PHM Exam Questions And Accurate Answers
Your Patient Was Diagnosed as having Alzheimers disease a couple of years ago and
you have prescribed medication to treat the disease since that time. Today, his
caregiver has called you requesting a repeat prescription. Without looking at your
patients record, you appropriately prescribe: - Answer Donepezil (ARICEPT)
After release from an axon terminal of a cholinergic neuron, acetylcholine is... - Answer
Broken down by acetylcholine esterase in the synaptic gap
A drug is totally eliminated by excretion in the urine. Which of the following will produce
an increase of concentration of free drug in the plasma? - Answer A reabsorption of
drug from the renal tubual and displacement of drug from plasma protein (albumin)
binding sites
A drug which is a substrate for cholinesterase's , and although it does not affect salivary
secretion, it does activate cholinergic receptors at the skeletal neuromuscular junction:
- Answer Succinylcholine (ANECTINE)
When two drugs, Drug A and Drug B, which are both substrates for the same
drug-metabolizing enzyme are present: - Answer The change of rate of metabolism of
Drug B (compared to the rate of metabolism when only Drug B is present) depends on
the turnover rate (rate at which molecules are metabolized once bound to enzyme) of
Drugs A and B
Urinary Incontinence resulting from overactivity of the muscle of the wall of the urinary
bladder is appropriately treated with: - Answer Tolterodine (DETROL)
The liver enzyme Enzyme Z metabolizes Drug A. If drug A is administered repeatedly,
then the amount of Enzyme Z in the liver is increased... Consequently - Answer The half
life of Drug B also metabolized by Enzyme Z will be decreased
, Isoptoterenol (ISUPREL) will tend to decrease blood pressure by: - Answer Activation of
beta2 adrenoreceptors on the blood vessels of skeletal muscle
If the volume of distribution of a drug is calculated to be the same as plasma volume
then one should conclude that: - Answer the drug did not leave systemic circulation
Anticholinesterase (aka Cholinesterase inhibitors): - Answer Intensify and prolong the
actions of physiologically released acetylcholine & reverse the effects of atropine
(ATREZA,SAL-TROPIN) have effects where either nicotinic and muscarinic receptors
are present
The therapeutic threshold concentration (aka minimal effective concentration) of a
drug: - Answer Likely reflects the affinity of the drug for the receptors through which it
produces therapeutic effects
Labetolol is an antagonist at: - Answer beta1, beta2, alpha1 adrenergic receptors
The duration of action of a drug given a single dose (assuming the drug must enter the
blood to have action) - Answer is independent of the latency to action for the drug
Atenolol (TENORMIN) can be used as an antihypertensive agent because atenolol: -
Answer Reduces cardiac output through its actions within the heart
Atracurium (TACURIUM): - Answer is a competitive antagonist at nicotonic receptors at
the skeletal neuromuscular junction& causes muscle weakness by a different
mechanism than succinylcholine (ANECTINE)
An expected side effect when using systemically administered bethanechol
(URECHOLINE) to treat atony of the urinary bladder after childbirth: - Answer Reduced
heart rate (bradycardia) and Decreased blood pressure resulting from vasodilation of
some blood vessels
A drug which is a substrate for cholinesterase's increases salivary secretion, and will
Your Patient Was Diagnosed as having Alzheimers disease a couple of years ago and
you have prescribed medication to treat the disease since that time. Today, his
caregiver has called you requesting a repeat prescription. Without looking at your
patients record, you appropriately prescribe: - Answer Donepezil (ARICEPT)
After release from an axon terminal of a cholinergic neuron, acetylcholine is... - Answer
Broken down by acetylcholine esterase in the synaptic gap
A drug is totally eliminated by excretion in the urine. Which of the following will produce
an increase of concentration of free drug in the plasma? - Answer A reabsorption of
drug from the renal tubual and displacement of drug from plasma protein (albumin)
binding sites
A drug which is a substrate for cholinesterase's , and although it does not affect salivary
secretion, it does activate cholinergic receptors at the skeletal neuromuscular junction:
- Answer Succinylcholine (ANECTINE)
When two drugs, Drug A and Drug B, which are both substrates for the same
drug-metabolizing enzyme are present: - Answer The change of rate of metabolism of
Drug B (compared to the rate of metabolism when only Drug B is present) depends on
the turnover rate (rate at which molecules are metabolized once bound to enzyme) of
Drugs A and B
Urinary Incontinence resulting from overactivity of the muscle of the wall of the urinary
bladder is appropriately treated with: - Answer Tolterodine (DETROL)
The liver enzyme Enzyme Z metabolizes Drug A. If drug A is administered repeatedly,
then the amount of Enzyme Z in the liver is increased... Consequently - Answer The half
life of Drug B also metabolized by Enzyme Z will be decreased
, Isoptoterenol (ISUPREL) will tend to decrease blood pressure by: - Answer Activation of
beta2 adrenoreceptors on the blood vessels of skeletal muscle
If the volume of distribution of a drug is calculated to be the same as plasma volume
then one should conclude that: - Answer the drug did not leave systemic circulation
Anticholinesterase (aka Cholinesterase inhibitors): - Answer Intensify and prolong the
actions of physiologically released acetylcholine & reverse the effects of atropine
(ATREZA,SAL-TROPIN) have effects where either nicotinic and muscarinic receptors
are present
The therapeutic threshold concentration (aka minimal effective concentration) of a
drug: - Answer Likely reflects the affinity of the drug for the receptors through which it
produces therapeutic effects
Labetolol is an antagonist at: - Answer beta1, beta2, alpha1 adrenergic receptors
The duration of action of a drug given a single dose (assuming the drug must enter the
blood to have action) - Answer is independent of the latency to action for the drug
Atenolol (TENORMIN) can be used as an antihypertensive agent because atenolol: -
Answer Reduces cardiac output through its actions within the heart
Atracurium (TACURIUM): - Answer is a competitive antagonist at nicotonic receptors at
the skeletal neuromuscular junction& causes muscle weakness by a different
mechanism than succinylcholine (ANECTINE)
An expected side effect when using systemically administered bethanechol
(URECHOLINE) to treat atony of the urinary bladder after childbirth: - Answer Reduced
heart rate (bradycardia) and Decreased blood pressure resulting from vasodilation of
some blood vessels
A drug which is a substrate for cholinesterase's increases salivary secretion, and will
