Pre-Naplex Practice Exam| Final Mock
Rehearsal| Latest Q&A 2025|A level
**What is the mechanism of action of beta-blockers in the treatment of hypertension?**
Beta-blockers decrease heart rate and contractility by blocking beta-adrenergic receptors,
reducing cardiac output and lowering blood pressure.
**How do angiotensin-converting enzyme (ACE) inhibitors lower blood pressure?**
ACE inhibitors block the conversion of angiotensin I to angiotensin II, leading to vasodilation
and decreased aldosterone secretion, reducing blood pressure.
**What is the therapeutic range for digoxin in the treatment of heart failure?**
The therapeutic range is 0.5 to 0.9 ng/mL.
**What is a major adverse effect of statins, particularly at high doses?**
Myopathy and rhabdomyolysis
**What is the antidote for warfarin overdose?**
Vitamin K
**What is the mechanism of action of proton pump inhibitors (PPIs)?**
1
, PPIs inhibit the H+/K+ ATPase enzyme in the stomach lining, reducing gastric acid secretion.
**What monitoring is necessary for a patient on warfarin?**
INR (International Normalized Ratio) should be regularly monitored to ensure therapeutic
anticoagulation without increased risk of bleeding.
**Which drug is commonly used in the treatment of type 2 diabetes mellitus to improve insulin
sensitivity?**
Metformin
**What is the first-line treatment for status epilepticus?**
Intravenous lorazepam or diazepam
**How does albuterol help in the management of asthma?**
Albuterol is a short-acting beta-2 agonist that relaxes bronchial smooth muscles, leading to
bronchodilation.
**What is the maximum recommended daily dose of acetaminophen for adults to avoid
hepatotoxicity?**
4 grams per day
2
, **Which antibiotic class is associated with a risk of tendon rupture, particularly in older
adults?**
Fluoroquinolones
**What is the primary use of filgrastim in cancer patients?**
To stimulate the production of neutrophils and reduce the risk of infection in patients
undergoing chemotherapy.
**Which opioid antagonist is used to reverse opioid overdose?**
Naloxone
**What is the recommended first-line treatment for uncomplicated urinary tract infections
(UTIs) in women?**
Nitrofurantoin or trimethoprim/sulfamethoxazole (Bactrim)
**Which medication requires close monitoring of thyroid function during treatment?**
Amiodarone
**What is the mechanism of action of selective serotonin reuptake inhibitors (SSRIs)?**
SSRIs inhibit the reuptake of serotonin in the brain, increasing its availability and improving
mood.
3
Rehearsal| Latest Q&A 2025|A level
**What is the mechanism of action of beta-blockers in the treatment of hypertension?**
Beta-blockers decrease heart rate and contractility by blocking beta-adrenergic receptors,
reducing cardiac output and lowering blood pressure.
**How do angiotensin-converting enzyme (ACE) inhibitors lower blood pressure?**
ACE inhibitors block the conversion of angiotensin I to angiotensin II, leading to vasodilation
and decreased aldosterone secretion, reducing blood pressure.
**What is the therapeutic range for digoxin in the treatment of heart failure?**
The therapeutic range is 0.5 to 0.9 ng/mL.
**What is a major adverse effect of statins, particularly at high doses?**
Myopathy and rhabdomyolysis
**What is the antidote for warfarin overdose?**
Vitamin K
**What is the mechanism of action of proton pump inhibitors (PPIs)?**
1
, PPIs inhibit the H+/K+ ATPase enzyme in the stomach lining, reducing gastric acid secretion.
**What monitoring is necessary for a patient on warfarin?**
INR (International Normalized Ratio) should be regularly monitored to ensure therapeutic
anticoagulation without increased risk of bleeding.
**Which drug is commonly used in the treatment of type 2 diabetes mellitus to improve insulin
sensitivity?**
Metformin
**What is the first-line treatment for status epilepticus?**
Intravenous lorazepam or diazepam
**How does albuterol help in the management of asthma?**
Albuterol is a short-acting beta-2 agonist that relaxes bronchial smooth muscles, leading to
bronchodilation.
**What is the maximum recommended daily dose of acetaminophen for adults to avoid
hepatotoxicity?**
4 grams per day
2
, **Which antibiotic class is associated with a risk of tendon rupture, particularly in older
adults?**
Fluoroquinolones
**What is the primary use of filgrastim in cancer patients?**
To stimulate the production of neutrophils and reduce the risk of infection in patients
undergoing chemotherapy.
**Which opioid antagonist is used to reverse opioid overdose?**
Naloxone
**What is the recommended first-line treatment for uncomplicated urinary tract infections
(UTIs) in women?**
Nitrofurantoin or trimethoprim/sulfamethoxazole (Bactrim)
**Which medication requires close monitoring of thyroid function during treatment?**
Amiodarone
**What is the mechanism of action of selective serotonin reuptake inhibitors (SSRIs)?**
SSRIs inhibit the reuptake of serotonin in the brain, increasing its availability and improving
mood.
3
