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Summary Oogenesis

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October 3, 2024
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Oogenesis


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Oogenesis

Introduction

Etymology:
The word "ovum" is derived from Latin meaning "egg".
The ova are produced by the female (sexual glands) called the ovaries.
All of them are present at birth and mature through Oogenesis.
Definition:
Oogenesis is the production of ovum (ova) that occurs in the ovary and starts at the embryonic stage.
It is the process whereby oogonia (diploid cells) differentiate into mature oocytes.
Ovum is a haploid female reproductive cell.
Pre-natal Maturation of Ovum

Origin and Migration:
The mature female germ cell is a direct descendant of the primordial germ cells in the human embryo yolk
sac wall at the 3rd week of development.
The cell migrates by amoeboid movement from the yolk sac towards the developing gonad (primitive sac
gland) by the end of the 4th week or beginning of the 5th week.
Differentiation and Division:
Once the primitive germ cells arrive at the gonad of the genetic female, they differentiate into oogonia.
These cells undergo a number of mitotic divisions and are arranged in clusters by the end of the 3rd month
surrounded by flat epithelial cells (follicular cells).
Proliferation and Differentiation:
The majority of the oogonia continue to divide by mitosis while some differentiate into much larger primar
(1°) oocytes.
Immediately after the formation of primary (1°) oocytes, they replicate their DNA and enter into the resting
stage.
Maximum Germ Cells and Degeneration:
By the 5th month of development, the total number of germ cells in the ovary reaches its maximum,
estimated at 7 million.
At this time, cell degeneration begins and many oogonia as well as the primary (1°) oocytes become atret
Some of the primary (1°) oocytes have entered the 1st meiotic division, and most of them are surrounded
flat epithelial cells.
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