Disseminated Intravascular Coagulation (DIC)
Study online at https://quizlet.com/_a1q1co
1. Triggers of Acute 1. Endothelial Cell Damage
DIC 2. Exposure of Tissue Factor
3. Endotoxins with cytokine activation
4. Secretion of proteolytic enzymes
5. Immune complexes
6. Tissue injury
7. Hypoxia
8. Thrombotic disease
9. Platelet activation
2. Trigger: Endothe- Occurs in highly vascularized tissues where there is dam-
lial Cell Damage age to vascular intima
Appropriate arm of Virchow's Triad --> Endothelial cell
damage
Caused by:
1. Adenocarcinoma and other cancers
2. TIA and AMI
3. Thermal Injury
4. Muscle degradation
5. Surgery
3. Trigger: Exposed Also occurs in highly vascularized tissues where there is
Tissue Factor damage to vascular intima
Appropriate arm of Virchow's Triad --> Endothelial cell
damage
Caused by:
1. Hypoxia
2. Hemorrhagic Shock
3. Heat Stroke
4. Vasculitis
5. Malignant Hypertension
4. Trigger: Endotox- Also occurs in highly vascularized tissues where there is
ins with Activa- damage to vascular intima due to endotoxin release
tion of Cytokines
1/5
, Disseminated Intravascular Coagulation (DIC)
Study online at https://quizlet.com/_a1q1co
Appropriate arm of Virchow's Triad --> Endothelial cell
damage
Caused by:
1. Bacterial infections
2. Protozoan infections
3. Fungal infections
4. Viral infections
5. Toxic Shock Syndrome (TSS)
**Most common cause of sepsis-induced DIC**
5. Trigger: Circulat- The circulating immune complexes damage the vascular
ing immune com- intima, cause impeded blood flow (stasis) and alter blood
plexes constituents (platelets, clotting factors)
Appropriate arm of Virchow's Triad --> Endothelial cell
damage, hypercoagulability, and stasis
Caused by:
1. Bacterial and viral infections
2. Anaphylaxis (Type I hypersensitivity)
3. Hemolytic Transfusion Reactions (HTRs)
4. HIT with thrombosis
5. Medications/Drugs
6. Graft rejection
6. Trigger: Tissue Also occurs in highly vascularized tissues where there is
Injury damage to vascular intima
Appropriate arm of Virchow's Triad --> Endothelial cell
damage
Caused by:
1. Abruptio Placentae
2. Amniotic Fluid Embolism
3. Eclampsia, Preeclampsia, HELLP
4. Retained dead fetus or missed abortion
5. Ruptured uterus
2/5
Study online at https://quizlet.com/_a1q1co
1. Triggers of Acute 1. Endothelial Cell Damage
DIC 2. Exposure of Tissue Factor
3. Endotoxins with cytokine activation
4. Secretion of proteolytic enzymes
5. Immune complexes
6. Tissue injury
7. Hypoxia
8. Thrombotic disease
9. Platelet activation
2. Trigger: Endothe- Occurs in highly vascularized tissues where there is dam-
lial Cell Damage age to vascular intima
Appropriate arm of Virchow's Triad --> Endothelial cell
damage
Caused by:
1. Adenocarcinoma and other cancers
2. TIA and AMI
3. Thermal Injury
4. Muscle degradation
5. Surgery
3. Trigger: Exposed Also occurs in highly vascularized tissues where there is
Tissue Factor damage to vascular intima
Appropriate arm of Virchow's Triad --> Endothelial cell
damage
Caused by:
1. Hypoxia
2. Hemorrhagic Shock
3. Heat Stroke
4. Vasculitis
5. Malignant Hypertension
4. Trigger: Endotox- Also occurs in highly vascularized tissues where there is
ins with Activa- damage to vascular intima due to endotoxin release
tion of Cytokines
1/5
, Disseminated Intravascular Coagulation (DIC)
Study online at https://quizlet.com/_a1q1co
Appropriate arm of Virchow's Triad --> Endothelial cell
damage
Caused by:
1. Bacterial infections
2. Protozoan infections
3. Fungal infections
4. Viral infections
5. Toxic Shock Syndrome (TSS)
**Most common cause of sepsis-induced DIC**
5. Trigger: Circulat- The circulating immune complexes damage the vascular
ing immune com- intima, cause impeded blood flow (stasis) and alter blood
plexes constituents (platelets, clotting factors)
Appropriate arm of Virchow's Triad --> Endothelial cell
damage, hypercoagulability, and stasis
Caused by:
1. Bacterial and viral infections
2. Anaphylaxis (Type I hypersensitivity)
3. Hemolytic Transfusion Reactions (HTRs)
4. HIT with thrombosis
5. Medications/Drugs
6. Graft rejection
6. Trigger: Tissue Also occurs in highly vascularized tissues where there is
Injury damage to vascular intima
Appropriate arm of Virchow's Triad --> Endothelial cell
damage
Caused by:
1. Abruptio Placentae
2. Amniotic Fluid Embolism
3. Eclampsia, Preeclampsia, HELLP
4. Retained dead fetus or missed abortion
5. Ruptured uterus
2/5
