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Doxorubicin - ✔✔Cardiotoxic
TISSUE VESICANT
Baseline MUGA and total dose (CONCERN at 550 mg/m2)
URINE=RED
IF EXTRAVASATION OCCURS= cool/ice + Totect
Idamycin - ✔✔Cardiotoxic (cardiomyopathy)
Bleomycin - ✔✔AVOID oxygen supplementation
Methotrexate - ✔✔*Leukovorin decreases cytotoxicity*
Pemetrexed - ✔✔Vitamin B12 & folic acid supplements to decrease toxicity
Fludarabine - ✔✔Immunosuppression
Thioguanine - ✔✔Bone Marrow Suppression
Stomatitis/Mucositis
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, 5-FU - ✔✔*Stomatitis
Bone marrow depression
*Diarrhea
Mucositis
Capeticibine - ✔✔***Pro-drug that converts 5FU in liver
Stomatitis & mucositis
Palmar-plantar erythrodysthesias (hand foot syndrome)
Cytarabine or Cytosine Arabinoside - ✔✔Cerebellar neurotoxicity
Gemcitabine - ✔✔Radiosensitizer DO NOT GIVE W/ RADIATION, except
at very low doses
Carmustine - ✔✔***Solvent is alcohol
Alcohol sensivity is an issue
Mix ONLY in 0.9% NaCl
Carboplatin - ✔✔Dose by CALVERT formula
Allergic reaction increased from 1-27% in pts receiving >6-7 courses
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