Musculoskeletal, Skin and Connective Tissue/Pharmacology/Aspirin
with refined Questions and Answers 2024/2025
In an aspirin overdose, damage to which cranial nerve (CN) causes tinnitus?✔️✔️CN VIII
(vestibulocochlear)
What are three possible adverse effects of aspirin use?✔️✔️Tinnitus, respiratory alkalosis, and
gastric ulceration
What is a common adverse effect of aspirin in children?✔️✔️Reye syndrome
What are three adverse effects of long-term aspirin use?✔️✔️Interstitial nephritis, acute kidney
injury, and gastrointestinal bleeding
What dose of aspirin can you prescribe to help relieve fever and pain?✔️✔️An intermediate dose
(about 300-2400 mg/day)
At what dose does aspirin begin to work as an antiplatelet agent?✔️✔️A low dose (less than 300
mg/day)
How does aspirin affect prothrombin time (PT), partial thromboplastin time (PTT), and bleeding
time?✔️✔️It has no effect on PT or PTT but increases bleeding time (by irreversibly inhibiting
platelet aggregation)
Describe the acid-base status expected in a patient experiencing an aspirin overdose.✔️✔️An early
stage respiratory alkalosis, which transitions into mixed metabolic acidosis-respiratory alkalosis
What is the mechanism of action of aspirin?✔️✔️Irreversible inhibition of cyclooxygenases (both
COX-1 and COX-2) via covalent acetylation
What dose of aspirin is best for an anti-inflammatory effect?✔️✔️A high dose, or about 2400 to
4000 mg/day
Patients with what two medical conditions are most likely to have an allergic reaction to
aspirin?✔️✔️Asthma or nasal polyps
What is the treatment for an aspirin overdose?✔️✔️Sodium bicarbonate (NaHCO3)
Which drug is given to children as an alternative to aspirin?✔️✔️Acetaminophen to prevent Reye
syndrome
with refined Questions and Answers 2024/2025
In an aspirin overdose, damage to which cranial nerve (CN) causes tinnitus?✔️✔️CN VIII
(vestibulocochlear)
What are three possible adverse effects of aspirin use?✔️✔️Tinnitus, respiratory alkalosis, and
gastric ulceration
What is a common adverse effect of aspirin in children?✔️✔️Reye syndrome
What are three adverse effects of long-term aspirin use?✔️✔️Interstitial nephritis, acute kidney
injury, and gastrointestinal bleeding
What dose of aspirin can you prescribe to help relieve fever and pain?✔️✔️An intermediate dose
(about 300-2400 mg/day)
At what dose does aspirin begin to work as an antiplatelet agent?✔️✔️A low dose (less than 300
mg/day)
How does aspirin affect prothrombin time (PT), partial thromboplastin time (PTT), and bleeding
time?✔️✔️It has no effect on PT or PTT but increases bleeding time (by irreversibly inhibiting
platelet aggregation)
Describe the acid-base status expected in a patient experiencing an aspirin overdose.✔️✔️An early
stage respiratory alkalosis, which transitions into mixed metabolic acidosis-respiratory alkalosis
What is the mechanism of action of aspirin?✔️✔️Irreversible inhibition of cyclooxygenases (both
COX-1 and COX-2) via covalent acetylation
What dose of aspirin is best for an anti-inflammatory effect?✔️✔️A high dose, or about 2400 to
4000 mg/day
Patients with what two medical conditions are most likely to have an allergic reaction to
aspirin?✔️✔️Asthma or nasal polyps
What is the treatment for an aspirin overdose?✔️✔️Sodium bicarbonate (NaHCO3)
Which drug is given to children as an alternative to aspirin?✔️✔️Acetaminophen to prevent Reye
syndrome
