Mayo Clinic – Arrhythmia Test |Questions &
Answers Verified 100% Correct
Which ventricular arrhythmia:
"Loss of function in the KCNQ1-encoded IKs potassium channel?" - ✔✔Long QT
Syndrome/LQTS.
What voltage-gated channel is caused by Congenital LQTS? - ✔✔Voltage-gated potassium
channels.
What is the MEDICATION used to tx Brugada? - ✔✔Quinidine.
Primary Prevention ICD in LQTS? - ✔✔1. QTS > 550 ms and not LQT1
2. LQT2 women, QTc > 500 ms +/- Sx
3. Infants with 2:1 AV block?
4. JLNS (LQTS with deafness)?
Is an ICD always indicated in LQTS? - ✔✔No.
When is an ICD indicated in LQTS? - ✔✔Aborted cardiac arrest.
Rx intolerance or breakthrough.
Screening in LQTS? - ✔✔Mutation-specific gene testing is recommended for family members
and other appropriate relatives subsequently following identification of LQTS-causative
mutation in an index case.
What's the DX: "leaky" RyR2 receptors => calcium release channels? - ✔✔CPVT1.
, How does CPVT1 lead to VT? - ✔✔DAD.
CPVT1-triggered arrhythmias secondary to Delayed After Depolarizations (DADs).
(2/2 diastolic Ca++ overload)What are the 3 indications for ICD placement in CPVT?
What are the 3 indications for ICD placement in CPVT? - ✔✔- Syncope + CPVT1
- Asymptomatic/CPVT1 positive
- RX intolerance or breakthrough
---Syncope Lecture---
What are reversible substrates for which ICD is NOT indicated? - ✔✔1. WPW.
2. VF or PMVT with 48 hours of AMI.
3. Drugs or electrolyte abnormalities.
4. Ablatable arrhythmias in normal hearts (RVOT VT).
1. Board Pearls: any syncope - not tx?
2. Board Pearls: syncope tx, no recurrence for 1 mo?
3. Board Pearls: syncope with low EF or due to VT/VF and no ICD?
4. Board Pearls: Syncope with ICD shock for VT?
5. Board Pearls: ICD shock without syncope?
6. Board Pearls: can professional drivers with an ICD drive? - ✔✔1. Board Pearls: any syncope
- not tx?
No driving.
2. Board Pearls: syncope tx, no recurrence for 1 mo?
Answers Verified 100% Correct
Which ventricular arrhythmia:
"Loss of function in the KCNQ1-encoded IKs potassium channel?" - ✔✔Long QT
Syndrome/LQTS.
What voltage-gated channel is caused by Congenital LQTS? - ✔✔Voltage-gated potassium
channels.
What is the MEDICATION used to tx Brugada? - ✔✔Quinidine.
Primary Prevention ICD in LQTS? - ✔✔1. QTS > 550 ms and not LQT1
2. LQT2 women, QTc > 500 ms +/- Sx
3. Infants with 2:1 AV block?
4. JLNS (LQTS with deafness)?
Is an ICD always indicated in LQTS? - ✔✔No.
When is an ICD indicated in LQTS? - ✔✔Aborted cardiac arrest.
Rx intolerance or breakthrough.
Screening in LQTS? - ✔✔Mutation-specific gene testing is recommended for family members
and other appropriate relatives subsequently following identification of LQTS-causative
mutation in an index case.
What's the DX: "leaky" RyR2 receptors => calcium release channels? - ✔✔CPVT1.
, How does CPVT1 lead to VT? - ✔✔DAD.
CPVT1-triggered arrhythmias secondary to Delayed After Depolarizations (DADs).
(2/2 diastolic Ca++ overload)What are the 3 indications for ICD placement in CPVT?
What are the 3 indications for ICD placement in CPVT? - ✔✔- Syncope + CPVT1
- Asymptomatic/CPVT1 positive
- RX intolerance or breakthrough
---Syncope Lecture---
What are reversible substrates for which ICD is NOT indicated? - ✔✔1. WPW.
2. VF or PMVT with 48 hours of AMI.
3. Drugs or electrolyte abnormalities.
4. Ablatable arrhythmias in normal hearts (RVOT VT).
1. Board Pearls: any syncope - not tx?
2. Board Pearls: syncope tx, no recurrence for 1 mo?
3. Board Pearls: syncope with low EF or due to VT/VF and no ICD?
4. Board Pearls: Syncope with ICD shock for VT?
5. Board Pearls: ICD shock without syncope?
6. Board Pearls: can professional drivers with an ICD drive? - ✔✔1. Board Pearls: any syncope
- not tx?
No driving.
2. Board Pearls: syncope tx, no recurrence for 1 mo?
