Chamberlain NR 565 - Advanced
Pharmacology Midterm (Complete
Solutions) | Latest Q&A
1. A patient with a confirmed MRSA infection has been prescribed vancomycin. What is an
important nursing consideration when administering this medication?
Monitor trough levels to prevent toxicity.
2. A nurse is administering gentamicin to a patient. Which assessment is crucial to monitor for
toxicity?
Hearing and renal function, as gentamicin can cause ototoxicity and nephrotoxicity.
3. Which antibiotic is associated with a high risk of tendon rupture, especially in older adults?
Fluoroquinolones
4. A patient has been prescribed isoniazid for latent tuberculosis. The nurse should recommend
which supplement to prevent neuropathy?
Vitamin B6 (pyridoxine)
5. A nurse is educating a patient about metronidazole for a bacterial infection. What should the
nurse advise regarding alcohol consumption?
Avoid alcohol, as it may cause a disulfiram-like reaction.
1
,6. For patients with a known deficiency in G6PD, which class of drugs should be avoided due to
the risk of hemolysis?
Sulfonamides
7. A patient is prescribed clopidogrel. Genetic testing reveals the patient is a poor metabolizer of
CYP2C19. How might this impact therapy?
The patient may not effectively convert clopidogrel into its active form, reducing its
efficacy.
8. Which gene variant should be considered before prescribing codeine to a patient, as it can
affect the drug's metabolism and efficacy?
CYP2D6
9. A patient with liver disease is prescribed acetaminophen. Which aspect of this prescription
should concern the nurse?
Liver disease may reduce acetaminophen metabolism, increasing the risk of hepatotoxicity.
10. Which antimicrobial is contraindicated in pregnancy due to its potential to cause permanent
tooth discoloration in the fetus?
Tetracycline
11. When administering vancomycin, what infusion consideration should the nurse keep in mind
to prevent "red man syndrome"?
2
, Infuse vancomycin slowly over at least 60 minutes.
12. A patient with cystic fibrosis requires high doses of aminoglycosides. Which genetic factor
might affect the dosing of this medication?
Variations in CFTR genes that may influence drug pharmacokinetics.
13. The patient has overdosed on benzodiazepines. Which antidote should the nurse administer?
Flumazenil
14. A patient on warfarin therapy has genetic testing that reveals a VKORC1 mutation. What
effect might this mutation have on therapy?
It may increase sensitivity to warfarin, necessitating a lower dose.
15. A nurse is caring for a patient who has overdosed on beta-blockers. What is the
recommended antidote?
Glucagon
16. A nurse is monitoring a patient on linezolid. Why should dietary restrictions on tyramine be
recommended?
Linezolid is an MAOI and can cause hypertensive crisis if combined with high-tyramine
foods.
17. What is the mechanism of action for naloxone in opioid toxicity?
3
, Naloxone reverses opioid toxicity by acting as an opioid receptor antagonist.
18. In the case of acetaminophen overdose, what compound does N-acetylcysteine help to restore
in the liver?
Glutathione
19. A patient on fluoroquinolones reports joint pain. What should the nurse consider regarding
fluoroquinolone therapy?
Discontinuing the medication, as it may be related to tendonitis or tendon rupture.
20. Which pharmacogenomic test might be ordered for a patient starting treatment with
carbamazepine to avoid a severe dermatologic reaction?
HLA-B*1502
21. A patient taking a sulfonamide develops symptoms of hemolysis. The nurse suspects which
genetic deficiency?
G6PD deficiency
22. A nurse is caring for a patient with an alcohol use disorder. Which antibiotic should be
avoided due to the risk of severe adverse effects with alcohol?
Metronidazole
4
Pharmacology Midterm (Complete
Solutions) | Latest Q&A
1. A patient with a confirmed MRSA infection has been prescribed vancomycin. What is an
important nursing consideration when administering this medication?
Monitor trough levels to prevent toxicity.
2. A nurse is administering gentamicin to a patient. Which assessment is crucial to monitor for
toxicity?
Hearing and renal function, as gentamicin can cause ototoxicity and nephrotoxicity.
3. Which antibiotic is associated with a high risk of tendon rupture, especially in older adults?
Fluoroquinolones
4. A patient has been prescribed isoniazid for latent tuberculosis. The nurse should recommend
which supplement to prevent neuropathy?
Vitamin B6 (pyridoxine)
5. A nurse is educating a patient about metronidazole for a bacterial infection. What should the
nurse advise regarding alcohol consumption?
Avoid alcohol, as it may cause a disulfiram-like reaction.
1
,6. For patients with a known deficiency in G6PD, which class of drugs should be avoided due to
the risk of hemolysis?
Sulfonamides
7. A patient is prescribed clopidogrel. Genetic testing reveals the patient is a poor metabolizer of
CYP2C19. How might this impact therapy?
The patient may not effectively convert clopidogrel into its active form, reducing its
efficacy.
8. Which gene variant should be considered before prescribing codeine to a patient, as it can
affect the drug's metabolism and efficacy?
CYP2D6
9. A patient with liver disease is prescribed acetaminophen. Which aspect of this prescription
should concern the nurse?
Liver disease may reduce acetaminophen metabolism, increasing the risk of hepatotoxicity.
10. Which antimicrobial is contraindicated in pregnancy due to its potential to cause permanent
tooth discoloration in the fetus?
Tetracycline
11. When administering vancomycin, what infusion consideration should the nurse keep in mind
to prevent "red man syndrome"?
2
, Infuse vancomycin slowly over at least 60 minutes.
12. A patient with cystic fibrosis requires high doses of aminoglycosides. Which genetic factor
might affect the dosing of this medication?
Variations in CFTR genes that may influence drug pharmacokinetics.
13. The patient has overdosed on benzodiazepines. Which antidote should the nurse administer?
Flumazenil
14. A patient on warfarin therapy has genetic testing that reveals a VKORC1 mutation. What
effect might this mutation have on therapy?
It may increase sensitivity to warfarin, necessitating a lower dose.
15. A nurse is caring for a patient who has overdosed on beta-blockers. What is the
recommended antidote?
Glucagon
16. A nurse is monitoring a patient on linezolid. Why should dietary restrictions on tyramine be
recommended?
Linezolid is an MAOI and can cause hypertensive crisis if combined with high-tyramine
foods.
17. What is the mechanism of action for naloxone in opioid toxicity?
3
, Naloxone reverses opioid toxicity by acting as an opioid receptor antagonist.
18. In the case of acetaminophen overdose, what compound does N-acetylcysteine help to restore
in the liver?
Glutathione
19. A patient on fluoroquinolones reports joint pain. What should the nurse consider regarding
fluoroquinolone therapy?
Discontinuing the medication, as it may be related to tendonitis or tendon rupture.
20. Which pharmacogenomic test might be ordered for a patient starting treatment with
carbamazepine to avoid a severe dermatologic reaction?
HLA-B*1502
21. A patient taking a sulfonamide develops symptoms of hemolysis. The nurse suspects which
genetic deficiency?
G6PD deficiency
22. A nurse is caring for a patient with an alcohol use disorder. Which antibiotic should be
avoided due to the risk of severe adverse effects with alcohol?
Metronidazole
4
