NAGELHOUT 6 EXAM QUESTIONS AND ANSWERS
nonionized drugs - ANSWER ________ drugs are soluble in H2O and
therefore are not absorbed via the stomach, cross the blood-brain barrier, and
placenta, whereas, ________ are lipophilic and can penetrate these barriers.
pKa (dissociation constant) - ANSWER the degree of ionization at a particular
site is determined by the ____________ and the pH gradient across the
membrane.
acids - ANSWER proton donors are considered ________, whereas proton
acceptors are called _______.
gastric juice
duodenum
ileum
large intestine
plasma
CSF
urine - ANSWER pH of 1-3
5-6
8
8
7.4
7.3
4-8
gastric juice partial ionization
nonionized drugs - ANSWER ________ drugs are soluble in H2O and
therefore are not absorbed via the stomach, cross the blood-brain barrier, and
placenta, whereas, ________ are lipophilic and can penetrate these barriers.
pKa (dissociation constant) - ANSWER the degree of ionization at a particular
site is determined by the ____________ and the pH gradient across the
membrane.
acids - ANSWER proton donors are considered ________, whereas proton
acceptors are called _______.
gastric juice
duodenum
ileum
large intestine
plasma
CSF
urine - ANSWER pH of 1-3
5-6
8
8
7.4
7.3
4-8
gastric juice partial ionization