NRNP 6675 FINAL EXAM WITH ALL
ANSWERS
1. The b1/2 blife bof blithium bis babout? 24 bhours
2. Fluoxetine bis bthe bSSRI bwith bthe b WD lowest bdue bto blong bhalf
brisk?
blife
3. What bantipsychotics bare bgood bfor bpts
bwho bmiss bdoses bof btheir bmeds?
Antipsychotics bwith
blong bhalf-lives:
1.Cariprazine(Vrylar):
b(2-4 bdays-active
bmetabolites bup bto b3
bweeks)
2.Abilify b(3 bdays)
3.Brexipiprazole b(4 bdays)
4.Pimozide b(4-5 bdays)
5.Pimavanserin b(2 bdays,
4. Disulfiram's balcohol binteractions bpersist bac- btive bmetabolites b8
bfor bup bto bhow blong bafter bthe bmedication
bdays)
bis bstopped?
1 b/
b44
,LONG bHalf blife--2-3 bdays persist bup bto b2 bweeks
bfollow- bing bstopping
5. What bis bthe bonly bTCA bwith ba blong bhalf blife?Protriptyline b(Vivactil)
6. Most bpsychotropics bhave ba bmedium 24 bhours
brange b1/2 blife bof bapprox?
7. what bdoes b"steady bstate" bmean bin brelation steady bstate bmeans
bto b1/2 blife? bthat byou bare
beliminating bthe bdrug bat
bthe bsame boverall brate
bthat byou bare bingesting
bit
8. Lithium breaches bits b'steady bstate' bwhen? 5 bhalf blives
example:
Day b1: bStart bpt bon
bLithium b600 bmg bdaily
Day b2: b(24 bhours blater)
bthe bamount bleft bin bhis
bbody bis b300 bmg b(day b2
bmin) bbecause b24 bhours
bhas bpassed--one
2 b/
b44
, 1/2 blife--therefore bthe bpt
bhas bexcreted b1/2 bof bthe
binitial bamount.
THEN bthe bpt btakes bhis
b2nd bdose bof b600 bmg bon
bDAY b2-re- bsulting bin ba
bmax bdose bof b900 b(300
bmg bleft bin bbody b+ b600
bmg bof b2nd bdose).
DAY b3: bstarts boff bwith
b450 bmg b(1/2 bof bthe b900
bmg bin bpt's bsys- btem)
band bafter btaking bthe
bday b3 b600 bmg bdose,
9. Due bto bthe bsteady bstate bof bLithium, bwhen bthe bpt bnow bhas ba btotal
bdo bwe bdraw ba bblood blevel? bof b1050 bmg.
5 bhalf blives
if byou bcheck bany bearlier,
bthe btrough blevel bwill
bunderesti- bmate bthe
bactual blevel bthe bpt bis
bon bafter bachieving
bsteady bstate
10. Fluoxetine bhas ba bhalf blife bof babout? 2 bweeks b1/2 blife
take b2.5 bmonths bto
bachieve bsteady bstate
11. Most bpsychotropic bmedications boperate 12. induces bit
bin bthis bfashion: bown bmetabolism,
bhastening bexcretion
band bshortening bit's
bhalf blife
3 b/
b44
,"when byou bdouble bthe bdose, bthe bserum
bdose bdoubles."
*minus bthree bSRIs band bthree
banticonvulsants b(Flu- boxetine,
bfluvoxamine, bpaxil, bgabapentin, bvalproate
band bcarbamazepine)
A. bCarbamazepine b(Tegre- btol)
*this beffect bbegins bto b"rev
4 b/
b44
ANSWERS
1. The b1/2 blife bof blithium bis babout? 24 bhours
2. Fluoxetine bis bthe bSSRI bwith bthe b WD lowest bdue bto blong bhalf
brisk?
blife
3. What bantipsychotics bare bgood bfor bpts
bwho bmiss bdoses bof btheir bmeds?
Antipsychotics bwith
blong bhalf-lives:
1.Cariprazine(Vrylar):
b(2-4 bdays-active
bmetabolites bup bto b3
bweeks)
2.Abilify b(3 bdays)
3.Brexipiprazole b(4 bdays)
4.Pimozide b(4-5 bdays)
5.Pimavanserin b(2 bdays,
4. Disulfiram's balcohol binteractions bpersist bac- btive bmetabolites b8
bfor bup bto bhow blong bafter bthe bmedication
bdays)
bis bstopped?
1 b/
b44
,LONG bHalf blife--2-3 bdays persist bup bto b2 bweeks
bfollow- bing bstopping
5. What bis bthe bonly bTCA bwith ba blong bhalf blife?Protriptyline b(Vivactil)
6. Most bpsychotropics bhave ba bmedium 24 bhours
brange b1/2 blife bof bapprox?
7. what bdoes b"steady bstate" bmean bin brelation steady bstate bmeans
bto b1/2 blife? bthat byou bare
beliminating bthe bdrug bat
bthe bsame boverall brate
bthat byou bare bingesting
bit
8. Lithium breaches bits b'steady bstate' bwhen? 5 bhalf blives
example:
Day b1: bStart bpt bon
bLithium b600 bmg bdaily
Day b2: b(24 bhours blater)
bthe bamount bleft bin bhis
bbody bis b300 bmg b(day b2
bmin) bbecause b24 bhours
bhas bpassed--one
2 b/
b44
, 1/2 blife--therefore bthe bpt
bhas bexcreted b1/2 bof bthe
binitial bamount.
THEN bthe bpt btakes bhis
b2nd bdose bof b600 bmg bon
bDAY b2-re- bsulting bin ba
bmax bdose bof b900 b(300
bmg bleft bin bbody b+ b600
bmg bof b2nd bdose).
DAY b3: bstarts boff bwith
b450 bmg b(1/2 bof bthe b900
bmg bin bpt's bsys- btem)
band bafter btaking bthe
bday b3 b600 bmg bdose,
9. Due bto bthe bsteady bstate bof bLithium, bwhen bthe bpt bnow bhas ba btotal
bdo bwe bdraw ba bblood blevel? bof b1050 bmg.
5 bhalf blives
if byou bcheck bany bearlier,
bthe btrough blevel bwill
bunderesti- bmate bthe
bactual blevel bthe bpt bis
bon bafter bachieving
bsteady bstate
10. Fluoxetine bhas ba bhalf blife bof babout? 2 bweeks b1/2 blife
take b2.5 bmonths bto
bachieve bsteady bstate
11. Most bpsychotropic bmedications boperate 12. induces bit
bin bthis bfashion: bown bmetabolism,
bhastening bexcretion
band bshortening bit's
bhalf blife
3 b/
b44
,"when byou bdouble bthe bdose, bthe bserum
bdose bdoubles."
*minus bthree bSRIs band bthree
banticonvulsants b(Flu- boxetine,
bfluvoxamine, bpaxil, bgabapentin, bvalproate
band bcarbamazepine)
A. bCarbamazepine b(Tegre- btol)
*this beffect bbegins bto b"rev
4 b/
b44
