NAGELHOUT CHAPTER 7 EXAM QUESTIONS AND
ANSWERS
Q - What is meant by the term MAC or minimum alveolar concentration? -
ANSWER A - It is the alveolar concentration that is needed to produce
anaesthesia (immobility) in 50% of the population in response to surgical
stimulus
Q - The blood/gas solubility coefficient of an anaesthetic represents: -
ANSWER A - The proportion of the anaesthetic that will be soluble in blood,
bind to blood components and will not enter tissues versus the fraction of drug
that will diffuse into tissue
Q - Blood/gas solubility coefficient is an indicator of: - ANSWER A - Speed
of uptake and elimination of an anaesthetic agent
Q - The higher the blood/gas coefficient: - ANSWER A - The slower the lung
and brain uptake, and the slower anesthesia is achieved
Q - Isoflurane's blood/gas coefficient of 1.4:1 represents: - ANSWER A - For
every one molecule of isoflurane, 1.4 times as much stays bound to blood
Q - Agents with a low blood/gas coefficient leave the blood quickly and: -
ANSWER A - Rapidly enter tissues to produce anesthesia quickly
Q - Desflurane's blood/gas coefficient of 0.42 represents: - ANSWER A - For
each desflurane molecule, only 0.42 stays bound to blood
, Q - Nitrous oxide has a faster rate of rise compared to Desflurane related to: -
ANSWER A - The concentration effect (N2O is given at 70%, Desflurane is
given at 3-9%)
Q - What is the ventilation effect? - ANSWER A - The faster and more deeply
a patient breathes, the faster they achieve anesthesia or emerge
Q - Which agents are more effected by ventilation/perfusion deficits or poor
lung function (r/t blood/gas solubility)? - ANSWER A - Low blood/gas
soluble agents are more effected by V/Q mismatches
Q - What is overpresuring? - ANSWER A - Using a higher concentration of
drug than necessary for maintenance to quicken initial drug uptake
Q - Sevoflurane MAC? - ANSWER A - 2% MAC
Q - The blood gas partition coefficient of Sevoflurane? - ANSWER A - 0.6
Q - What is the induction dose of Sevoflurane? - ANSWER A - 4-8%
Q - What is the maintenance dose of Sevoflurane? - ANSWER A - 1-4%
Q - What is the MAC of Isoflurane? - ANSWER A - 1.15% MAC
Q - What is the blood/gas coefficient of Isoflurane? - ANSWER A - 1.4
Q - What is the maintenance dose of Isoflurane? - ANSWER A - 0.5-2%
ANSWERS
Q - What is meant by the term MAC or minimum alveolar concentration? -
ANSWER A - It is the alveolar concentration that is needed to produce
anaesthesia (immobility) in 50% of the population in response to surgical
stimulus
Q - The blood/gas solubility coefficient of an anaesthetic represents: -
ANSWER A - The proportion of the anaesthetic that will be soluble in blood,
bind to blood components and will not enter tissues versus the fraction of drug
that will diffuse into tissue
Q - Blood/gas solubility coefficient is an indicator of: - ANSWER A - Speed
of uptake and elimination of an anaesthetic agent
Q - The higher the blood/gas coefficient: - ANSWER A - The slower the lung
and brain uptake, and the slower anesthesia is achieved
Q - Isoflurane's blood/gas coefficient of 1.4:1 represents: - ANSWER A - For
every one molecule of isoflurane, 1.4 times as much stays bound to blood
Q - Agents with a low blood/gas coefficient leave the blood quickly and: -
ANSWER A - Rapidly enter tissues to produce anesthesia quickly
Q - Desflurane's blood/gas coefficient of 0.42 represents: - ANSWER A - For
each desflurane molecule, only 0.42 stays bound to blood
, Q - Nitrous oxide has a faster rate of rise compared to Desflurane related to: -
ANSWER A - The concentration effect (N2O is given at 70%, Desflurane is
given at 3-9%)
Q - What is the ventilation effect? - ANSWER A - The faster and more deeply
a patient breathes, the faster they achieve anesthesia or emerge
Q - Which agents are more effected by ventilation/perfusion deficits or poor
lung function (r/t blood/gas solubility)? - ANSWER A - Low blood/gas
soluble agents are more effected by V/Q mismatches
Q - What is overpresuring? - ANSWER A - Using a higher concentration of
drug than necessary for maintenance to quicken initial drug uptake
Q - Sevoflurane MAC? - ANSWER A - 2% MAC
Q - The blood gas partition coefficient of Sevoflurane? - ANSWER A - 0.6
Q - What is the induction dose of Sevoflurane? - ANSWER A - 4-8%
Q - What is the maintenance dose of Sevoflurane? - ANSWER A - 1-4%
Q - What is the MAC of Isoflurane? - ANSWER A - 1.15% MAC
Q - What is the blood/gas coefficient of Isoflurane? - ANSWER A - 1.4
Q - What is the maintenance dose of Isoflurane? - ANSWER A - 0.5-2%
