HEME ONLINE BOOK QUESTIONS AND
VERIFIED ANSWERS
A physician wants to obtain a measure of a patient's iron stores. Which
of the following tests would be the most suitable?
a. Serum iron
b. Serum transferrin (TIBC)
c. Serum ferritin
d. Transferrin saturation - ANSWER Serum ferritin
2. A 68-year-old woman visited her physician with reports of fatigue and
weakness. A CBC was ordered, and the patient's results were as
follows: RBC 2.50 × 1012/ L Hct 18.8% MCH 24.8 pg Hgb 6.2 g/ dL
MCV 75.2 fL MCHC 33% Which of the following would be a plausible
diagnosis for this patient?
a. Iron-deficiency anaemia
b. Vitamin B12 deficiency
c. Anemia of chronic inflammation
d. Hemochromatosis - ANSWER Iron-deficiency anemia
3. A peripheral smear shows a decreased RBC count with microcytic,
hypochromic cells with small grapelike inclusions in the RBCs on both
Wright stain and Prussian blue stain. This is consistent with:
a. Iron-deficiency anemia
b. Sideroblastic anemia
c. Pernicious anemia
d. β-Thalassemia minor - ANSWER Sideroblastic anemia
4. Given the following results of iron studies, which disorder is the most
likely? ↓ Serum iron ↑ TIBC ↓ Ferritin ↓ % Saturation
a. Iron-deficiency anemia
b. Sideroblastic anemia
c. Anemia of chronic inflammation
d. Hemochromatosis - ANSWER Iron-deficiency anemia
5. Acquired sideroblastic anemia may be present in all of the following
except:
,a. Alcoholism
b. Lead poisoning
c. Malabsorption
d. Myelodysplastic syndromes - ANSWER Malabsorption
6. A patient has a macrocytic anemia, and the physician suspects
pernicious anemia. Which test would best rule in a definitive diagnosis of
pernicious anemia?
a. Homocysteine
b. Intrinsic factor antibodies
c. Ova and parasite examination for D. latum
d. Bone marrow examination - ANSWER Intrinsic factor antibodies
7. Megaloblastic anemias result from which of the following?
a. Deficiencies in free erythrocyte protoporphyrin
b. Deficiencies in Vitamin B12 and folic acid
c. Increases in iron and hepcidin
d. Decreases in liver function - ANSWER Deficiencies in Vitamin B12
and folic acid
8. A patient's bone marrow showed erythroid hyperplasia with signs of
dysplastic maturation, particularly in the RBC precursors. This is
consistent with which of the following?
a. Sickle cell anemia
b. β-Thalassemia major
c. Pernicious anemia
d. G6PD deficiency - ANSWER Pernicious anemia
9. The CBC for a 57-year-old man had the following results. Which tests
would be best to order next? RBC 2.50 × 1012/ L Hct 26.0% MCH 34 pg
Hgb 8.5 g/ dL MCV 104 fL MCHC 33%
a. Iron studies
b. Vitamin B12 and folic acid levels
c. Bone marrow examination
d. Intrinsic factor antibodies - ANSWER Vitamin B12 and folic acid levels
10. The majority of acquired aplastic anemia cases usually results from
which of the following?
, a. Unknown causes
b. Pregnancy
c. Chloramphenicol exposure
d. Radiation exposure - ANSWER Unknown causes
11. Which of the following values is the most likely to be normal in a
patient with aplastic anemia?
a. RBC count
b. Absolute neutrophil count
c. Absolute lymphocyte count
d. Platelet count - ANSWER Absolute lymphocyte count
12. Fanconi's anemia is an inherited aplastic anemia with mutations that
lead to:
a. Increased chromosome fragility
b. Myelophthisic anemia
c. Pancreatic issues
d. RBC enzymatic defects - ANSWER Increased chromosome fragility
13. Which of the following is decreased in cases of intravascular
hemolytic anemia?
a. Bilirubin
b. Urine hemosiderin
c. Haptoglobin
d. Plasma hemoglobin - ANSWER Haptoglobin
14. Typical CBC findings in hemolytic anemia include:
a. Microcytic, hypochromic cells with increased poikilocytosis
b. Macrocytic, normochromic cells with increased polychromasia
c. Microcytic, normochromic cells with increased poikilocytosis
d. Macrocytic, hypochromic cells with increased polychromasia -
ANSWER Macrocytic, normochromic cells with increased polychromasia
15. Which of the following disorders does not have a hemolytic
component?
a. Sickle cell anemia
b. Autoimmune hemolytic anemia
c. Glucose-6-phosphate dehydrogenase deficiency
VERIFIED ANSWERS
A physician wants to obtain a measure of a patient's iron stores. Which
of the following tests would be the most suitable?
a. Serum iron
b. Serum transferrin (TIBC)
c. Serum ferritin
d. Transferrin saturation - ANSWER Serum ferritin
2. A 68-year-old woman visited her physician with reports of fatigue and
weakness. A CBC was ordered, and the patient's results were as
follows: RBC 2.50 × 1012/ L Hct 18.8% MCH 24.8 pg Hgb 6.2 g/ dL
MCV 75.2 fL MCHC 33% Which of the following would be a plausible
diagnosis for this patient?
a. Iron-deficiency anaemia
b. Vitamin B12 deficiency
c. Anemia of chronic inflammation
d. Hemochromatosis - ANSWER Iron-deficiency anemia
3. A peripheral smear shows a decreased RBC count with microcytic,
hypochromic cells with small grapelike inclusions in the RBCs on both
Wright stain and Prussian blue stain. This is consistent with:
a. Iron-deficiency anemia
b. Sideroblastic anemia
c. Pernicious anemia
d. β-Thalassemia minor - ANSWER Sideroblastic anemia
4. Given the following results of iron studies, which disorder is the most
likely? ↓ Serum iron ↑ TIBC ↓ Ferritin ↓ % Saturation
a. Iron-deficiency anemia
b. Sideroblastic anemia
c. Anemia of chronic inflammation
d. Hemochromatosis - ANSWER Iron-deficiency anemia
5. Acquired sideroblastic anemia may be present in all of the following
except:
,a. Alcoholism
b. Lead poisoning
c. Malabsorption
d. Myelodysplastic syndromes - ANSWER Malabsorption
6. A patient has a macrocytic anemia, and the physician suspects
pernicious anemia. Which test would best rule in a definitive diagnosis of
pernicious anemia?
a. Homocysteine
b. Intrinsic factor antibodies
c. Ova and parasite examination for D. latum
d. Bone marrow examination - ANSWER Intrinsic factor antibodies
7. Megaloblastic anemias result from which of the following?
a. Deficiencies in free erythrocyte protoporphyrin
b. Deficiencies in Vitamin B12 and folic acid
c. Increases in iron and hepcidin
d. Decreases in liver function - ANSWER Deficiencies in Vitamin B12
and folic acid
8. A patient's bone marrow showed erythroid hyperplasia with signs of
dysplastic maturation, particularly in the RBC precursors. This is
consistent with which of the following?
a. Sickle cell anemia
b. β-Thalassemia major
c. Pernicious anemia
d. G6PD deficiency - ANSWER Pernicious anemia
9. The CBC for a 57-year-old man had the following results. Which tests
would be best to order next? RBC 2.50 × 1012/ L Hct 26.0% MCH 34 pg
Hgb 8.5 g/ dL MCV 104 fL MCHC 33%
a. Iron studies
b. Vitamin B12 and folic acid levels
c. Bone marrow examination
d. Intrinsic factor antibodies - ANSWER Vitamin B12 and folic acid levels
10. The majority of acquired aplastic anemia cases usually results from
which of the following?
, a. Unknown causes
b. Pregnancy
c. Chloramphenicol exposure
d. Radiation exposure - ANSWER Unknown causes
11. Which of the following values is the most likely to be normal in a
patient with aplastic anemia?
a. RBC count
b. Absolute neutrophil count
c. Absolute lymphocyte count
d. Platelet count - ANSWER Absolute lymphocyte count
12. Fanconi's anemia is an inherited aplastic anemia with mutations that
lead to:
a. Increased chromosome fragility
b. Myelophthisic anemia
c. Pancreatic issues
d. RBC enzymatic defects - ANSWER Increased chromosome fragility
13. Which of the following is decreased in cases of intravascular
hemolytic anemia?
a. Bilirubin
b. Urine hemosiderin
c. Haptoglobin
d. Plasma hemoglobin - ANSWER Haptoglobin
14. Typical CBC findings in hemolytic anemia include:
a. Microcytic, hypochromic cells with increased poikilocytosis
b. Macrocytic, normochromic cells with increased polychromasia
c. Microcytic, normochromic cells with increased poikilocytosis
d. Macrocytic, hypochromic cells with increased polychromasia -
ANSWER Macrocytic, normochromic cells with increased polychromasia
15. Which of the following disorders does not have a hemolytic
component?
a. Sickle cell anemia
b. Autoimmune hemolytic anemia
c. Glucose-6-phosphate dehydrogenase deficiency
