PCB 3233 - Final Exam weigel
Who was Edward Jenner? - correct answer ✔✔discovered the first vaccine (smallpox)
Eosinophils - correct answer ✔✔leukocytes that stain red
Basophils - correct answer ✔✔leukocytes that stain blue
Neutrophils - correct answer ✔✔leukocytes that don't stain well (light pink)
What are the primary adaptive immune cells? - correct answer ✔✔B and T cells
What cells are lymphocytes? - correct answer ✔✔NK, B, and T cells
What does the red pulp of the spleen do? - correct answer ✔✔erythrocyte (RBC) filtration
What does the white pulp of the spleen do? - correct answer ✔✔leukocyte (WBC) filtration
How is iC3b made? - correct answer ✔✔-inactivation by Factor H and I results in an opsonin
-NOT a convertase
DAF stands for - correct answer ✔✔decay accelerating factor
MCP stands for - correct answer ✔✔membrane cofactor protein
alpha2-macroglobulins - correct answer ✔✔inhibit the activity of bacterial proteases
,defensins - correct answer ✔✔are the human version of MAC complex, which creates pores/holes in
pathogenic surfaces
What cell makes up the highest concentration of leukocytes? - correct answer ✔✔neutrophils
pyogenic - correct answer ✔✔pus forming
pyrogenic - correct answer ✔✔fever inducing
CR1 binds to - correct answer ✔✔C3b
CR2 binds to - correct answer ✔✔C3d
CR3 binds to - correct answer ✔✔iC3b
CR4 binds to - correct answer ✔✔LPS on G- bacteria
TLR-3 binds to - correct answer ✔✔dsRNA viruses
TLR-4 binds to - correct answer ✔✔LPS on G- bacteria
TLR-5 binds to - correct answer ✔✔Flagellin
TLR-7 binds to - correct answer ✔✔ssRNA viruses
NOD-1/NOD-2 - correct answer ✔✔recognize bacterial cell components
chemokines - correct answer ✔✔a form of cytokine that directs leukocyte traffic
, cytokines - correct answer ✔✔proinflammatory mediators ( IL-1, IL-6, IL-12, CXCL8, and TNF-alpha)
What cells are NOT in germline configuration? - correct answer ✔✔mature B and mature T cells
IgM - correct answer ✔✔-first Ab produced
-pentameric
-activates complement
-can cross mucosal cells via polyIg receptor
-found in secretions along with IgA
IgG - correct answer ✔✔-highest concentration in blood
-good for neutralization/opsonization
-activates complement
-crosses placenta via the FcRn/FcRB/Brambell receptor
IgA - correct answer ✔✔-can be monomeric or dimeric
-monomeric is found in circulation and dimeric is found in the gut lumen
-principle Ab in secretions
-most abundant in the body
-can cross mucosal cells via polyIg receptor
IgE - correct answer ✔✔-involved in allergic reactions and parasites
-present in serum in low levels
-high affinity for FCeRII found on mast cells, basophils, and activated eosinophils
IgD - correct answer ✔✔-found on the surface of mature, naive B cells (along with IgM)
CDR-X/HV-X - correct answer ✔✔-complementary determining region and hypervariable loop are
synonymous
Who was Edward Jenner? - correct answer ✔✔discovered the first vaccine (smallpox)
Eosinophils - correct answer ✔✔leukocytes that stain red
Basophils - correct answer ✔✔leukocytes that stain blue
Neutrophils - correct answer ✔✔leukocytes that don't stain well (light pink)
What are the primary adaptive immune cells? - correct answer ✔✔B and T cells
What cells are lymphocytes? - correct answer ✔✔NK, B, and T cells
What does the red pulp of the spleen do? - correct answer ✔✔erythrocyte (RBC) filtration
What does the white pulp of the spleen do? - correct answer ✔✔leukocyte (WBC) filtration
How is iC3b made? - correct answer ✔✔-inactivation by Factor H and I results in an opsonin
-NOT a convertase
DAF stands for - correct answer ✔✔decay accelerating factor
MCP stands for - correct answer ✔✔membrane cofactor protein
alpha2-macroglobulins - correct answer ✔✔inhibit the activity of bacterial proteases
,defensins - correct answer ✔✔are the human version of MAC complex, which creates pores/holes in
pathogenic surfaces
What cell makes up the highest concentration of leukocytes? - correct answer ✔✔neutrophils
pyogenic - correct answer ✔✔pus forming
pyrogenic - correct answer ✔✔fever inducing
CR1 binds to - correct answer ✔✔C3b
CR2 binds to - correct answer ✔✔C3d
CR3 binds to - correct answer ✔✔iC3b
CR4 binds to - correct answer ✔✔LPS on G- bacteria
TLR-3 binds to - correct answer ✔✔dsRNA viruses
TLR-4 binds to - correct answer ✔✔LPS on G- bacteria
TLR-5 binds to - correct answer ✔✔Flagellin
TLR-7 binds to - correct answer ✔✔ssRNA viruses
NOD-1/NOD-2 - correct answer ✔✔recognize bacterial cell components
chemokines - correct answer ✔✔a form of cytokine that directs leukocyte traffic
, cytokines - correct answer ✔✔proinflammatory mediators ( IL-1, IL-6, IL-12, CXCL8, and TNF-alpha)
What cells are NOT in germline configuration? - correct answer ✔✔mature B and mature T cells
IgM - correct answer ✔✔-first Ab produced
-pentameric
-activates complement
-can cross mucosal cells via polyIg receptor
-found in secretions along with IgA
IgG - correct answer ✔✔-highest concentration in blood
-good for neutralization/opsonization
-activates complement
-crosses placenta via the FcRn/FcRB/Brambell receptor
IgA - correct answer ✔✔-can be monomeric or dimeric
-monomeric is found in circulation and dimeric is found in the gut lumen
-principle Ab in secretions
-most abundant in the body
-can cross mucosal cells via polyIg receptor
IgE - correct answer ✔✔-involved in allergic reactions and parasites
-present in serum in low levels
-high affinity for FCeRII found on mast cells, basophils, and activated eosinophils
IgD - correct answer ✔✔-found on the surface of mature, naive B cells (along with IgM)
CDR-X/HV-X - correct answer ✔✔-complementary determining region and hypervariable loop are
synonymous
