BCH Final Exam Review
Which of the following statements regarding hydrogen bonding is FALSE?
- H-bonding is one of the most important non-covalent bonds in biochemistry.
- H-bonds occur in assemblies of proteins where individual supramolecular structure undergo
intermolecular interactions.
- In an H-bond, the acceptor is a weak acid and the donor is a weak base.
- The linear overlap of the anti-bonding orbital of the donor H and bonding orbital of the acceptor lone
pair electrons is critical to an H-bond
- While an individual H-bond is moderately strong, the presence of groups of H-bonds contributes to the
stability of large biomolecular structures. - correct answer ✔✔Answer: In an H-bond, the acceptor is a
weak acid and the donor is a weak base.
True or False: Polymer formation from a pool of available monomers with a range of chemical
functionalities contributes to biochemical molecular complexity. - correct answer ✔✔True
Which of the following statements about compartmentation is FALSE?
- By decreasing environmental variability in a microdomain, compartmentation promotes life.
- High concentrations of biomolecules are too energetically expensive to keep within a compartment.
- Compartmentation is necessary to isolate cellular components from the bulk environment.
- Microdomains form through self-assembly processes, partitioning the cell into compartments.
- Chemical evolution would not possible without compartmentation. - correct answer ✔✔Answer: High
concentrations of biomolecules are too energetically expensive to keep within a compartment.
True or False: The optimal bond distance in charge-charge interactions is determined exclusively by the
potential energy of attraction. - correct answer ✔✔False
The Miller-Urey experiment was conducted in order to...
,- ...simulate the surface of a meteorite.
- ....demonstrate that life began with the help of lightning as a source of energy.
- ...show that the elevated temperature of primordial Earth initiated life.
- ...demonstrate that buildings blocks of life needed oxygen to form.
- ...simulate gas exchange from plants that promote life on Earth. - correct answer
✔✔Answer: ....demonstrate that life began with the help of lightning as a source of energy.
Given the image below, indicate the non-covalent bond. - correct answer ✔✔Bond 2 (between 2 bases)
-- It is a hydrogen bond
What non-covalent interaction(s) is/are most likely to occur between water and water? - correct answer
✔✔Hydrogen bonding and dipole-dipole ????
Which of the following statements about the Hydrophobic effect is FALSE?
- Clathrates result in ice-like water, resulting in ΔS<0.
- The formation of a bilayer vesicle from amphiphiles in water results in polar headgroups facing the
aqueous phase.
- The hydrophobic effect is a driving force for biochemical self-assembly.
- The hydrophobic effect is driven by the solute, and is considered a non-covalent intermolecular
interaction.
- Reducing the surface area of a clathrate results in an increase in entropy. - correct answer ✔✔Answer:
The hydrophobic effect is driven by the solute, and is considered a non-covalent intermolecular
interaction.
Given the following titration curve for Lysine and indicated pKa values, the pI for Lysine is: - correct
answer ✔✔10
Given the structure of glycogen below, what is the correct name for the glycosidic linkage indicated by
arrow #1? - correct answer ✔✔α−D−glucosep(1→6)α−D−glucosep
, Name the reaction that results in the chemical transformation of galactose shown below. - correct
answer ✔✔C6 oxidation
The amino acid depicted below is: - correct answer ✔✔L-Glutamic Acid
The amino acid depicted below is: - correct answer ✔✔L-Tryptophan
The amino acid depicted below is: - correct answer ✔✔D-Arginine
Which of the following statements regarding cellular lipid membranes is FALSE?
- The distribution of lipids in the cell membrane is asymmetrical between inner and outer leaflets.
- The lipid composition of cell membranes impacts glycosylation patterns, transmembrane protein
distribution, and membrane transport.
- The cell membrane lipids can readily diffuse within leaflets, but require energy to flip between leaflets.
- Glycerophospholipids are the major lipid component of plant and archaea cell membranes.
- Cholesterol is necessary for proper cell membrane function, promoting membrane rigidification. -
correct answer ✔✔Answer: Glycerophospholipids are the major lipid component of plant and archaea
cell membranes.
The beta-branched amino acid depicted below is: - correct answer ✔✔L-D Threonine
True or False: Processes that result in ΔSuniverse>0 will yield a ΔG>0 - correct answer ✔✔False
Given the biopolymer below, match the numbered component with the moiety description provided. -
correct answer ✔✔Know where these bonds are:
- Phosphodiester group
- Glycosidic bond
- Anomeric carbon
- C2' hydroxyl
Which of the following statements regarding hydrogen bonding is FALSE?
- H-bonding is one of the most important non-covalent bonds in biochemistry.
- H-bonds occur in assemblies of proteins where individual supramolecular structure undergo
intermolecular interactions.
- In an H-bond, the acceptor is a weak acid and the donor is a weak base.
- The linear overlap of the anti-bonding orbital of the donor H and bonding orbital of the acceptor lone
pair electrons is critical to an H-bond
- While an individual H-bond is moderately strong, the presence of groups of H-bonds contributes to the
stability of large biomolecular structures. - correct answer ✔✔Answer: In an H-bond, the acceptor is a
weak acid and the donor is a weak base.
True or False: Polymer formation from a pool of available monomers with a range of chemical
functionalities contributes to biochemical molecular complexity. - correct answer ✔✔True
Which of the following statements about compartmentation is FALSE?
- By decreasing environmental variability in a microdomain, compartmentation promotes life.
- High concentrations of biomolecules are too energetically expensive to keep within a compartment.
- Compartmentation is necessary to isolate cellular components from the bulk environment.
- Microdomains form through self-assembly processes, partitioning the cell into compartments.
- Chemical evolution would not possible without compartmentation. - correct answer ✔✔Answer: High
concentrations of biomolecules are too energetically expensive to keep within a compartment.
True or False: The optimal bond distance in charge-charge interactions is determined exclusively by the
potential energy of attraction. - correct answer ✔✔False
The Miller-Urey experiment was conducted in order to...
,- ...simulate the surface of a meteorite.
- ....demonstrate that life began with the help of lightning as a source of energy.
- ...show that the elevated temperature of primordial Earth initiated life.
- ...demonstrate that buildings blocks of life needed oxygen to form.
- ...simulate gas exchange from plants that promote life on Earth. - correct answer
✔✔Answer: ....demonstrate that life began with the help of lightning as a source of energy.
Given the image below, indicate the non-covalent bond. - correct answer ✔✔Bond 2 (between 2 bases)
-- It is a hydrogen bond
What non-covalent interaction(s) is/are most likely to occur between water and water? - correct answer
✔✔Hydrogen bonding and dipole-dipole ????
Which of the following statements about the Hydrophobic effect is FALSE?
- Clathrates result in ice-like water, resulting in ΔS<0.
- The formation of a bilayer vesicle from amphiphiles in water results in polar headgroups facing the
aqueous phase.
- The hydrophobic effect is a driving force for biochemical self-assembly.
- The hydrophobic effect is driven by the solute, and is considered a non-covalent intermolecular
interaction.
- Reducing the surface area of a clathrate results in an increase in entropy. - correct answer ✔✔Answer:
The hydrophobic effect is driven by the solute, and is considered a non-covalent intermolecular
interaction.
Given the following titration curve for Lysine and indicated pKa values, the pI for Lysine is: - correct
answer ✔✔10
Given the structure of glycogen below, what is the correct name for the glycosidic linkage indicated by
arrow #1? - correct answer ✔✔α−D−glucosep(1→6)α−D−glucosep
, Name the reaction that results in the chemical transformation of galactose shown below. - correct
answer ✔✔C6 oxidation
The amino acid depicted below is: - correct answer ✔✔L-Glutamic Acid
The amino acid depicted below is: - correct answer ✔✔L-Tryptophan
The amino acid depicted below is: - correct answer ✔✔D-Arginine
Which of the following statements regarding cellular lipid membranes is FALSE?
- The distribution of lipids in the cell membrane is asymmetrical between inner and outer leaflets.
- The lipid composition of cell membranes impacts glycosylation patterns, transmembrane protein
distribution, and membrane transport.
- The cell membrane lipids can readily diffuse within leaflets, but require energy to flip between leaflets.
- Glycerophospholipids are the major lipid component of plant and archaea cell membranes.
- Cholesterol is necessary for proper cell membrane function, promoting membrane rigidification. -
correct answer ✔✔Answer: Glycerophospholipids are the major lipid component of plant and archaea
cell membranes.
The beta-branched amino acid depicted below is: - correct answer ✔✔L-D Threonine
True or False: Processes that result in ΔSuniverse>0 will yield a ΔG>0 - correct answer ✔✔False
Given the biopolymer below, match the numbered component with the moiety description provided. -
correct answer ✔✔Know where these bonds are:
- Phosphodiester group
- Glycosidic bond
- Anomeric carbon
- C2' hydroxyl
