MRCPsych Paper A: Questions With Solutions (100%
Correct)
Dorsolateral Prefrontal syndrome Right Ans - Executive dysfunction,
Diminshed planning
Parotitis - seen in which mental disorder Right Ans - 20-year old with Hx of
Bulimia Nervosa that stopped purging 2 days ago presenting with painless
swelling on her face - Dx
Medial prefrontal Syndrome Right Ans - Poverty of speech , Paucity of
spontaneous behaviour
Orbitofrontal syndrome Right Ans - Poor impulse control, Explosive
outbursts
Ideomotor apraxia Right Ans - the inability to carry out a simple motor
activity in response to a verbal command, even though this same activity is
readily performed spontaneously
Ideational apraxia Right Ans - an impairment in the ability to carry out a
sequence of actions, even though each element or step can be done correctly
Visuopatial agnosia Right Ans - Loss of sense of "whereness"
Alpha-synuclein (SNCA) gene Right Ans - Located on chromosome 4
Parkin (PRKN) gene Right Ans - Located on chromosome 6
Genetic causes of Parkinson Disease Right Ans - LRRK2
PARK7
PINK1
PRKN
SNCA
(gene mutations)
Mutated genes in FTD Right Ans - C9ORF72, proteins tau (MAPT),
Progranulin (GRN)
, C9ORF72 gene location Right Ans - 9q21.2 - associated to FTD and ALS
MAPT gene location Right Ans - 17q21.31 - associated to FTD, Parkinson-
17 and PSP
GRN location Right Ans - 17q21.31 - associated to FTD
Huntington gene (HTT) location Right Ans - Chromosome 4
Mamillary Body alpha ketoglutarate Right Ans - Structure implied in
Korsakoff syndrome
Raphe Nuclei Right Ans - Storage site of serotonin
Kleine-Levin Syndrome Right Ans - Sleeping beauty syndrome -
Hypothalamic pathology
Normal development milestones Right Ans - Crawling: 6-9 months
Verbal production: 12 months
Ability to build a tower of 6 cubes: 2 years
Ability to use simple sentences: 3 years
Copying a square: 4 years
Memantine MOA Right Ans - N-Methyl-D-Aspartate (NMDA) Receptor
Antagonist and 5HT3 receptor antagonist
Galantamine MOA Right Ans - selective and reversible Acetylcholinesterase
inhibitor and nicotine modulator
Rivastigmine MOA Right Ans - pseudo-irreversible acetylcholinesterase
inhibitor
Donepezil MOA Right Ans - selective reversible AChE inhibitor
Trazodone → Mirtazapine Right Ans - Cross taper with caution
Fluoxetine → Tranylcypromine (MAOI) Right Ans - Withdraw and wait for
5-6 weeks
Correct)
Dorsolateral Prefrontal syndrome Right Ans - Executive dysfunction,
Diminshed planning
Parotitis - seen in which mental disorder Right Ans - 20-year old with Hx of
Bulimia Nervosa that stopped purging 2 days ago presenting with painless
swelling on her face - Dx
Medial prefrontal Syndrome Right Ans - Poverty of speech , Paucity of
spontaneous behaviour
Orbitofrontal syndrome Right Ans - Poor impulse control, Explosive
outbursts
Ideomotor apraxia Right Ans - the inability to carry out a simple motor
activity in response to a verbal command, even though this same activity is
readily performed spontaneously
Ideational apraxia Right Ans - an impairment in the ability to carry out a
sequence of actions, even though each element or step can be done correctly
Visuopatial agnosia Right Ans - Loss of sense of "whereness"
Alpha-synuclein (SNCA) gene Right Ans - Located on chromosome 4
Parkin (PRKN) gene Right Ans - Located on chromosome 6
Genetic causes of Parkinson Disease Right Ans - LRRK2
PARK7
PINK1
PRKN
SNCA
(gene mutations)
Mutated genes in FTD Right Ans - C9ORF72, proteins tau (MAPT),
Progranulin (GRN)
, C9ORF72 gene location Right Ans - 9q21.2 - associated to FTD and ALS
MAPT gene location Right Ans - 17q21.31 - associated to FTD, Parkinson-
17 and PSP
GRN location Right Ans - 17q21.31 - associated to FTD
Huntington gene (HTT) location Right Ans - Chromosome 4
Mamillary Body alpha ketoglutarate Right Ans - Structure implied in
Korsakoff syndrome
Raphe Nuclei Right Ans - Storage site of serotonin
Kleine-Levin Syndrome Right Ans - Sleeping beauty syndrome -
Hypothalamic pathology
Normal development milestones Right Ans - Crawling: 6-9 months
Verbal production: 12 months
Ability to build a tower of 6 cubes: 2 years
Ability to use simple sentences: 3 years
Copying a square: 4 years
Memantine MOA Right Ans - N-Methyl-D-Aspartate (NMDA) Receptor
Antagonist and 5HT3 receptor antagonist
Galantamine MOA Right Ans - selective and reversible Acetylcholinesterase
inhibitor and nicotine modulator
Rivastigmine MOA Right Ans - pseudo-irreversible acetylcholinesterase
inhibitor
Donepezil MOA Right Ans - selective reversible AChE inhibitor
Trazodone → Mirtazapine Right Ans - Cross taper with caution
Fluoxetine → Tranylcypromine (MAOI) Right Ans - Withdraw and wait for
5-6 weeks
