource allocation.
d. diagnostic accuracy.
, ANS: A
Clinical laboratorians have long been responsible for maintaining the confidentiality of all
laboratory results, a situation made even more critical with the advent of increasingly
powerful genetic testing.
DIF: 1 REF: Page 4 OBJ: 6 | 7
4. Molecular diagnostic testing methods and results can be:
a. qualitative only.
b. quantitative only.
c. either qualitative or quantitative.
ANS: C
Molecular diagnostic methods can be either qualitative or quantitative in nature, depending on
the clinical need.
DIF: 1 REF: Page 3 OBJ: 5
5. Clinical epidemiology, which is the study of the patterns, causes, and effects of health and
disease in certain populations, has provided the clinical laboratory with methods that evaluate
the effects and outcomes of laboratory testing. This allows for a more effective:
a. process of determining the cost of the testing methods.
b. selection and interpretation of laboratory tests.
c. determination of the boundaries between the components of the clinical lab.
d. conduct assessment.
ANS: A
Clinical epidemiologists have introduced methods to evaluate the effects and value of
laboratory testing in healthcare. These developments are expected to play an increasing role in
the selection and interpretation of laboratory tests.
DIF: 1 REF: Page 3 OBJ: 4
6. Analysis of which one of the following by molecular diagnostic methods provides a measure
of processes that are ongoing at the time of blood sampling?
a. Genetic variation in an individual’s response to a drug
b. Circulating plasma nucleic acids
c. Malignant lymphomas
d. Histocompatibility
ANS: B
Molecular diagnostics, given its very high sensitivity, has been applied to the study of plasma
nucleic acids (or circulating nucleic acids). Plasma nucleic acids analysis has been made
possible by the discovery that dying cells in the body release their DNA and RNA into the
extracellular compartment and ultimately into the bloodstream, where they can be detected
and analyzed. Given their short half-life in circulation (less than 24 hours), plasma nucleic
acids provide a measure of processes that are ongoing at the time of blood sampling.
DIF: 1 REF: Page 3 OBJ: 5
