DEGENERATIVE DISORDERS & ACCUMULATIONS

DEGENERATIVE DISORDERS & ACCUMULATIONS Intracellular accumulations  Manifestations of cellular metabolic derangement that accumulates substances within the cells.  May accumulate cellular components or abnormal substances or pigments e.g I. Normal endogenous substances: May be produced at normal rates. The metabolic rate of its removal is inadequate e.g fatty change. II. Normal or abnormal endogenous substances: accumulating because of genetic or acquired defects in its metabolism, packaging, transport or secretion e.g storage diseases. III. Abnormal exogenous substances: Deposited or accumulating because the cell does not have the enzyme system to degrade it or transport to other sites e.g anthracosis. Substances that accumulat