Hema Boards Review Pt. 2
blood picture mimics chronic myelogenous leukemia
(CML) benign, specific response to specific agent or
stimulus WBC count can increase to 50-100 x
10^9/L
INCREASED LAP score
shift to the left with toxic changes to neutrophils correct answers
NEUTROPHILIC LEUKEMOID REACTION
presence of immature leukocytes and immature erythrocytes in the
blood
occurs in marrow replacement disorders such as MYELOFIBROSIS correct
answers leukoerythroblastic reaction
morphologically normal, pathologically abnormal because of enzyme
deficiency that results in an ability to degranulate which causes inhibited
bactericidal function
- phagocytic defect of neutrophil correct answers Chronic
granulomatous disease (CGD)
treatment for chronic granulomatous disease? correct answers granulocyte
concentrate both morphologically and functionally abnormal leukocytes
WBCs are unable to degranulate and kill invading bacteria
Leukocytes have gigantic granules that are PEROXIDASE positive correct
answers Chediak-Higashi syndrome
5 or more lobes in the neutrophil, associated with megaloblastic
anemia correct answers hypersegmentation
nucleus is hyperclumped and does not mature past the two-
fold stage nucleus has a dumbell or peanut-shape; "PINCE-
NEZ" appearance
morphologically abnormal but functionally normal correct answers
PELGER-HUET ANOMALY
granulocytes whose nucleus is segmented only once, taking the form of
"two very distinct segments connected by very thin filaments correct
answers heterozygous pelger-huet anomaly
characterized by granulocytes with round or oval nuclei (no
segmentation)
may be accompanied by impaired cognitive development, skeletal
abnormalities, and heart defects correct answers homozygous pelger-huet
anomaly
large crystalline, dohle-like inclusions in the cytoplasm of neutrophils on
Wright's stain; gray blue spindle (CIGAR SHAPED)
, GIANT PLATELETS, thrombocytopenia, clinical bleeding correct answers May-
Hegglin anomaly
large AZUROPHILIC granules appear in the cytoplasm of all or only one
cell line granules contain degraded mucopolysaccharides due to an
enzyme defect correct answers ALDER-REILLY ANOMALY
most common lipid storage disorder - deficiency in glucocerebrosidase
causes glucocerebroside to accumulate in the macrophages of the bone
marrow, spleen, and liver
crumpled tissue paper appearance of macrophage correct answers
GAUCHER DISEASE
deficiency in sphingomyelinase causes sphingomyelin to
accumulate in the macrophages of the bone marrow, spleen, and
liver
FOAMY appearance of macrophages (foam cells) correct answers
NIEMANN-PICK DISEASE
caused by Epstein-Barr virus
(CD21) Targets: B-CELLS
REACTIVE T-LYMPHOCYTES are
present attacking infected B-
cells
POSITIVE heterophile antibody
test correct answers
INFECTIOUS MONONUCLEOSIS
most common transmitted infection from mother
to fetus NEGATIVE heterophile antibody test
No reactive lymphocytes correct answers
CYTOMEGALOVIRUS
associated with adenovirus and coxsackie A
virus contagious disease mostly affecting
young children
lymphocytosis with no reactive lymphocytes
correct answers infectiouslymphocytosis
FAB CLASSIFICATION correct answers french-american-british
classification DEFINES ACUTE LEUKEMIA AS > 30% BONE MARROW
BLASTS
- CELLULAR MORPHOLOGY
- CYTOCHEMICAL STAIN RESULTS
WHO CLASSIFICATION correct answers THE STANDARD FOR
DIAGNOSIS DEFINES ACUTE LEUKEMIA AS > 20% BONE MARROW
BLASTS
most common leukemia in adults? correct answers ACUTE MYELOID
blood picture mimics chronic myelogenous leukemia
(CML) benign, specific response to specific agent or
stimulus WBC count can increase to 50-100 x
10^9/L
INCREASED LAP score
shift to the left with toxic changes to neutrophils correct answers
NEUTROPHILIC LEUKEMOID REACTION
presence of immature leukocytes and immature erythrocytes in the
blood
occurs in marrow replacement disorders such as MYELOFIBROSIS correct
answers leukoerythroblastic reaction
morphologically normal, pathologically abnormal because of enzyme
deficiency that results in an ability to degranulate which causes inhibited
bactericidal function
- phagocytic defect of neutrophil correct answers Chronic
granulomatous disease (CGD)
treatment for chronic granulomatous disease? correct answers granulocyte
concentrate both morphologically and functionally abnormal leukocytes
WBCs are unable to degranulate and kill invading bacteria
Leukocytes have gigantic granules that are PEROXIDASE positive correct
answers Chediak-Higashi syndrome
5 or more lobes in the neutrophil, associated with megaloblastic
anemia correct answers hypersegmentation
nucleus is hyperclumped and does not mature past the two-
fold stage nucleus has a dumbell or peanut-shape; "PINCE-
NEZ" appearance
morphologically abnormal but functionally normal correct answers
PELGER-HUET ANOMALY
granulocytes whose nucleus is segmented only once, taking the form of
"two very distinct segments connected by very thin filaments correct
answers heterozygous pelger-huet anomaly
characterized by granulocytes with round or oval nuclei (no
segmentation)
may be accompanied by impaired cognitive development, skeletal
abnormalities, and heart defects correct answers homozygous pelger-huet
anomaly
large crystalline, dohle-like inclusions in the cytoplasm of neutrophils on
Wright's stain; gray blue spindle (CIGAR SHAPED)
, GIANT PLATELETS, thrombocytopenia, clinical bleeding correct answers May-
Hegglin anomaly
large AZUROPHILIC granules appear in the cytoplasm of all or only one
cell line granules contain degraded mucopolysaccharides due to an
enzyme defect correct answers ALDER-REILLY ANOMALY
most common lipid storage disorder - deficiency in glucocerebrosidase
causes glucocerebroside to accumulate in the macrophages of the bone
marrow, spleen, and liver
crumpled tissue paper appearance of macrophage correct answers
GAUCHER DISEASE
deficiency in sphingomyelinase causes sphingomyelin to
accumulate in the macrophages of the bone marrow, spleen, and
liver
FOAMY appearance of macrophages (foam cells) correct answers
NIEMANN-PICK DISEASE
caused by Epstein-Barr virus
(CD21) Targets: B-CELLS
REACTIVE T-LYMPHOCYTES are
present attacking infected B-
cells
POSITIVE heterophile antibody
test correct answers
INFECTIOUS MONONUCLEOSIS
most common transmitted infection from mother
to fetus NEGATIVE heterophile antibody test
No reactive lymphocytes correct answers
CYTOMEGALOVIRUS
associated with adenovirus and coxsackie A
virus contagious disease mostly affecting
young children
lymphocytosis with no reactive lymphocytes
correct answers infectiouslymphocytosis
FAB CLASSIFICATION correct answers french-american-british
classification DEFINES ACUTE LEUKEMIA AS > 30% BONE MARROW
BLASTS
- CELLULAR MORPHOLOGY
- CYTOCHEMICAL STAIN RESULTS
WHO CLASSIFICATION correct answers THE STANDARD FOR
DIAGNOSIS DEFINES ACUTE LEUKEMIA AS > 20% BONE MARROW
BLASTS
most common leukemia in adults? correct answers ACUTE MYELOID
