Tuberculosis Exam Questions with 100%
Correct Answers | Graded A+
Which of the following would be the BEST initial TB treatment for a patient
newly diagnosed with HIV initiating ART?
Rifabutin + isoniazid + ethionamide + pyrazinamide
Rifabutin + isoniazid + ethambutol + pyrazinamide
Rifampin + isoniazid + ethambutol + pyrazinamide
Moxifloxacin + isoniazid + ethionamide + pyrazinamide - ✔✔Rifampin +
isoniazid + ethambutol + pyrazinamide
Which of the following would be the BEST drug(s) to add onto a patient's
regimen if MDR-TB is suspected?
Moxifloxacin
Capreomycin
Levofloxacin + amikacin
Moxifloxacin + cycloserine - ✔✔Levofloxacin + amikacin
1
©NINJANERD 2025/2026. YEAR PUBLISHED 2025.
,The addition of which of the following drugs necessitates follow-up liver
function tests in a patient being treated for latent TB infection treated with
isoniazid?
Naproxen
Multivitamin
Sertraline
Acetaminophen
Lisinopril - ✔✔Acetaminophen
JK is a 32-year-old HIV-negative patient presenting to your clinic. He
receives a Mantoux skin test that returns positive 2 days later. He was born
in the United States and works as a prison guard. He injects heroin on a
regular basis. His chest x-ray comes back normal, he has no symptoms of
tuberculosis, and his smear culture is negative. What type of drug therapy
would be appropriate for this patient?
Isoniazid 300 mg daily × 9 months
Rifampin 100 mg daily × 4 months
No drug therapy needed
Isoniazid 300 mg and rifampin 600 mg × 6 months
2
©NINJANERD 2025/2026. YEAR PUBLISHED 2025.
, Isoniazid, rifampin, ethambutol, and pyrazinamide - ✔✔Isoniazid 300 mg
daily × 9 months
Which patient group should get drug-susceptibility testing?
All latent tuberculosis patients
Latent tuberculosis patients over age 35
All active tuberculosis disease patients
Active tuberculosis patients over age 35
Foreign-born cases of latent and active tuberculosis - ✔✔All active
tuberculosis disease patients
RS is a 25-year-old Hispanic woman who is recently diagnosed with active
tuberculosis. Her physician asks what drug regimen you would recommend
to treat her disease? She does not have any contraindications to any of the
tuberculosis medications. You do not have susceptibility testing back yet.
INH, RIF, PZA × 8 weeks, then INH, RIF × 18 weeks
INH × 9 months
INH, RIF × 9 months
INH, RIF, EMB, FQ × 8 weeks, then INH, RIF × 18 weeks
3
©NINJANERD 2025/2026. YEAR PUBLISHED 2025.
Correct Answers | Graded A+
Which of the following would be the BEST initial TB treatment for a patient
newly diagnosed with HIV initiating ART?
Rifabutin + isoniazid + ethionamide + pyrazinamide
Rifabutin + isoniazid + ethambutol + pyrazinamide
Rifampin + isoniazid + ethambutol + pyrazinamide
Moxifloxacin + isoniazid + ethionamide + pyrazinamide - ✔✔Rifampin +
isoniazid + ethambutol + pyrazinamide
Which of the following would be the BEST drug(s) to add onto a patient's
regimen if MDR-TB is suspected?
Moxifloxacin
Capreomycin
Levofloxacin + amikacin
Moxifloxacin + cycloserine - ✔✔Levofloxacin + amikacin
1
©NINJANERD 2025/2026. YEAR PUBLISHED 2025.
,The addition of which of the following drugs necessitates follow-up liver
function tests in a patient being treated for latent TB infection treated with
isoniazid?
Naproxen
Multivitamin
Sertraline
Acetaminophen
Lisinopril - ✔✔Acetaminophen
JK is a 32-year-old HIV-negative patient presenting to your clinic. He
receives a Mantoux skin test that returns positive 2 days later. He was born
in the United States and works as a prison guard. He injects heroin on a
regular basis. His chest x-ray comes back normal, he has no symptoms of
tuberculosis, and his smear culture is negative. What type of drug therapy
would be appropriate for this patient?
Isoniazid 300 mg daily × 9 months
Rifampin 100 mg daily × 4 months
No drug therapy needed
Isoniazid 300 mg and rifampin 600 mg × 6 months
2
©NINJANERD 2025/2026. YEAR PUBLISHED 2025.
, Isoniazid, rifampin, ethambutol, and pyrazinamide - ✔✔Isoniazid 300 mg
daily × 9 months
Which patient group should get drug-susceptibility testing?
All latent tuberculosis patients
Latent tuberculosis patients over age 35
All active tuberculosis disease patients
Active tuberculosis patients over age 35
Foreign-born cases of latent and active tuberculosis - ✔✔All active
tuberculosis disease patients
RS is a 25-year-old Hispanic woman who is recently diagnosed with active
tuberculosis. Her physician asks what drug regimen you would recommend
to treat her disease? She does not have any contraindications to any of the
tuberculosis medications. You do not have susceptibility testing back yet.
INH, RIF, PZA × 8 weeks, then INH, RIF × 18 weeks
INH × 9 months
INH, RIF × 9 months
INH, RIF, EMB, FQ × 8 weeks, then INH, RIF × 18 weeks
3
©NINJANERD 2025/2026. YEAR PUBLISHED 2025.
