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Biochemistry-Angiogenesis: Role of VEGF and Hypoxia

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Institution
Biochemistry
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Biochemistry

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December 7, 2024
Number of pages
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Written in
2024/2025
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Biochemistry

Angiogenesis: Role Of Vegf And Hypoxia




Compiled By Simon Mwangi
Edition: 2024/25

, Science | Biochemistry I of VI pages
1. vasculogenesis
the embryonic formation of endothelial cells from the mesoderm layer precursors to form new blood vessels in

2. vasculogenesis is often paired with
angiogenesis

3. angiogenesis is needed to fully form
the vascular network

4. vasculogenesis gives rise to (2)
the heart and the first primitive vascular plexus inside the embryo and in its surrounding membranes

5. where does the vascular system form in the embryo? (2)
blood islands of the yolk sac
embryo proper

6. angiogenesis
the process by which new blood vessels form from pre-existing vessels that are formed in the early stages of

7. two types of angiogenesis
sprouting angiogenesis
intussusceptive angiogenesis

8. sprouting angiogenesis
tissues that have low nutrient and oxygen supply will produce signals (VEGF-A) that induces endothelial cells
secrete proteases that degrade their basement membranes and allow the endothelial cells to escape their
vessel walls. These cells continue to proliferate and form sprouts connecting neighboring vessels, guided by

9. intussusceptive angiogenesis
also known as splitting angiogenesis is the formation of new vessels by splitting a pre-existing vessel in two

10. example of angiogenesis in women
menstruation, each month for a few days in the lining of the uterus during the menstrual cycle as new blood

11. another example of angiogenesis
would repair

12. The largest of the blood vessels are the (2)
arteries and veins

13. arteries and veins have a tough, thick layer of (2)
connective tissue and many smooth muscle cells

14. The thickness of these layers varies depending upon the (2)
diameter and function of the vessel

15. The interior of the blood vessel consists of


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