©FYNDLAY EXAM SOLUTIONS 2024/2025
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Advanced Biochemistry Final Exam
Questions And Answers (Guaranteed A+)
What is the limiting substance in the biosynthesis of purines?
A. ribose-5-phosphate
B. 5-phosphoribosyl-β amine
C. formylglycinamidine ribonucleotide
D. 5-phosphoribosyl-α-pyrophosphate (PRPP)
E. α-D-ribose-5-phosphate - answer✔D
The coenzyme for two single carbon additions in purine biosynthesis is:
A. THF
B. biotin
C. SAM
D. TPP
E. none are true - answer✔A
What is the common product of purine catabolism?
A. xanthine
B. uric acid
C. inosine
D. hypoxanthine
E. xanthosine - answer✔B
Thymidylate synthase synthesizes dTMP from __ by __ , utilizing the coenzyme __.
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, ©FYNDLAY EXAM SOLUTIONS 2024/2025
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A. dCTP; carboxylation; biotin
B. dUMP; methylation; THF
C. dCMP; methylation; THF
D. dGMP; phosphorylation; ATP
E. dUMP; phosphorylation; ATP - answer✔B
Which is a six-membered heterocyclic aromatic ring?
A. pyrimidine
B. purine
C. anose
D. sugar portion of DNA
E. ribonucleotide - answer✔A
Which of the following statements regarding the structure of DNA is correct?
A. the two strands are parallel
B. the two strands are held together by intrachain hydrogen bonds
C. the two strands have complementary base pairing
D. the ;hydrogen bonding that holds the helix together is always between two purines or
between two pyrimidines
E. the ratio of adenine to guanine is the same in all organisms - answer✔C
The convention in all notations of nucleic acid structure is to read the polynucleotide chain
from the __ of the polymer to the __.
A. poly U head; poly A tail
B. 3' end; 5' tail
C. 5' end; 3' end
D. poly-p head; 5' head
E. none are true - answer✔C
In eukaryotic cells, a class of __- and __-rich proteins called __ interact ionically with the anionic
phosphate groups in the DNA backbone to form __.
2|Page
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A. lysine; leucine; prions; ribosomes
B. arginine; lysine; histones; nucleosomes
C. arginine; alanine; histones; nucleosomes
D. arginine; lysine; prions; ribosomes
E. none are true - answer✔B
Eukaryotic mRNAs are synthesized in the nucleus, are called __, and contain noncoding regions
called __ because they intervene between coding regions called __.
A. poly A RNAs; noncodons; codons
B. poly A RNAs; intervening sequences; codons
C. heterogeneous nuclear RNAs; intervening sequences (introns); codons
D. heterogeneous nuclear RNAs; intervening sequenes (introns); exons
E. none of the above - answer✔D
Enzymes that catalyze the unwinding of DNA double helices are:
A. topoisomerases
B. helicases
C. ligases
D. gyrases
E. polymerases - answer✔B
SSBs are:
A. substrates for DNA ligases
B. supercoil stabilizing bodies
C. single-stranded bodies called Okazaki fragments
D. single-stranded DNA binding proteins that prevent re-annealing
E. nucleases that hydrolyze single-stranded RNA primers - answer✔D
Which of the following is NOT true regarding E. coli replication on the lagging strand?
A. primarily carried out by DNA polymerase I
3|Page
ALL RIGHTS RESERVED.
Advanced Biochemistry Final Exam
Questions And Answers (Guaranteed A+)
What is the limiting substance in the biosynthesis of purines?
A. ribose-5-phosphate
B. 5-phosphoribosyl-β amine
C. formylglycinamidine ribonucleotide
D. 5-phosphoribosyl-α-pyrophosphate (PRPP)
E. α-D-ribose-5-phosphate - answer✔D
The coenzyme for two single carbon additions in purine biosynthesis is:
A. THF
B. biotin
C. SAM
D. TPP
E. none are true - answer✔A
What is the common product of purine catabolism?
A. xanthine
B. uric acid
C. inosine
D. hypoxanthine
E. xanthosine - answer✔B
Thymidylate synthase synthesizes dTMP from __ by __ , utilizing the coenzyme __.
1|Page
, ©FYNDLAY EXAM SOLUTIONS 2024/2025
ALL RIGHTS RESERVED.
A. dCTP; carboxylation; biotin
B. dUMP; methylation; THF
C. dCMP; methylation; THF
D. dGMP; phosphorylation; ATP
E. dUMP; phosphorylation; ATP - answer✔B
Which is a six-membered heterocyclic aromatic ring?
A. pyrimidine
B. purine
C. anose
D. sugar portion of DNA
E. ribonucleotide - answer✔A
Which of the following statements regarding the structure of DNA is correct?
A. the two strands are parallel
B. the two strands are held together by intrachain hydrogen bonds
C. the two strands have complementary base pairing
D. the ;hydrogen bonding that holds the helix together is always between two purines or
between two pyrimidines
E. the ratio of adenine to guanine is the same in all organisms - answer✔C
The convention in all notations of nucleic acid structure is to read the polynucleotide chain
from the __ of the polymer to the __.
A. poly U head; poly A tail
B. 3' end; 5' tail
C. 5' end; 3' end
D. poly-p head; 5' head
E. none are true - answer✔C
In eukaryotic cells, a class of __- and __-rich proteins called __ interact ionically with the anionic
phosphate groups in the DNA backbone to form __.
2|Page
, ©FYNDLAY EXAM SOLUTIONS 2024/2025
ALL RIGHTS RESERVED.
A. lysine; leucine; prions; ribosomes
B. arginine; lysine; histones; nucleosomes
C. arginine; alanine; histones; nucleosomes
D. arginine; lysine; prions; ribosomes
E. none are true - answer✔B
Eukaryotic mRNAs are synthesized in the nucleus, are called __, and contain noncoding regions
called __ because they intervene between coding regions called __.
A. poly A RNAs; noncodons; codons
B. poly A RNAs; intervening sequences; codons
C. heterogeneous nuclear RNAs; intervening sequences (introns); codons
D. heterogeneous nuclear RNAs; intervening sequenes (introns); exons
E. none of the above - answer✔D
Enzymes that catalyze the unwinding of DNA double helices are:
A. topoisomerases
B. helicases
C. ligases
D. gyrases
E. polymerases - answer✔B
SSBs are:
A. substrates for DNA ligases
B. supercoil stabilizing bodies
C. single-stranded bodies called Okazaki fragments
D. single-stranded DNA binding proteins that prevent re-annealing
E. nucleases that hydrolyze single-stranded RNA primers - answer✔D
Which of the following is NOT true regarding E. coli replication on the lagging strand?
A. primarily carried out by DNA polymerase I
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