BCH Exam 3
How is fructose incorporated into glycolysis in adipose tissue? - correct answer ✔✔In adipose tissue,
fructose can be directly converted to F6P by Hexomino , an intermediate in glycolysis.
Adipose-Done directly
How is fructose incorporated into glycolysis in Liver tissue? - correct answer ✔✔- In the liver, fructose
must be phosphorylated to F1P
- Cleaved by F1P aldolase to produce DHAP and glycealdehyde.
- Glyceraldehyde is then phosphorylated to produce G3P.
What are the enzymes that are irreversible in glycolysis? - correct answer ✔✔- Hexsokinase/ glucokinase
- PFK (phsphofructokinase)
- Pyruvate Kinase
What is HEXOKINASE INHIBITED by in the MUSCLE? - correct answer ✔✔- Glucose-6-phosphate!
when a product INHIBITS ITSELF its called NEGATIVE FEEDBACK- FEEDBACK INHIBITION (G6P) is a product
of hexokinase
What is PFK....ACTIVATED/ INHIBITED by in the MUSCLE? - correct answer ✔✔PFK
ACTIVATED- BY AMP- sign that you do not have enough Energy
INHIBITED- ATP- because ATP is a sign that you have too much energy already so why do glycolysis
, What is PYRUVATE KINASE...ACTIVATED/ INHIBITED by in the MUSCLE? - correct answer ✔✔PYRUVATE
KINASE
ACTIVATED- FRUCTOSE 1,6 BISPHOSPHATE
- Glycolysis intermediate- sign that pyruvate kinase needs to make more enrgy
INHIBITED- ATP & ALANINE
ATP is a sign that you have too much energy already so why do glycolysis
ALANINE is a sign that too much pyruvate no one
What is HEXOKINASE/GLUCOKINASE controled by in the LIVER? - correct answer
✔✔Hexokinase/Glucokinase in liver is controlled by blood glucose level alone.
What is PFK....ACTIVATED/ INHIBITED by in the LIVER? - correct answer ✔✔ACTIVATED- FRUCTOSE-2,6-
BISPHOSPHATE
- F26BP is NOT a glycolytic intermediate but is similar to F16BP
- Imagine that there is an accumulation of F6P because PFK is NOT working hard enough
INHIBITED- CITRATE, ATP
Citrate is a compound that INHIBITS PFK in the Liver
- Pyruvate will eventually become citrate, citrate is an inhibitor because it is a product and a sign that
there is too much (product) you do not need anymore
How is fructose incorporated into glycolysis in adipose tissue? - correct answer ✔✔In adipose tissue,
fructose can be directly converted to F6P by Hexomino , an intermediate in glycolysis.
Adipose-Done directly
How is fructose incorporated into glycolysis in Liver tissue? - correct answer ✔✔- In the liver, fructose
must be phosphorylated to F1P
- Cleaved by F1P aldolase to produce DHAP and glycealdehyde.
- Glyceraldehyde is then phosphorylated to produce G3P.
What are the enzymes that are irreversible in glycolysis? - correct answer ✔✔- Hexsokinase/ glucokinase
- PFK (phsphofructokinase)
- Pyruvate Kinase
What is HEXOKINASE INHIBITED by in the MUSCLE? - correct answer ✔✔- Glucose-6-phosphate!
when a product INHIBITS ITSELF its called NEGATIVE FEEDBACK- FEEDBACK INHIBITION (G6P) is a product
of hexokinase
What is PFK....ACTIVATED/ INHIBITED by in the MUSCLE? - correct answer ✔✔PFK
ACTIVATED- BY AMP- sign that you do not have enough Energy
INHIBITED- ATP- because ATP is a sign that you have too much energy already so why do glycolysis
, What is PYRUVATE KINASE...ACTIVATED/ INHIBITED by in the MUSCLE? - correct answer ✔✔PYRUVATE
KINASE
ACTIVATED- FRUCTOSE 1,6 BISPHOSPHATE
- Glycolysis intermediate- sign that pyruvate kinase needs to make more enrgy
INHIBITED- ATP & ALANINE
ATP is a sign that you have too much energy already so why do glycolysis
ALANINE is a sign that too much pyruvate no one
What is HEXOKINASE/GLUCOKINASE controled by in the LIVER? - correct answer
✔✔Hexokinase/Glucokinase in liver is controlled by blood glucose level alone.
What is PFK....ACTIVATED/ INHIBITED by in the LIVER? - correct answer ✔✔ACTIVATED- FRUCTOSE-2,6-
BISPHOSPHATE
- F26BP is NOT a glycolytic intermediate but is similar to F16BP
- Imagine that there is an accumulation of F6P because PFK is NOT working hard enough
INHIBITED- CITRATE, ATP
Citrate is a compound that INHIBITS PFK in the Liver
- Pyruvate will eventually become citrate, citrate is an inhibitor because it is a product and a sign that
there is too much (product) you do not need anymore
