TEST BANK - PHARMACOLOGY FOR THE
PRIMARY CARE PROVIDER, 4TH EDITION
(EDMUNDS, 2014), CHAPTER 1-73 |
ALL CHAPTERS
Thyroid Pharmacology for the Primary Care Provider
NYIT PA - ANSWER-...
What Does the Thyroid Gland Do? - ANSWER-The thyroid glands function
is to regulate the bodies metabolism
It produces three hormones:
• Thyroxine (T4)
• Triodothyronine (T3)
• Calcitonin
Physiology of the Thyroid Gland - ANSWER-The thyroid gland is under
control by the pituitary gland
When T3 and T4 are low the pituitary gland produces Thyroid
Stimulating Hormone (TSH)
TSH stimulates the thyroid gland to produce more T3 and T4
The pituitary gland senses the rise of thyroid hormones in the blood
serum and decreases the TSH production
The pituitary gland is under control by the hypothalamus which secretes
TSH Releasing Hormone (TRH)
TRH tells the pituitary gland to stimulate TSH
Physiological Effects of Thyroid Hormone - ANSWER-There is no
particular target tissue for thyroid hormone
, Every cell in body is affected by the thyroid hormones
Influence the metabolism of proteins, carbohydrates, lipids, cell
morphology, membrane transport, oxygen consumption and heat
production.
Thyroid hormones are required for normal growth and development
Prevalence of Thyroid Disease - ANSWER-Hypothyroidism is the most
common resulting from iodine deficiency due to diet
Autoimmune is the most common thyroid disorder in iodine-replente
areas of the world
Hypothyroidism Drugs - ANSWER-(1) Levothyroxine Sodium
(2) Liotyronine Sodium
(3) Liotrix
Levothyroxine Sodium: Background/MOA - ANSWER-Levothroid
Synthroid
Levoxine
Maintain plasma T4 and T3 concentrations
A long half life allows for once a day administration
How is Levothyroxine Sodium absorbed? - ANSWER-Through the GI tract
How does oral estrogen affect Levothyroxine Sodium? - ANSWER-
Women need increased dose of therapy
Levothyroxine Sodium: Dose in Healthy Adult - ANSWER-100-200 mcg
PO daily
Levothyroxine Sodium: Dose in Elderly or CV disease - ANSWER-12.5-50
mcg PO daily
Levothyroxine Sodium: Dose in Peds - ANSWER-Depends on age
PRIMARY CARE PROVIDER, 4TH EDITION
(EDMUNDS, 2014), CHAPTER 1-73 |
ALL CHAPTERS
Thyroid Pharmacology for the Primary Care Provider
NYIT PA - ANSWER-...
What Does the Thyroid Gland Do? - ANSWER-The thyroid glands function
is to regulate the bodies metabolism
It produces three hormones:
• Thyroxine (T4)
• Triodothyronine (T3)
• Calcitonin
Physiology of the Thyroid Gland - ANSWER-The thyroid gland is under
control by the pituitary gland
When T3 and T4 are low the pituitary gland produces Thyroid
Stimulating Hormone (TSH)
TSH stimulates the thyroid gland to produce more T3 and T4
The pituitary gland senses the rise of thyroid hormones in the blood
serum and decreases the TSH production
The pituitary gland is under control by the hypothalamus which secretes
TSH Releasing Hormone (TRH)
TRH tells the pituitary gland to stimulate TSH
Physiological Effects of Thyroid Hormone - ANSWER-There is no
particular target tissue for thyroid hormone
, Every cell in body is affected by the thyroid hormones
Influence the metabolism of proteins, carbohydrates, lipids, cell
morphology, membrane transport, oxygen consumption and heat
production.
Thyroid hormones are required for normal growth and development
Prevalence of Thyroid Disease - ANSWER-Hypothyroidism is the most
common resulting from iodine deficiency due to diet
Autoimmune is the most common thyroid disorder in iodine-replente
areas of the world
Hypothyroidism Drugs - ANSWER-(1) Levothyroxine Sodium
(2) Liotyronine Sodium
(3) Liotrix
Levothyroxine Sodium: Background/MOA - ANSWER-Levothroid
Synthroid
Levoxine
Maintain plasma T4 and T3 concentrations
A long half life allows for once a day administration
How is Levothyroxine Sodium absorbed? - ANSWER-Through the GI tract
How does oral estrogen affect Levothyroxine Sodium? - ANSWER-
Women need increased dose of therapy
Levothyroxine Sodium: Dose in Healthy Adult - ANSWER-100-200 mcg
PO daily
Levothyroxine Sodium: Dose in Elderly or CV disease - ANSWER-12.5-50
mcg PO daily
Levothyroxine Sodium: Dose in Peds - ANSWER-Depends on age
