©Themoon EXAM SOLUTIONS
25/11/2024 09:27AM
Biochem 301 Exam 1 and Answers
2nd law of thermodynamics - Answers✓✓-nature tends to become more distorted
-entropy does not decrease in a closed system (entropy will stay the same or increase)
What is the relationship between deltaG and K (equilibrium constant)? - Answers✓✓As K
increases, deltaG decreases.
Relationship between K and Q? - Answers✓✓Q < K --> reactions proceeds forwards
Q = K --> equilibrium
Q > K --> reactions proceeds backwards
Other amino acids - Answers✓✓-4-hydroxyproline: found in collagen
-ornithine and citrulline are metabolism intermediates
Adding positive charges to amino acid solution will... - Answers✓✓lower the pKa because the
amino acid will be more likely to give a proton
Adding negative charges to amino acid solution will... - Answers✓✓raise the pKa because the
amino acid will be more likely to keep its proton to avoid resulting in negative-negative
interactions
Amino acids are counted from... - Answers✓✓the N-terminal end to the C-terminal end
Structure of peptide bond - Answers✓✓-planar
, ©Themoon EXAM SOLUTIONS
25/11/2024 09:27AM
-normally trans
Rotation of bonds - Answers✓✓-C-N bond cannot rotate
-alpha-C's can rotate about their bonds
Proline unique conformation - Answers✓✓All amino acids are in the trans form except proline,
which may have some in the cis form due to the steric hindrances caused by the ring
Disulfide bonds intracellularly and extracellularly - Answers✓✓-Disulfide bonds don't typically
exist intracellularly
-Exist outside the cell to maintain protein structure in the harsh external environment to
maintain protein structure
-Extracellular environment is oxidizing, resulting in disulfide bonds
Alpha helix structure - Answers✓✓-backbone atoms follow helical pathway
-held together by hydrogen bonds between every fourth carbon (i+3)
Beta sheet structure - Answers✓✓-formed using carbon backbone
-can be parallel or anti-parallel
Difference between alpha helix and beta sheet - Answers✓✓-alpha helix is formed from a
single chain of amino acids
-beta sheet is formed from several short contiguous amino acid chains placed side by side
Anti-parallel vs. parallel beta sheet - Answers✓✓Must have longer loops for parallel structure
than anti-parallel structure
25/11/2024 09:27AM
Biochem 301 Exam 1 and Answers
2nd law of thermodynamics - Answers✓✓-nature tends to become more distorted
-entropy does not decrease in a closed system (entropy will stay the same or increase)
What is the relationship between deltaG and K (equilibrium constant)? - Answers✓✓As K
increases, deltaG decreases.
Relationship between K and Q? - Answers✓✓Q < K --> reactions proceeds forwards
Q = K --> equilibrium
Q > K --> reactions proceeds backwards
Other amino acids - Answers✓✓-4-hydroxyproline: found in collagen
-ornithine and citrulline are metabolism intermediates
Adding positive charges to amino acid solution will... - Answers✓✓lower the pKa because the
amino acid will be more likely to give a proton
Adding negative charges to amino acid solution will... - Answers✓✓raise the pKa because the
amino acid will be more likely to keep its proton to avoid resulting in negative-negative
interactions
Amino acids are counted from... - Answers✓✓the N-terminal end to the C-terminal end
Structure of peptide bond - Answers✓✓-planar
, ©Themoon EXAM SOLUTIONS
25/11/2024 09:27AM
-normally trans
Rotation of bonds - Answers✓✓-C-N bond cannot rotate
-alpha-C's can rotate about their bonds
Proline unique conformation - Answers✓✓All amino acids are in the trans form except proline,
which may have some in the cis form due to the steric hindrances caused by the ring
Disulfide bonds intracellularly and extracellularly - Answers✓✓-Disulfide bonds don't typically
exist intracellularly
-Exist outside the cell to maintain protein structure in the harsh external environment to
maintain protein structure
-Extracellular environment is oxidizing, resulting in disulfide bonds
Alpha helix structure - Answers✓✓-backbone atoms follow helical pathway
-held together by hydrogen bonds between every fourth carbon (i+3)
Beta sheet structure - Answers✓✓-formed using carbon backbone
-can be parallel or anti-parallel
Difference between alpha helix and beta sheet - Answers✓✓-alpha helix is formed from a
single chain of amino acids
-beta sheet is formed from several short contiguous amino acid chains placed side by side
Anti-parallel vs. parallel beta sheet - Answers✓✓Must have longer loops for parallel structure
than anti-parallel structure
