APEA- Psych Pharm
Bupropion (Wellbutrin), used in the treatment of depression, should NOT be administered to a patient
with:
alcoholism.
attention deficit disorder.
hypertension.
seizure disorder. - ✔✔ correct answer seizure disorder.
First-generation antipsychotics (e.g., haloperidol [Haldol]) are associated with side effects including:
sedation.
tardive dyskinesia.
weight gain.
weight loss. - ✔✔ correct answer tardive dyskinesia.
If methylphenidate is contraindicated, which of the following medications is recommended for treatment
of ADHD in an adult?
Bupropion (Wellbutrin)
Clonazepam (Klonopin)
Fluoxetine (Prozac)
Phenelzine (Nardil) - ✔✔ correct answer Bupropion (Wellbutrin)
Therapeutic drug levels and predictability of clinical response are difficult to determine in first-
generation antipsychotics (e.g., haloperidol [Haldol]) because they:
are poorly absorbed in the intestines, hydrophilic and highly protein bound.
are highly bioavailable and poorly protein bound.
have a decreased first pass effect, are hydrophilic and poorly protein bound.
have variable bioavailability, are lipophilic and highly protein bound. - ✔✔ correct answer have variable
bioavailability, are lipophilic and highly protein bound.
Guanfacine (Intuniv), used in the treatment of attention deficit disorder, is classified as a(n):
alpha-2-adrenergic agonist.
, APEA- Psych Pharm
selective norepinephrine reuptake inhibitor.
sympathomimetic/stimulant.
tricyclic antidepressant. - ✔✔ correct answer alpha-2-adrenergic agonist.
Suvorexant (Belsomra), used in the treatment of insomnia, induces sleep by:
activating melatonin receptors.
blocking the signals of orexin chemicals in the hypothalamus.
increasing the catabolism of tryptophan.
raising the levels of gamma-aminobutyric acid (GABA). - ✔✔ correct answer blocking the signals of
orexin chemicals in the hypothalamus.
The mechanism of action of second-generation antipsychotic medications such as aripiprazole (Abilify)
does NOT include:
5-HT2A receptor blockade.
dopamine D2 receptor blockade.
serotonin reuptake stimulation.
enhanced dopamine release. - ✔✔ correct answer serotonin reuptake stimulation.
After initiation or increase in dose of a selective serotonin receptor inhibitor (SSRI) such as escitalopram
(Lexapro), the patient should be monitored for:
agitation, hypersalivation and decreased bowel sounds.
hypothermia, dilated pupils and diaphoresis.
hyperthermia, akathisia and clonus.
lead pipe rigidity, hyporeflexia and tachypnea. - ✔✔ correct answer hyperthermia, akathisia and clonus.
Which statement about naltrexone (Vivitrol) is correct?
The patient may develop tolerance to naltrexone.
Naltrexone should be tapered once desired results are achieved.
The patient should be aware that a possible "rebound" effect may occur after discontinuation.
Bupropion (Wellbutrin), used in the treatment of depression, should NOT be administered to a patient
with:
alcoholism.
attention deficit disorder.
hypertension.
seizure disorder. - ✔✔ correct answer seizure disorder.
First-generation antipsychotics (e.g., haloperidol [Haldol]) are associated with side effects including:
sedation.
tardive dyskinesia.
weight gain.
weight loss. - ✔✔ correct answer tardive dyskinesia.
If methylphenidate is contraindicated, which of the following medications is recommended for treatment
of ADHD in an adult?
Bupropion (Wellbutrin)
Clonazepam (Klonopin)
Fluoxetine (Prozac)
Phenelzine (Nardil) - ✔✔ correct answer Bupropion (Wellbutrin)
Therapeutic drug levels and predictability of clinical response are difficult to determine in first-
generation antipsychotics (e.g., haloperidol [Haldol]) because they:
are poorly absorbed in the intestines, hydrophilic and highly protein bound.
are highly bioavailable and poorly protein bound.
have a decreased first pass effect, are hydrophilic and poorly protein bound.
have variable bioavailability, are lipophilic and highly protein bound. - ✔✔ correct answer have variable
bioavailability, are lipophilic and highly protein bound.
Guanfacine (Intuniv), used in the treatment of attention deficit disorder, is classified as a(n):
alpha-2-adrenergic agonist.
, APEA- Psych Pharm
selective norepinephrine reuptake inhibitor.
sympathomimetic/stimulant.
tricyclic antidepressant. - ✔✔ correct answer alpha-2-adrenergic agonist.
Suvorexant (Belsomra), used in the treatment of insomnia, induces sleep by:
activating melatonin receptors.
blocking the signals of orexin chemicals in the hypothalamus.
increasing the catabolism of tryptophan.
raising the levels of gamma-aminobutyric acid (GABA). - ✔✔ correct answer blocking the signals of
orexin chemicals in the hypothalamus.
The mechanism of action of second-generation antipsychotic medications such as aripiprazole (Abilify)
does NOT include:
5-HT2A receptor blockade.
dopamine D2 receptor blockade.
serotonin reuptake stimulation.
enhanced dopamine release. - ✔✔ correct answer serotonin reuptake stimulation.
After initiation or increase in dose of a selective serotonin receptor inhibitor (SSRI) such as escitalopram
(Lexapro), the patient should be monitored for:
agitation, hypersalivation and decreased bowel sounds.
hypothermia, dilated pupils and diaphoresis.
hyperthermia, akathisia and clonus.
lead pipe rigidity, hyporeflexia and tachypnea. - ✔✔ correct answer hyperthermia, akathisia and clonus.
Which statement about naltrexone (Vivitrol) is correct?
The patient may develop tolerance to naltrexone.
Naltrexone should be tapered once desired results are achieved.
The patient should be aware that a possible "rebound" effect may occur after discontinuation.
