Chapter c1 cRBCs cand cPlatelet cPreservation: cHistorical cPerspectives cand cCurrent cTrends
Multiple cChoice
Identify cthe cchoice cthat cbest ccompletes cthe cstatement cor canswers cthe cquestion.
c c c c c1. c Which cmetabolic cpathway cis cresponsible cfor cgenerating c90% cof cthe cATP cfor cthe cRBC?
a. Pentose cphosphate cshunt c. Glycolysis
b. Luebering-Rapoport cshunt d. c Methemoglobin creductase
c c c c c2. cA cunit cof cblood cwas creturned cto cthe cblood cbank cbefore cit cwas cspiked. cApparently cthe cpatient’s
cIV cfailed. cThecunit cof cblood cwas coutside cthe cblood cbank cfor c35 cminutes. cWhich cof cthe cstatements
cbelow cis cmost caccurate?
a. The cunit cof cblood cshould cbe cdiscarded cimmediately.
b. The cunit cof cblood ccan cbe creturned cto cinventory.
c. The cunit cof cblood cmust cbe ctransfused cwithin c4 chours cor cbe cdiscarded cat cthe cend cof cthat ctime.
d. The cunit cof cblood cmust cbe ctransfused cwith c24 chours.
c c c c c3. c What cis cthe caverage cdiameter cof ca cplatelet?
a. 5 cto c10 cµm c. 1 cto c2 cµm
b. 2 cto c4 cµm d. c c c 4 cto c6 cµm
c c c c c4. cIn cthe cnormal chemoglobin-oxygen cdissociation ccurve, cwhat cpercentage cof coxygen cis creleased cto
cthe ctissuescwhen cPO2 c averages c40 cmm cHg?
a. 75% c. 100%
b. c c c 25% d. c 50%
c c c c c5. c What cfactors care cknown cto cinfluence cplatelet cmetabolism cand cfunction?
a. Storage ctemperature c. Platelet ccount
b. Initial cpH d. c All cof cthe cabove
c c c c c6. cWhich cof cthe cfollowing cred cblood ccell cmorphologies cmay cbe cpresent con cthe cperipheral cblood
This cstudy csource cwas cdownloaded cby c100000826342158 cfrom cCourseHero.com con c09-15-2021 c17:54:15
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, csmear cas ca cresultcof closs cof cRBC cmembrane?
a. Spherocytes c. Burr ccells
b. Target ccells d. c Schistocytes
c c c c c7. c What cdoes cthe cterm cautologous ctransfusion crefer cto?
a. A cparent cdonating cblood cfor chis cor cher cchild
b. An cindividual cdonating cblood cfor ca cfriend
c. An cindividual cdonating cblood cfor ca crelative
d. An cindividual cdonating cblood cfor chis cor cher cown ctransfusion
c c c c c8. c What cis cthe cprimary cfunction cof chemoglobin?
a. Iron cmetabolism c. Oxygen ctransport
b. Porphyrin csynthesis d. c Signal ctransduction
c c c c c9. c All cof cthe cfollowing careas cof cred cblood ccell cbiology care ccrucial cfor cnormal cerythrocyte csurvival
c except:
a. Cellular cmetabolism. c. Site cof cthe cABO cantigen cattachment.
b. RBC cmembrane. d. c Hemoglobin cstructure.
This cstudy csource cwas cdownloaded cby c100000826342158 cfrom cCourseHero.com con c09-15-2021 c17:54:15
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, c c c10. c What cis cthe ccorrect cbiochemical ccomposition cof cthe cRBC cmembrane?
a. 52% cprotein, c40% clipid, c8% ccarbohydrate
b. 40% cprotein, c8% clipid, c52% ccarbohydrate
c. 8% cprotein, c52% clipid, c40% ccarbohydrate
d. 8% clipid, c40% ccarbohydrate, c52% cprotein
c c c11. c All cof cthe cfollowing cbiochemical cchanges care cassociated cwith closs cof cred cblood ccell cviability cupon
cstorage
except:
a. Decreased cpH. c. Increased cATP clevel.
b. Loss cof cred cblood ccell cfunction. d. c Decreased cglucose cconsumption.
c c c12. c Which cred cblood ccell cpreservative chas ca cstorage ctime cof c35 cdays?
a. ACD c. AS-1
b. CPDA-1 d. c c c CPD
c c c13. c The cRBC cmembrane cis crelatively cpermeable cto call cof cthe cfollowing cexcept:
a. Chloride. c. Bicarbonate.
b. Sodium. d. cWater.
c c c14. cWhat cpercentage cof cplatelets cis csequestered cin cthe cspleen cas cfunctional creserve cafter cbeing
creleased cfrom cthecbone cmarrow?
a. 30% c. 10%
b. c c c 50% d. c c c 25%
c c c15. c What cis cthe cmajor cbiochemical cconsideration cin cplatelet cstorage?
a. Glucose cmetabolism c. Production cof ccarbon cdioxide
b. Oxygen csupply d. c Regulation cof cpH
c c c16. cWhat cwould cthe chemoglobin-oxygen cdissociation ccurve cdepict cin ca cpatient cexhibiting
cclinical csigns cofcalkalosis?
a. Normal c. Shift cto cthe cright
b. Shift cto cthe cleft d. c None cof cthe cabove
c c c17. c Name cthe cmain clipid ccomponents cof ca cred cblood ccell cmembrane.
a. Phospholipid c. Glycolipid
b. Sphingomyelin d. c Glycophorin cA
c c c18. c The cABO cblood cgroups cwere cdiscovered cin c1901 cby cwhom?
a. Charles cDrew c. Loutit cand cMollison
b. Karl cLandsteiner d. c Edward cLindeman
c c c19. cA cstanding corder cof cplatelets cwas cshipped cto cyour cfacility cby cyour csupplier. cIt cwas cinadvertently
cleft cin cthe ccorner cof cthe cdepartment cuntil cdiscovered c36 chours clater. cWhat cwould cthe cappropriate
caction cbe cfor cthe cbloodcbanker?
a. If cthe ctemperature cin cthe cbox cwas c22 c+/- c2°C cand cthe cplatelet cswirl cseemed cOK, cit
cwould cbecOK cto caccept cthe cunit cinto cinventory.
b. The cplatelets chave cfallen coutside cthe csupplier’s cquality cassurance. cThe cunit
cshould cbe cdiscarded cbecause cthe cpH chas cprobably cdropped ctoo clow cand cplatelet
cactivation chas cbeenccompromised.
c. If cthe ctemperature cwas c1°C cto c6°C cand cthe cplatelet cswirl cseemed cOK, cit cwould cbe cOK cto
This cstudy csource cwas cdownloaded cby c100000826342158 cfrom cCourseHero.com con c09-15-2021 c17:54:15
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, accept cthe cunit cinto cinventory.
d. If cthe cplatelets cappeared cOK cand cpassed cthe cplatelet cswirl ctest cafter cbeing
cplaced con cthecagitator, cthey ccould cbe caccepted cinto cthe cinventory.
c c c20. c Which cmetabolic cpathway cpermits cthe caccumulation cof c2,3 cdiphosphoglycerate c(2,3-DPG)?
a. Glycolysis c. Pentose cphosphate cshunt
b. Luebering-Rapoport cshunt d. c Methemoglobin creductase
c c c21. c All cof cthe cfollowing care cconsistent cwith ca c"shift cto cthe cright" cof cthe chemoglobin-oxygen cdissociation
ccurve
except:
a. Increased c2,3-DPG.
b. 50% cO2 c saturation cto ctissues.
c. Decreased c2,3-DPG.
d. Decreased chemoglobin caffinity cfor cO2.
c c c22. c What cis cthe cnormal cplatelet ccount crange cper ccubic cmillimeter?
a. 100 cto c350 c. 50,000 cto c200,000
b. c c c 150,000 cto c350,000 d. c 350,000 cto c500,000
c c c23. c What ccryoprotective cagent cis cadded cto cred cblood ccells cupon cfreezing?
a. Dextrose c. Glycerol
b. Adsol d. c All cof cthe cabove
c c c24. c If cplatelets care cto cbe cstored cfor c5 cdays con ca crotator, cwhat cis cthe coptimal cstorage ctemperature?
a. 1°C cto c6°C c. 35°C cto c37°C
b. c c c 20°C cto c24°C d. c 1°C cto c10°C
c c c25. c What crole cdo cplatelets cplay cin chemostasis?
a. Maintenance cof cvascular cintegrity
b. Initial carrest cof cbleeding cby cplatelet cplug cformation
c. Stabilization cof cthe chemostatic cplug
d. All cof cthe cabove
c c c26. cWhich cof cthe cfollowing cbest cdescribes c"integral" cmembrane cproteins?
a. Reside cat cthe ccytoplasmic csurface cof cmembrane
b. Span cthe centire cmembrane csurface
c. Form cthe cred cblood ccell ccytoskeleton
d. None cof cthe cabove
c c c27. c How cis cstroma-free chemoglobin csolution cprepared?
a. Outdated cred cblood ccells care cconcentrated, cand cstroma cis cremoved.
b. Outdated cred cblood ccells care cdiluted cwith csaline, cand cstroma cis cremoved.
c. Outdated cred cblood ccells care clysed, cand cstroma cis cremoved.
d. None cof cthe cabove
c c c28. cWhat cis cthe cnormal clife cspan cof can cRBC?
a. 100 cdays c. 120 chours
b. 120 cdays d. c 2 cdays
c c c29. cRegarding closs cof cRBC cmembrane cdeformability, call cof cthe cfollowing care ctrue cexcept:
a. Increase cin cATP clevel.
b. Decrease cin cATP clevel.
This cstudy csource cwas cdownloaded cby c100000826342158 cfrom cCourseHero.com con c09-15-2021 c17:54:15
cGMT c-05:00
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Multiple cChoice
Identify cthe cchoice cthat cbest ccompletes cthe cstatement cor canswers cthe cquestion.
c c c c c1. c Which cmetabolic cpathway cis cresponsible cfor cgenerating c90% cof cthe cATP cfor cthe cRBC?
a. Pentose cphosphate cshunt c. Glycolysis
b. Luebering-Rapoport cshunt d. c Methemoglobin creductase
c c c c c2. cA cunit cof cblood cwas creturned cto cthe cblood cbank cbefore cit cwas cspiked. cApparently cthe cpatient’s
cIV cfailed. cThecunit cof cblood cwas coutside cthe cblood cbank cfor c35 cminutes. cWhich cof cthe cstatements
cbelow cis cmost caccurate?
a. The cunit cof cblood cshould cbe cdiscarded cimmediately.
b. The cunit cof cblood ccan cbe creturned cto cinventory.
c. The cunit cof cblood cmust cbe ctransfused cwithin c4 chours cor cbe cdiscarded cat cthe cend cof cthat ctime.
d. The cunit cof cblood cmust cbe ctransfused cwith c24 chours.
c c c c c3. c What cis cthe caverage cdiameter cof ca cplatelet?
a. 5 cto c10 cµm c. 1 cto c2 cµm
b. 2 cto c4 cµm d. c c c 4 cto c6 cµm
c c c c c4. cIn cthe cnormal chemoglobin-oxygen cdissociation ccurve, cwhat cpercentage cof coxygen cis creleased cto
cthe ctissuescwhen cPO2 c averages c40 cmm cHg?
a. 75% c. 100%
b. c c c 25% d. c 50%
c c c c c5. c What cfactors care cknown cto cinfluence cplatelet cmetabolism cand cfunction?
a. Storage ctemperature c. Platelet ccount
b. Initial cpH d. c All cof cthe cabove
c c c c c6. cWhich cof cthe cfollowing cred cblood ccell cmorphologies cmay cbe cpresent con cthe cperipheral cblood
This cstudy csource cwas cdownloaded cby c100000826342158 cfrom cCourseHero.com con c09-15-2021 c17:54:15
cGMT c-05:00
https://www.coursehero.com/file/25537437/ch01rtf/
, csmear cas ca cresultcof closs cof cRBC cmembrane?
a. Spherocytes c. Burr ccells
b. Target ccells d. c Schistocytes
c c c c c7. c What cdoes cthe cterm cautologous ctransfusion crefer cto?
a. A cparent cdonating cblood cfor chis cor cher cchild
b. An cindividual cdonating cblood cfor ca cfriend
c. An cindividual cdonating cblood cfor ca crelative
d. An cindividual cdonating cblood cfor chis cor cher cown ctransfusion
c c c c c8. c What cis cthe cprimary cfunction cof chemoglobin?
a. Iron cmetabolism c. Oxygen ctransport
b. Porphyrin csynthesis d. c Signal ctransduction
c c c c c9. c All cof cthe cfollowing careas cof cred cblood ccell cbiology care ccrucial cfor cnormal cerythrocyte csurvival
c except:
a. Cellular cmetabolism. c. Site cof cthe cABO cantigen cattachment.
b. RBC cmembrane. d. c Hemoglobin cstructure.
This cstudy csource cwas cdownloaded cby c100000826342158 cfrom cCourseHero.com con c09-15-2021 c17:54:15
cGMT c-05:00
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, c c c10. c What cis cthe ccorrect cbiochemical ccomposition cof cthe cRBC cmembrane?
a. 52% cprotein, c40% clipid, c8% ccarbohydrate
b. 40% cprotein, c8% clipid, c52% ccarbohydrate
c. 8% cprotein, c52% clipid, c40% ccarbohydrate
d. 8% clipid, c40% ccarbohydrate, c52% cprotein
c c c11. c All cof cthe cfollowing cbiochemical cchanges care cassociated cwith closs cof cred cblood ccell cviability cupon
cstorage
except:
a. Decreased cpH. c. Increased cATP clevel.
b. Loss cof cred cblood ccell cfunction. d. c Decreased cglucose cconsumption.
c c c12. c Which cred cblood ccell cpreservative chas ca cstorage ctime cof c35 cdays?
a. ACD c. AS-1
b. CPDA-1 d. c c c CPD
c c c13. c The cRBC cmembrane cis crelatively cpermeable cto call cof cthe cfollowing cexcept:
a. Chloride. c. Bicarbonate.
b. Sodium. d. cWater.
c c c14. cWhat cpercentage cof cplatelets cis csequestered cin cthe cspleen cas cfunctional creserve cafter cbeing
creleased cfrom cthecbone cmarrow?
a. 30% c. 10%
b. c c c 50% d. c c c 25%
c c c15. c What cis cthe cmajor cbiochemical cconsideration cin cplatelet cstorage?
a. Glucose cmetabolism c. Production cof ccarbon cdioxide
b. Oxygen csupply d. c Regulation cof cpH
c c c16. cWhat cwould cthe chemoglobin-oxygen cdissociation ccurve cdepict cin ca cpatient cexhibiting
cclinical csigns cofcalkalosis?
a. Normal c. Shift cto cthe cright
b. Shift cto cthe cleft d. c None cof cthe cabove
c c c17. c Name cthe cmain clipid ccomponents cof ca cred cblood ccell cmembrane.
a. Phospholipid c. Glycolipid
b. Sphingomyelin d. c Glycophorin cA
c c c18. c The cABO cblood cgroups cwere cdiscovered cin c1901 cby cwhom?
a. Charles cDrew c. Loutit cand cMollison
b. Karl cLandsteiner d. c Edward cLindeman
c c c19. cA cstanding corder cof cplatelets cwas cshipped cto cyour cfacility cby cyour csupplier. cIt cwas cinadvertently
cleft cin cthe ccorner cof cthe cdepartment cuntil cdiscovered c36 chours clater. cWhat cwould cthe cappropriate
caction cbe cfor cthe cbloodcbanker?
a. If cthe ctemperature cin cthe cbox cwas c22 c+/- c2°C cand cthe cplatelet cswirl cseemed cOK, cit
cwould cbecOK cto caccept cthe cunit cinto cinventory.
b. The cplatelets chave cfallen coutside cthe csupplier’s cquality cassurance. cThe cunit
cshould cbe cdiscarded cbecause cthe cpH chas cprobably cdropped ctoo clow cand cplatelet
cactivation chas cbeenccompromised.
c. If cthe ctemperature cwas c1°C cto c6°C cand cthe cplatelet cswirl cseemed cOK, cit cwould cbe cOK cto
This cstudy csource cwas cdownloaded cby c100000826342158 cfrom cCourseHero.com con c09-15-2021 c17:54:15
cGMT c-05:00
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, accept cthe cunit cinto cinventory.
d. If cthe cplatelets cappeared cOK cand cpassed cthe cplatelet cswirl ctest cafter cbeing
cplaced con cthecagitator, cthey ccould cbe caccepted cinto cthe cinventory.
c c c20. c Which cmetabolic cpathway cpermits cthe caccumulation cof c2,3 cdiphosphoglycerate c(2,3-DPG)?
a. Glycolysis c. Pentose cphosphate cshunt
b. Luebering-Rapoport cshunt d. c Methemoglobin creductase
c c c21. c All cof cthe cfollowing care cconsistent cwith ca c"shift cto cthe cright" cof cthe chemoglobin-oxygen cdissociation
ccurve
except:
a. Increased c2,3-DPG.
b. 50% cO2 c saturation cto ctissues.
c. Decreased c2,3-DPG.
d. Decreased chemoglobin caffinity cfor cO2.
c c c22. c What cis cthe cnormal cplatelet ccount crange cper ccubic cmillimeter?
a. 100 cto c350 c. 50,000 cto c200,000
b. c c c 150,000 cto c350,000 d. c 350,000 cto c500,000
c c c23. c What ccryoprotective cagent cis cadded cto cred cblood ccells cupon cfreezing?
a. Dextrose c. Glycerol
b. Adsol d. c All cof cthe cabove
c c c24. c If cplatelets care cto cbe cstored cfor c5 cdays con ca crotator, cwhat cis cthe coptimal cstorage ctemperature?
a. 1°C cto c6°C c. 35°C cto c37°C
b. c c c 20°C cto c24°C d. c 1°C cto c10°C
c c c25. c What crole cdo cplatelets cplay cin chemostasis?
a. Maintenance cof cvascular cintegrity
b. Initial carrest cof cbleeding cby cplatelet cplug cformation
c. Stabilization cof cthe chemostatic cplug
d. All cof cthe cabove
c c c26. cWhich cof cthe cfollowing cbest cdescribes c"integral" cmembrane cproteins?
a. Reside cat cthe ccytoplasmic csurface cof cmembrane
b. Span cthe centire cmembrane csurface
c. Form cthe cred cblood ccell ccytoskeleton
d. None cof cthe cabove
c c c27. c How cis cstroma-free chemoglobin csolution cprepared?
a. Outdated cred cblood ccells care cconcentrated, cand cstroma cis cremoved.
b. Outdated cred cblood ccells care cdiluted cwith csaline, cand cstroma cis cremoved.
c. Outdated cred cblood ccells care clysed, cand cstroma cis cremoved.
d. None cof cthe cabove
c c c28. cWhat cis cthe cnormal clife cspan cof can cRBC?
a. 100 cdays c. 120 chours
b. 120 cdays d. c 2 cdays
c c c29. cRegarding closs cof cRBC cmembrane cdeformability, call cof cthe cfollowing care ctrue cexcept:
a. Increase cin cATP clevel.
b. Decrease cin cATP clevel.
This cstudy csource cwas cdownloaded cby c100000826342158 cfrom cCourseHero.com con c09-15-2021 c17:54:15
cGMT c-05:00
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