PHMY 610 RESPIRATORY EXAM 3
LATEST VERSION
respiratory syncytial virus (RSV) is:
DNA or RNA?
segmented or non-segmented?
enveloped or non-enveloped?
RNA (ssRNA), non-segmented, enveloped
what is the most common syndrome with RSV
common cold
what can RSV cause in younger children
bronchiolitis and/or pneumonia
when is the peak RSV season
late fall-winter
what are risk factors for poor outcomes with RSV
premature infants, < 2 years old with CLD/heart disease, IC children, children
with NM disorders, < 8 weeks of age = most severe
what are two important proteins on RSV
attachment glycoprotein (G) and fusion glycoprotein (F)
what is attachment glycoprotein of RSV important for
attaching to epithelial cells - also induces neutralizing antibody responses and
can induce IFN=gamma producing T cells
T/F: nucleoprotein and M2-1 of RSV are conserved internal protein and can
induce IFN-gamma producing CD8+ T cells
true
which RSV protein is required for cell entry
, fusion glycoprotein
which protein is a highly conserved antigen across all known RSV subtypes,
induces neutralizing antibody responses, and can induce IFN gamma producing
T cells
fusion glycoprotein
what is pre fusion glycoprotein required for
binding/fission
what are ways to diagnose RSV
antigen/antibody testing, PCR (best option)
T/F: antigen/antibody testing for RSV is sensitive in children and adults
false, not sensitive in adults
is PCR very sensitive in really young children
not really
is viral culture done with RSV
rarely ever
do adults typically need RSV diagnosis
rarely ever
is there an RSV immunoglobulin option for treatment
one exists, but is not readily available or widely used
what is main target protein for drug therapy with RSV
fusion glycoprotein (pre-F)
who is the RSV vaccine for
adults > 60 and pregnancy 32-36 weeks gestation
what family is metapneumovirus in
paroxymovirus
LATEST VERSION
respiratory syncytial virus (RSV) is:
DNA or RNA?
segmented or non-segmented?
enveloped or non-enveloped?
RNA (ssRNA), non-segmented, enveloped
what is the most common syndrome with RSV
common cold
what can RSV cause in younger children
bronchiolitis and/or pneumonia
when is the peak RSV season
late fall-winter
what are risk factors for poor outcomes with RSV
premature infants, < 2 years old with CLD/heart disease, IC children, children
with NM disorders, < 8 weeks of age = most severe
what are two important proteins on RSV
attachment glycoprotein (G) and fusion glycoprotein (F)
what is attachment glycoprotein of RSV important for
attaching to epithelial cells - also induces neutralizing antibody responses and
can induce IFN=gamma producing T cells
T/F: nucleoprotein and M2-1 of RSV are conserved internal protein and can
induce IFN-gamma producing CD8+ T cells
true
which RSV protein is required for cell entry
, fusion glycoprotein
which protein is a highly conserved antigen across all known RSV subtypes,
induces neutralizing antibody responses, and can induce IFN gamma producing
T cells
fusion glycoprotein
what is pre fusion glycoprotein required for
binding/fission
what are ways to diagnose RSV
antigen/antibody testing, PCR (best option)
T/F: antigen/antibody testing for RSV is sensitive in children and adults
false, not sensitive in adults
is PCR very sensitive in really young children
not really
is viral culture done with RSV
rarely ever
do adults typically need RSV diagnosis
rarely ever
is there an RSV immunoglobulin option for treatment
one exists, but is not readily available or widely used
what is main target protein for drug therapy with RSV
fusion glycoprotein (pre-F)
who is the RSV vaccine for
adults > 60 and pregnancy 32-36 weeks gestation
what family is metapneumovirus in
paroxymovirus
