lOMoAR cPSD| 37668344
PEBC EE SAMPLE QUESTIONS AND HIGHLITED
ANSWERS 2024|2025 A+
Providing Excellence In Certification For The Pharmacy Profession
Sample Questions
Pharmacist Evaluating Examination Sample Questions
The following sample questions are NOT intended or designed to be a sample examination, and
do NOT represent an exact model of the Pharmacist Evaluating Examination in terms of difficulty
and proportion of topics. However, individually, these questions are intended to be representative,
in format and phrasing style, of the types of questions found on the Pharmacist Evaluating
Examination. They also illustrate a variety of the subject areas contained in the examination
blueprint. Please note that, although these questions are reviewed and updated annually to
ensure currency of content, if guidelines or legislation change in the interim, the answers may not
be accurate.
Please see below for the answers to these sample questions.
BIOMEDICAL SCIENCES
Folic acid has tetrahydrofolate coenzyme activity which is based on the:
pyrimidine ring.
purine ring.
pyrazine ring.
d. pteridine ring.
e. pyridine ring.
Enkephalins are peptides that:
have narcotic antagonist activity.
exert actions resembling those of opioids.
are found only in the central nervous system.
cause blood vessel wall relaxation.
transmit pain impulses.
β-Carotene is the precursor of:
retinol.
thiamine.
calciferol.
riboflavin.
retinoic acid.
Which of the following statements regarding transcription is correct?
a. The enzyme responsible for initiating transcription is RNA polymerase.
The enzyme responsible for initiating transcription is DNA polymerase.
During transcription, the genetic information contained in the nucleotide sequence
of tRNA is translated into a protein structure.
The process of transcription includes the splicing of exons.
Following initiation, the next stage of transcription is termination.
https://www.pebc.ca/index.php/ci_id/3074/la_id/1/print/true/art_id/3126.htm 1/20
, Which of the following organisms is an obligate intracellular bacteria, making it resistant to cell
wall-active antibiotics?
Escherichia coli
Legionella pneumophila
Staphylococcus aureus
Streptococcus pneumoniae
Chlamydophila pneumoniae
Which of the following blood vessels transports nutrient rich blood from the intestines to the
liver?
Hepatic artery
Hepatic portal vein
Great saphenous vein
Inferior vena cava
Superior vena cava
The blood volume of the average adult is approximately:
a. 5 L.
10 L.
15 L.
20 L.
25 L.
In adults, community-acquired pneumonia caused by which of the following organisms is
associated with the highest mortality rate?
Chlamydophila pneumoniae
Mycoplasma pneumoniae
Haemophilus influenzae
Streptococcus pneumoniae
Pneumocystis jirovecii
Which of the following is the major inhibitory neurotransmitter in the brain?
a. Gamma-aminobutyric acid
Dopamine
Glutamate
Acetylcholine
Glycine
Which of the following enzymes catalyzes the synthesis of DNA from viral RNA?
a. Reverse transcriptase
DNA polymerase
RNA polymerase
Endonuclease
Aminoacyl-tRNA synthetase
Of the essential transition metal ions found in the human body, the one present at highest
overall concentration is:
copper.
cobalt.
iron.
manganese.
zinc.
https://www.pebc.ca/index.php/ci_id/3074/la_id/1/print/true/art_id/3126.htm 2/20
, The optic disc is also called the:
blind spot.
cornea.
iris.
pupil.
macula lutea.
If systemic blood pressure decreases, which of the following would occur to help return blood
pressure to normal?
Increased urine production
Increased acetylcholine release
c. Increased aldosterone secretion
d. Increased diameter of systemic arterioles
e. Increased erythropoietin production
PHARMACEUTICAL SCIENCES
If the pKa of phenobarbital is 7.4, what approximate fraction of the drug would be
ionized at pH 8.4?
a. 10%
b. 30%
c. 50%
d. 90%
e. 100%
All of the following statements concerning the lyophilization of a parenteral product
are correct, EXCEPT:
there is minimal loss of activity in heat labile materials.
the liquid must be frozen to below the eutectic temperature.
the solute usually forms an amorphous glass.
the eutectic temperature is the freezing point of the drug solution.
water is removed from the frozen mixture by sublimation.
Dopamine is useful in the treatment of cardiogenic shock because it:
a. selectively dilates renal and mesenteric vascular beds.
does not induce peripheral vasoconstriction.
decreases the force of myocardial contraction.
delays the atrioventricular (AV) conduction time.
prolongs the QT interval on the ECG.
Concentration of a drug in breast milk exceeds that in plasma, if the drug:
a. is basic.
is protein bound.
is acidic but not protein bound.
has a small volume of distribution.
has a large volume of distribution.
Mercapturic acid derivatives in phase II metabolism can result from reactions of:
a. glutathione conjugates.
glucuronide conjugates.
glycine conjugates.
glutamate conjugates.
sulfate conjugates.
https://www.pebc.ca/index.php/ci_id/3074/la_id/1/print/true/art_id/3126.htm 3/20
PEBC EE SAMPLE QUESTIONS AND HIGHLITED
ANSWERS 2024|2025 A+
Providing Excellence In Certification For The Pharmacy Profession
Sample Questions
Pharmacist Evaluating Examination Sample Questions
The following sample questions are NOT intended or designed to be a sample examination, and
do NOT represent an exact model of the Pharmacist Evaluating Examination in terms of difficulty
and proportion of topics. However, individually, these questions are intended to be representative,
in format and phrasing style, of the types of questions found on the Pharmacist Evaluating
Examination. They also illustrate a variety of the subject areas contained in the examination
blueprint. Please note that, although these questions are reviewed and updated annually to
ensure currency of content, if guidelines or legislation change in the interim, the answers may not
be accurate.
Please see below for the answers to these sample questions.
BIOMEDICAL SCIENCES
Folic acid has tetrahydrofolate coenzyme activity which is based on the:
pyrimidine ring.
purine ring.
pyrazine ring.
d. pteridine ring.
e. pyridine ring.
Enkephalins are peptides that:
have narcotic antagonist activity.
exert actions resembling those of opioids.
are found only in the central nervous system.
cause blood vessel wall relaxation.
transmit pain impulses.
β-Carotene is the precursor of:
retinol.
thiamine.
calciferol.
riboflavin.
retinoic acid.
Which of the following statements regarding transcription is correct?
a. The enzyme responsible for initiating transcription is RNA polymerase.
The enzyme responsible for initiating transcription is DNA polymerase.
During transcription, the genetic information contained in the nucleotide sequence
of tRNA is translated into a protein structure.
The process of transcription includes the splicing of exons.
Following initiation, the next stage of transcription is termination.
https://www.pebc.ca/index.php/ci_id/3074/la_id/1/print/true/art_id/3126.htm 1/20
, Which of the following organisms is an obligate intracellular bacteria, making it resistant to cell
wall-active antibiotics?
Escherichia coli
Legionella pneumophila
Staphylococcus aureus
Streptococcus pneumoniae
Chlamydophila pneumoniae
Which of the following blood vessels transports nutrient rich blood from the intestines to the
liver?
Hepatic artery
Hepatic portal vein
Great saphenous vein
Inferior vena cava
Superior vena cava
The blood volume of the average adult is approximately:
a. 5 L.
10 L.
15 L.
20 L.
25 L.
In adults, community-acquired pneumonia caused by which of the following organisms is
associated with the highest mortality rate?
Chlamydophila pneumoniae
Mycoplasma pneumoniae
Haemophilus influenzae
Streptococcus pneumoniae
Pneumocystis jirovecii
Which of the following is the major inhibitory neurotransmitter in the brain?
a. Gamma-aminobutyric acid
Dopamine
Glutamate
Acetylcholine
Glycine
Which of the following enzymes catalyzes the synthesis of DNA from viral RNA?
a. Reverse transcriptase
DNA polymerase
RNA polymerase
Endonuclease
Aminoacyl-tRNA synthetase
Of the essential transition metal ions found in the human body, the one present at highest
overall concentration is:
copper.
cobalt.
iron.
manganese.
zinc.
https://www.pebc.ca/index.php/ci_id/3074/la_id/1/print/true/art_id/3126.htm 2/20
, The optic disc is also called the:
blind spot.
cornea.
iris.
pupil.
macula lutea.
If systemic blood pressure decreases, which of the following would occur to help return blood
pressure to normal?
Increased urine production
Increased acetylcholine release
c. Increased aldosterone secretion
d. Increased diameter of systemic arterioles
e. Increased erythropoietin production
PHARMACEUTICAL SCIENCES
If the pKa of phenobarbital is 7.4, what approximate fraction of the drug would be
ionized at pH 8.4?
a. 10%
b. 30%
c. 50%
d. 90%
e. 100%
All of the following statements concerning the lyophilization of a parenteral product
are correct, EXCEPT:
there is minimal loss of activity in heat labile materials.
the liquid must be frozen to below the eutectic temperature.
the solute usually forms an amorphous glass.
the eutectic temperature is the freezing point of the drug solution.
water is removed from the frozen mixture by sublimation.
Dopamine is useful in the treatment of cardiogenic shock because it:
a. selectively dilates renal and mesenteric vascular beds.
does not induce peripheral vasoconstriction.
decreases the force of myocardial contraction.
delays the atrioventricular (AV) conduction time.
prolongs the QT interval on the ECG.
Concentration of a drug in breast milk exceeds that in plasma, if the drug:
a. is basic.
is protein bound.
is acidic but not protein bound.
has a small volume of distribution.
has a large volume of distribution.
Mercapturic acid derivatives in phase II metabolism can result from reactions of:
a. glutathione conjugates.
glucuronide conjugates.
glycine conjugates.
glutamate conjugates.
sulfate conjugates.
https://www.pebc.ca/index.php/ci_id/3074/la_id/1/print/true/art_id/3126.htm 3/20
