PHCY 611 Exam 1 Smitslet
Questions and Answers
Denning [Date] [Course title]
,What does the acronym 3PHARMDWISED stand for? - Correct Answers: PK/PD/PGx
How
ADRs/Allergies
Regimen
Monitoring
Duration
Warnings/precautions/contraindications
Interactions
Special Populations
Education/counseling
Determinants of health
SSRI MOA - Correct Answers: inhibit SERT to block serotonin reuptake
SNRI MOA - Correct Answers: inhibit SERT and NET to block serotonin and norepinephrine reuptake,
respectively
TCA MOA - Correct Answers: same as SNRI's (inhibit reuptake of 5-HT and NE by SERT and NET)
mirtazapine MOA - Correct Answers: alpha-2 adrenergic antagonist (which increases monoamine
release)
bupropion MOA - Correct Answers: not fully elucidated, but it does inhibit dopamine reuptake and
weakly inhibits NE reuptake
Common non-antidepressants that can lead to serotonin syndrome - Correct Answers: -triptan meds,
linezolid, tramadol, SAM-e, St. John's wort, dextromethorphan
For each of the following, which CYP enzyme metabolizes each drug?
, a) quetiapine
b) aripiprazole
c) olanzapine/clozapine
d) brexipiprazole
e) risperidone
f) haloperidol - Correct Answers: a) CYP3A4
b) CYP3A4, CYP2D6
c) CYP1A2
d) CYP2D6, CYP3A4
e) CYP2D6
f) CYP2D6, CYP3A4
Which of the following are adverse effects associated with SSRIs and/or SNRIs (select all that apply)?
a) Discontinuation syndrome
b) GI upset
c) renal toxicity
d) potential for suicidal thoughts/behaviors - Correct Answers: a), b), and d)
Which of the following (select all that apply) are symptoms of serotonin syndrome?
a) tremor
b) hypoactivity
c) hyperreflexia
d) hypothermia - Correct Answers: a) and c)
The second generation antipsychotic agents block D-1 dopamine receptors stereoselectively as their
primary mechanism of action (T/F) - Correct Answers: F
Questions and Answers
Denning [Date] [Course title]
,What does the acronym 3PHARMDWISED stand for? - Correct Answers: PK/PD/PGx
How
ADRs/Allergies
Regimen
Monitoring
Duration
Warnings/precautions/contraindications
Interactions
Special Populations
Education/counseling
Determinants of health
SSRI MOA - Correct Answers: inhibit SERT to block serotonin reuptake
SNRI MOA - Correct Answers: inhibit SERT and NET to block serotonin and norepinephrine reuptake,
respectively
TCA MOA - Correct Answers: same as SNRI's (inhibit reuptake of 5-HT and NE by SERT and NET)
mirtazapine MOA - Correct Answers: alpha-2 adrenergic antagonist (which increases monoamine
release)
bupropion MOA - Correct Answers: not fully elucidated, but it does inhibit dopamine reuptake and
weakly inhibits NE reuptake
Common non-antidepressants that can lead to serotonin syndrome - Correct Answers: -triptan meds,
linezolid, tramadol, SAM-e, St. John's wort, dextromethorphan
For each of the following, which CYP enzyme metabolizes each drug?
, a) quetiapine
b) aripiprazole
c) olanzapine/clozapine
d) brexipiprazole
e) risperidone
f) haloperidol - Correct Answers: a) CYP3A4
b) CYP3A4, CYP2D6
c) CYP1A2
d) CYP2D6, CYP3A4
e) CYP2D6
f) CYP2D6, CYP3A4
Which of the following are adverse effects associated with SSRIs and/or SNRIs (select all that apply)?
a) Discontinuation syndrome
b) GI upset
c) renal toxicity
d) potential for suicidal thoughts/behaviors - Correct Answers: a), b), and d)
Which of the following (select all that apply) are symptoms of serotonin syndrome?
a) tremor
b) hypoactivity
c) hyperreflexia
d) hypothermia - Correct Answers: a) and c)
The second generation antipsychotic agents block D-1 dopamine receptors stereoselectively as their
primary mechanism of action (T/F) - Correct Answers: F
