NR507 MIDTERM EXAM BEST
QUASTION AND ANSWERS ASSURED
100% GRADED A+!!
Innate immunity (correct answer)the immunity we are born with
Immune response: 3 levels/lines of protection (correct answer)1st line:
physical, mechanical, & biochemical barriers
2nd line: the inflammatory response
3rd line: lymphocyte production
most important immune defense (correct answer)intact skin and mucous
membranes (impermeable barrier)
PAMP (correct answer)pathogen associated molecular pattern
surfaces of bacteria, viruses, and other microbes are covered with many
foreign proteins
foreign
,DAMP (correct answer)damage associated molecular pattern
many proteins are released from inside our cells when they are damaged
foreign
PRR (correct answer)pattern recognition receptors
surfaces of WBCs contain these receptor sites
-continuously interact with any material they encounter to ID it as "self"
or "non-self" (foreign; PAMP or DAMP)
Chemotaxis (correct answer)Cell movement that occurs in response to
chemical stimulus
Phagocytosis (correct answer)"cell eating"
1. opsonization and adherence
2. engulfment - WBC surrounds and ingests Ag
3. Fusion of phagosome with lysosome
4. destruction - phagosome digested by lysozyme, H202, acids, and
other toxic chemicals inside the lysosomes
5. egestion
Hypersensitivity Type 1:_____ (correct answer)Allergic reaction
,Hypersensitivity: Type 1
Mediated by ______ (correct answer)IgE
Hypersensitivity: Type 1
Inflammation due to _____________ (correct answer)mast cell
degranulation
Hypersensitivity: Type 1
local symptoms (correct answer)itching, rash
Hypersensitivity: Type 1
systemic symptoms (correct answer)wheezing
Hypersensitivity: Type 1
most dangerous form (correct answer)anaphylactic reaction-systemic
response-hypotension, severe bronchoconstriction
Hypersensitivity: Type 1
main treatment ___________ (correct answer)epinephrine
Hypersensitivity Type 2: _________________ (correct
answer)Cytotoxic reaction; tissue specific (example: thyroid tissue)
hapten causes mediation of IgE or IgM
, Hypersensitivity: Type 2
Primary effector cells involved (correct answer)macrophages
Hypersensitivity: Type 2
can cause ____________ (correct answer)tissue damage or alter function
Hypersensitivity: Type 2
example of altered function (correct answer)graves disease
(hyperthyroidism)-example of altering thyroid function, but does not
destroy thyroid tissue
Hypersensitivity: Type 2
example of tissue damage (correct answer)incompatible blood type-
example of cell/tissue damage that occurs; severe transfusion reaction
occurs and the transfused erythrocytes are destroyed by agglutination or
complement-mediated lysis
Hypersensitivity: Type 3 (correct answer)Not organ specific
Immune complex-mediated hypersensitivity reactions
-the antibody binds to soluble antigen outside the cell surface and the
complex is deposited in the tissues
Hypersensitivity: Type 3
QUASTION AND ANSWERS ASSURED
100% GRADED A+!!
Innate immunity (correct answer)the immunity we are born with
Immune response: 3 levels/lines of protection (correct answer)1st line:
physical, mechanical, & biochemical barriers
2nd line: the inflammatory response
3rd line: lymphocyte production
most important immune defense (correct answer)intact skin and mucous
membranes (impermeable barrier)
PAMP (correct answer)pathogen associated molecular pattern
surfaces of bacteria, viruses, and other microbes are covered with many
foreign proteins
foreign
,DAMP (correct answer)damage associated molecular pattern
many proteins are released from inside our cells when they are damaged
foreign
PRR (correct answer)pattern recognition receptors
surfaces of WBCs contain these receptor sites
-continuously interact with any material they encounter to ID it as "self"
or "non-self" (foreign; PAMP or DAMP)
Chemotaxis (correct answer)Cell movement that occurs in response to
chemical stimulus
Phagocytosis (correct answer)"cell eating"
1. opsonization and adherence
2. engulfment - WBC surrounds and ingests Ag
3. Fusion of phagosome with lysosome
4. destruction - phagosome digested by lysozyme, H202, acids, and
other toxic chemicals inside the lysosomes
5. egestion
Hypersensitivity Type 1:_____ (correct answer)Allergic reaction
,Hypersensitivity: Type 1
Mediated by ______ (correct answer)IgE
Hypersensitivity: Type 1
Inflammation due to _____________ (correct answer)mast cell
degranulation
Hypersensitivity: Type 1
local symptoms (correct answer)itching, rash
Hypersensitivity: Type 1
systemic symptoms (correct answer)wheezing
Hypersensitivity: Type 1
most dangerous form (correct answer)anaphylactic reaction-systemic
response-hypotension, severe bronchoconstriction
Hypersensitivity: Type 1
main treatment ___________ (correct answer)epinephrine
Hypersensitivity Type 2: _________________ (correct
answer)Cytotoxic reaction; tissue specific (example: thyroid tissue)
hapten causes mediation of IgE or IgM
, Hypersensitivity: Type 2
Primary effector cells involved (correct answer)macrophages
Hypersensitivity: Type 2
can cause ____________ (correct answer)tissue damage or alter function
Hypersensitivity: Type 2
example of altered function (correct answer)graves disease
(hyperthyroidism)-example of altering thyroid function, but does not
destroy thyroid tissue
Hypersensitivity: Type 2
example of tissue damage (correct answer)incompatible blood type-
example of cell/tissue damage that occurs; severe transfusion reaction
occurs and the transfused erythrocytes are destroyed by agglutination or
complement-mediated lysis
Hypersensitivity: Type 3 (correct answer)Not organ specific
Immune complex-mediated hypersensitivity reactions
-the antibody binds to soluble antigen outside the cell surface and the
complex is deposited in the tissues
Hypersensitivity: Type 3
