©BRIGHTSTARS EXAM SOLUTIONS
10/22/2024 12:14 PM
Pharmacology chapter 17 (Final Exam)
Questions And Answers 100% Pass.
Antagonists - answer✔what type of drugs only have affinity and lack intrinsic activity?
agonist - answer✔what type of drugs have both affinity and intrinsic activity
adrenergic receptors - answer✔activation of what receptors causes responses That are Identical
to When the SNS is Stimulated with Endogenous Molecules?
-receptor binding (direct process)
-promotion of NE release (indirect process)
-blockade of NE reuptake (indirect process)
-inhibition of NE inactivation (indirect process - answer✔what are the 4 mechanisms of
adrenergic receptor activation?
sympathetic nerve terminals - answer✔Norepinephrine is released when drug acts on ____
amphetamines - answer✔what drugs are an example of promotion of NE release?
TSAs - answer✔what drugs are an example of blockade of NE reuptake?
MAO inhibitors and COMT inhibitors - answer✔what drugs are an example of inhibition of NE
inactivation?
MAO and COMT - answer✔what two enzymes are found in the liver and intestine and inactivate
norepinephrine?
catecholamines and noncatecholamines - answer✔what are the two chemical classes of
adrenergic agonists?
catecholamines - answer✔which adrenergic agonist class cannot be used orally (because they
will become inactivated prior to reaching the CNS d/t MAO and COMT), have a brief duration
, ©BRIGHTSTARS EXAM SOLUTIONS
10/22/2024 12:14 PM
of action (Need to be given frequently or via continuous infusion because of rapid inactivation),
and cannot cross the BBB (because they are water soluble)?
Nonchatecholamines - answer✔which adrenergic agonist class can be administered orally
(because they are very slowly metabolized by MAO, and COMT doesn't effect them), have a
much longer half life, and more able to cross the BBB (because they are lipid soluble)?
receptor selectivity - answer✔•These Medications Differ Widely With Respect to the Receptors
They Can Activate
•High Variability Exists in Receptor Selectivity Among the Adrenergic Agonists
•Note: Ability of a Drug to Selectively Activate Certain Receptors and Not Others is Dependent
on Dosage:
-Low Dose = Maximal Selectivity
-High Dose = Decline in Selectivity
alpha 1 - answer✔which receptor site, when stimulated causes mydriasis and vasoconstriction
(which causes increased BP)?
Alpha 2 - answer✔which receptor site, when activated, works in the CNS to reduce
norepinephrine outflow to the heart and blood vessels and relieves severe pain?
relaxation - answer✔at GI smooth muscle, Alpha 1 receptors cause ____ of muscle
blood vessels, eye, bladder, prostate, and uterus - answer✔alpha 1 receptors produce contraction
of smooth muscle in which five areas?
glycogenolysis - answer✔what occurs in the liver when alpha 1 receptors are stimulated?
increased secretions - answer✔what occurs at the salivary glands when alpha 1 receptors are
stimulated?
-Hemostasis- d/t vasoconstriction
-Nasal Decongestion- d/t alpha 1 vasoconstriction
-Adjunct to Local Anesthesia- delays systemic absorption and reduced blood flow to site
-Elevation of Blood Pressure
-Mydriasis (only use not based on vasoconstriction)- helps with eye exams - answer✔what are
the five therapeutic applications of alpha 1 activation?
-Hypertensive
10/22/2024 12:14 PM
Pharmacology chapter 17 (Final Exam)
Questions And Answers 100% Pass.
Antagonists - answer✔what type of drugs only have affinity and lack intrinsic activity?
agonist - answer✔what type of drugs have both affinity and intrinsic activity
adrenergic receptors - answer✔activation of what receptors causes responses That are Identical
to When the SNS is Stimulated with Endogenous Molecules?
-receptor binding (direct process)
-promotion of NE release (indirect process)
-blockade of NE reuptake (indirect process)
-inhibition of NE inactivation (indirect process - answer✔what are the 4 mechanisms of
adrenergic receptor activation?
sympathetic nerve terminals - answer✔Norepinephrine is released when drug acts on ____
amphetamines - answer✔what drugs are an example of promotion of NE release?
TSAs - answer✔what drugs are an example of blockade of NE reuptake?
MAO inhibitors and COMT inhibitors - answer✔what drugs are an example of inhibition of NE
inactivation?
MAO and COMT - answer✔what two enzymes are found in the liver and intestine and inactivate
norepinephrine?
catecholamines and noncatecholamines - answer✔what are the two chemical classes of
adrenergic agonists?
catecholamines - answer✔which adrenergic agonist class cannot be used orally (because they
will become inactivated prior to reaching the CNS d/t MAO and COMT), have a brief duration
, ©BRIGHTSTARS EXAM SOLUTIONS
10/22/2024 12:14 PM
of action (Need to be given frequently or via continuous infusion because of rapid inactivation),
and cannot cross the BBB (because they are water soluble)?
Nonchatecholamines - answer✔which adrenergic agonist class can be administered orally
(because they are very slowly metabolized by MAO, and COMT doesn't effect them), have a
much longer half life, and more able to cross the BBB (because they are lipid soluble)?
receptor selectivity - answer✔•These Medications Differ Widely With Respect to the Receptors
They Can Activate
•High Variability Exists in Receptor Selectivity Among the Adrenergic Agonists
•Note: Ability of a Drug to Selectively Activate Certain Receptors and Not Others is Dependent
on Dosage:
-Low Dose = Maximal Selectivity
-High Dose = Decline in Selectivity
alpha 1 - answer✔which receptor site, when stimulated causes mydriasis and vasoconstriction
(which causes increased BP)?
Alpha 2 - answer✔which receptor site, when activated, works in the CNS to reduce
norepinephrine outflow to the heart and blood vessels and relieves severe pain?
relaxation - answer✔at GI smooth muscle, Alpha 1 receptors cause ____ of muscle
blood vessels, eye, bladder, prostate, and uterus - answer✔alpha 1 receptors produce contraction
of smooth muscle in which five areas?
glycogenolysis - answer✔what occurs in the liver when alpha 1 receptors are stimulated?
increased secretions - answer✔what occurs at the salivary glands when alpha 1 receptors are
stimulated?
-Hemostasis- d/t vasoconstriction
-Nasal Decongestion- d/t alpha 1 vasoconstriction
-Adjunct to Local Anesthesia- delays systemic absorption and reduced blood flow to site
-Elevation of Blood Pressure
-Mydriasis (only use not based on vasoconstriction)- helps with eye exams - answer✔what are
the five therapeutic applications of alpha 1 activation?
-Hypertensive
