Pathoma Hemostasis and Related
Disorders
Latest Updated Exam Study Guide
2024
primary hemostasis - ansgoal is to make a platelet plug as
a temporary solution to vessel injury
primary hemostasis pic - ans
primary hemostasis: what happens after injury to the
vessel endothelium - ans1. there is transient
vasoconstirction that occurs
- decrease the blood flow to there before any hemostasis
can begin
primary hemostasis: vasoconstriction mediated by - ans1.
neural reflex
2. endothelial cells release endothelin
endothelin - ans
primary hemostasis: after vasoconstriction, then -
ansplatelet adhesion
primary hemostasis: platelet adhesion - ans1. vWF is
released by two sources;
- platelets via the alpha granules
- endothelial cells in the weibel pilade body
2. vWF binds to the exposed subendothelial collagen
- works as a nidus for platelet adhesion
primary hemostasis: after platelet adhesion - ansplatelet
aggregation
,Pathoma Hemostasis and Related
Disorders
Latest Updated Exam Study Guide
2024
primary hemostasis: platelet activation - ans1. GP1B
receptor binds to vWF
- this causes shape change and activation
primary hemostasis: aggregation - ans1. the platelets
release important molecules such as
1. ADP
- from the desne granules
- induces platelets to express the GPIIbIIIa receptor that is
essental for aggregation
2. thromboxane A2
-- derived from platelet COX
- allows for further aggregation
thromboxane A2 - ans
classic signs and symptoms of disorders of primary
hemostasis - ans1. mucosal and skin bleeding
- epistaxis, hemoptysis, occult blood, hematochezia,
hematuria, menhorragia
2. skin bleeding
- petichiae are small pinpoint
- purpura
- echymosses
,Pathoma Hemostasis and Related
Disorders
Latest Updated Exam Study Guide
2024
--- easy burising
epistaxis - ans
hemoptysis - ans
occult blood - ansno
hematochezia - ans
hematuria - ans
petichiae - ans
purpura - ans
echymosis - ans
Useful lab studies - ans1. platelet count
2. bleeding time
- bit outdated
3. blood smear
- size,
4. bone marrow biopsy
- are the megakaryocytes normal
idiopathic thrombocytopenic purpura: what it do - ansAI
production of IgG against platelet surface protein
-- e.g. GpIIbIIIa
idiopathic thrombocytopenic purpura: fun fact - ansmost
common cause of thrombocytopenia in the blood in *both
children and adults*
, Pathoma Hemostasis and Related
Disorders
Latest Updated Exam Study Guide
2024
idiopathic thrombocytopenic purpura: IgG - ansthey are
produced by plasma cells in the spleen
then, the Ab bound platelets are alter consumed by the
macrophages in the spleen
idiopathic thrombocytopenic purpura: forms - ansacute
- think children
chronic
- think adults, think ppl with AI disease
idiopathic thrombocytopenic purpura: acute form -
anschildren
1. thrombocytopenia weeks after infection or
immunization
2. self0limiting d/o within weeks of pt
Tx: support, esp. with really bad thrombocytopenia
idiopathic thrombocytopenic purpura: chronic form -
ans1. usually F of child bearing age
2. may be primary or secondary
Disorders
Latest Updated Exam Study Guide
2024
primary hemostasis - ansgoal is to make a platelet plug as
a temporary solution to vessel injury
primary hemostasis pic - ans
primary hemostasis: what happens after injury to the
vessel endothelium - ans1. there is transient
vasoconstirction that occurs
- decrease the blood flow to there before any hemostasis
can begin
primary hemostasis: vasoconstriction mediated by - ans1.
neural reflex
2. endothelial cells release endothelin
endothelin - ans
primary hemostasis: after vasoconstriction, then -
ansplatelet adhesion
primary hemostasis: platelet adhesion - ans1. vWF is
released by two sources;
- platelets via the alpha granules
- endothelial cells in the weibel pilade body
2. vWF binds to the exposed subendothelial collagen
- works as a nidus for platelet adhesion
primary hemostasis: after platelet adhesion - ansplatelet
aggregation
,Pathoma Hemostasis and Related
Disorders
Latest Updated Exam Study Guide
2024
primary hemostasis: platelet activation - ans1. GP1B
receptor binds to vWF
- this causes shape change and activation
primary hemostasis: aggregation - ans1. the platelets
release important molecules such as
1. ADP
- from the desne granules
- induces platelets to express the GPIIbIIIa receptor that is
essental for aggregation
2. thromboxane A2
-- derived from platelet COX
- allows for further aggregation
thromboxane A2 - ans
classic signs and symptoms of disorders of primary
hemostasis - ans1. mucosal and skin bleeding
- epistaxis, hemoptysis, occult blood, hematochezia,
hematuria, menhorragia
2. skin bleeding
- petichiae are small pinpoint
- purpura
- echymosses
,Pathoma Hemostasis and Related
Disorders
Latest Updated Exam Study Guide
2024
--- easy burising
epistaxis - ans
hemoptysis - ans
occult blood - ansno
hematochezia - ans
hematuria - ans
petichiae - ans
purpura - ans
echymosis - ans
Useful lab studies - ans1. platelet count
2. bleeding time
- bit outdated
3. blood smear
- size,
4. bone marrow biopsy
- are the megakaryocytes normal
idiopathic thrombocytopenic purpura: what it do - ansAI
production of IgG against platelet surface protein
-- e.g. GpIIbIIIa
idiopathic thrombocytopenic purpura: fun fact - ansmost
common cause of thrombocytopenia in the blood in *both
children and adults*
, Pathoma Hemostasis and Related
Disorders
Latest Updated Exam Study Guide
2024
idiopathic thrombocytopenic purpura: IgG - ansthey are
produced by plasma cells in the spleen
then, the Ab bound platelets are alter consumed by the
macrophages in the spleen
idiopathic thrombocytopenic purpura: forms - ansacute
- think children
chronic
- think adults, think ppl with AI disease
idiopathic thrombocytopenic purpura: acute form -
anschildren
1. thrombocytopenia weeks after infection or
immunization
2. self0limiting d/o within weeks of pt
Tx: support, esp. with really bad thrombocytopenia
idiopathic thrombocytopenic purpura: chronic form -
ans1. usually F of child bearing age
2. may be primary or secondary
