NSG 124
Pharmacology
READINESS EXAM GUIDE
Q&S
©2024/2025
,1. Which of the following is primarily responsible for the
metabolism of drugs?
- A) Liver
- B) Kidney
- C) Intestines
- D) Lungs
Correct Answer: A) Liver
Rationale: The liver contains enzymes that metabolize
drugs, particularly through the cytochrome P450 system.
2. Which of the following pharmacokinetic processes
refers to the movement of drugs into the bloodstream?
- A) Distribution
- B) Absorption
- C) Metabolism
- D) Excretion
Correct Answer: B) Absorption
Rationale: Absorption is the process through which
drugs enter the systemic circulation.
3. What is the term for the dosage of a drug that produces
a therapeutic effect in 50% of the population?
- A) LD50
- B) ED50
- C) TD50
- D) IC50
Correct Answer: B) ED50
Rationale: The ED50 (effective dose 50) is the dose
required to elicit a therapeutic response in half of a tested
population.
4. Which of the following drug routes would avoid first-
©2024/2025
, pass metabolism?
- A) Oral
- B) Intravenous
- C) Subcutaneous
- D) Rectal
Correct Answer: B) Intravenous
Rationale: Intravenous administration delivers drugs
directly into the bloodstream, bypassing the first-pass
metabolism that occurs in the liver.
5. A patient is administered a drug with a high therapeutic
index. Which of the following statements is true?
- A) The drug is highly lethal.
- B) There is a wide margin of safety.
- C) The drug requires frequent monitoring for toxicity.
- D) The drug is ineffective.
Correct Answer: B) There is a wide margin of safety.
Rationale: A high therapeutic index indicates a large
difference between therapeutic and toxic doses, suggesting
a safer drug profile.
### Fill-in-the-Blank Questions
6. The _______ is the study of the biological effects of
drugs on the body.
Correct Answer: Pharmacodynamics
Rationale: Pharmacodynamics refers to how a drug
affects biological systems.
7. The _______ of a drug is defined as the time it takes for
its concentration in the bloodstream to reduce to half its
original value.
Correct Answer: half-life
©2024/2025
Pharmacology
READINESS EXAM GUIDE
Q&S
©2024/2025
,1. Which of the following is primarily responsible for the
metabolism of drugs?
- A) Liver
- B) Kidney
- C) Intestines
- D) Lungs
Correct Answer: A) Liver
Rationale: The liver contains enzymes that metabolize
drugs, particularly through the cytochrome P450 system.
2. Which of the following pharmacokinetic processes
refers to the movement of drugs into the bloodstream?
- A) Distribution
- B) Absorption
- C) Metabolism
- D) Excretion
Correct Answer: B) Absorption
Rationale: Absorption is the process through which
drugs enter the systemic circulation.
3. What is the term for the dosage of a drug that produces
a therapeutic effect in 50% of the population?
- A) LD50
- B) ED50
- C) TD50
- D) IC50
Correct Answer: B) ED50
Rationale: The ED50 (effective dose 50) is the dose
required to elicit a therapeutic response in half of a tested
population.
4. Which of the following drug routes would avoid first-
©2024/2025
, pass metabolism?
- A) Oral
- B) Intravenous
- C) Subcutaneous
- D) Rectal
Correct Answer: B) Intravenous
Rationale: Intravenous administration delivers drugs
directly into the bloodstream, bypassing the first-pass
metabolism that occurs in the liver.
5. A patient is administered a drug with a high therapeutic
index. Which of the following statements is true?
- A) The drug is highly lethal.
- B) There is a wide margin of safety.
- C) The drug requires frequent monitoring for toxicity.
- D) The drug is ineffective.
Correct Answer: B) There is a wide margin of safety.
Rationale: A high therapeutic index indicates a large
difference between therapeutic and toxic doses, suggesting
a safer drug profile.
### Fill-in-the-Blank Questions
6. The _______ is the study of the biological effects of
drugs on the body.
Correct Answer: Pharmacodynamics
Rationale: Pharmacodynamics refers to how a drug
affects biological systems.
7. The _______ of a drug is defined as the time it takes for
its concentration in the bloodstream to reduce to half its
original value.
Correct Answer: half-life
©2024/2025
