PHM 714 Exam 3 Questions With Accurate Answers
__________ binds to high-affinity Cupric (Cu2+) transporter (CTR1 also called as
SLC31A1) - Answer Oxaliplatin
Bevacizumab inhibits the progression of cancer cells by inhibiting ________ - Answer
VEGF (Vascular endothelial growth factor)
Afilbercept inhibits the progression of cancer cells by ________ (multi-select)
acting as a soluble receptor that binds to VEGF receptor ligands
TRK A, B and C
acting as a trap for VEGF receptor ligands
BRAF V600 E mutation - Answer acting as a soluble receptor that binds to VEGF
receptor ligands
acting as a trap for VEGF receptor ligands
Ramucirumab inhibits the progression of cancer cells by ________ - Answer binding to
VEGFR2
Irinotecan is converted to SN38 (active metabolite) by _________ - Answer
Carboxylesterase
Irinotecan is glucuronidated by_______ to SN38 G (inactive metabolite) which is secreted
in bile and urine (multi-select)
UGT1A1
,Topoisomerase I
UGT1A7
Carboxylesterase - Answer UGT1A1
UGT1A7
Irinotecan is known to cause severe toxicity to cancer patients with Gilbert's syndrome.
Gilbert's syndrome is characterized by the presence of __________ - Answer UGT1A1*28
__________ is known to cause severe diarrhea and bone marrow suppression - Answer
Irinotecan
Thymidylate synthase (TS) an enzyme that forms a complex with _________ and
__________ and aids in DNA chain elongation - Answer dUMP and NN methylene FH4
______ inhibits the formation of complex of TS with dUMP & NN methylene FH4 to stop
DNA chain elongation (multi-select)
Cisplatin
Cetuximab
Fluorouracil (5-FU)
Capecitabine (Prodrug) - Answer Fluorouracil (5-FU)
Capecitabine (Prodrug)
______ inhibits the binding of CTLA4 (on TC) with B7 (on APC) and inhibits the T cell
priming to kill the cancer cells - Answer Ipilimumab
___________ is an inhibitor of the tropomyosin receptor kinases (TRK), TRKA, TRKB, and
TRKC and is metabolized by CYP3A4 - Answer Entrectinib
, Mutations in TS can cause resistance to _________ - Answer 5-FU
Capecitabine and fluorouracil are classified as ___________. - Answer antimetabolites
Which of the following adverse drug reaction is associated with Vemurafinib? (Select all
that apply)
Hepatotoxicity
Skin reactions
QT prolongation
Squamous cell carcinoma - Answer Hepatotoxicity
Skin reactions
QT prolongation
Squamous cell carcinoma
Nivolumab and and pembrolizumab inhibit the binding of ________ (on T cells) with
________ (on APC) - Answer PD-1
PD-L1
Deficiency of DPD (dihydropyrimidine dehydrogenase) enzyme may _________ 5FU
sensitivity in patients - Answer increase
Vemurafenib is active against ________ mutations - Answer BRAF V600 E
Larotrectinib is an inhibitor of cupric transporter.
T/F? - Answer False
__________ binds to high-affinity Cupric (Cu2+) transporter (CTR1 also called as
SLC31A1) - Answer Oxaliplatin
Bevacizumab inhibits the progression of cancer cells by inhibiting ________ - Answer
VEGF (Vascular endothelial growth factor)
Afilbercept inhibits the progression of cancer cells by ________ (multi-select)
acting as a soluble receptor that binds to VEGF receptor ligands
TRK A, B and C
acting as a trap for VEGF receptor ligands
BRAF V600 E mutation - Answer acting as a soluble receptor that binds to VEGF
receptor ligands
acting as a trap for VEGF receptor ligands
Ramucirumab inhibits the progression of cancer cells by ________ - Answer binding to
VEGFR2
Irinotecan is converted to SN38 (active metabolite) by _________ - Answer
Carboxylesterase
Irinotecan is glucuronidated by_______ to SN38 G (inactive metabolite) which is secreted
in bile and urine (multi-select)
UGT1A1
,Topoisomerase I
UGT1A7
Carboxylesterase - Answer UGT1A1
UGT1A7
Irinotecan is known to cause severe toxicity to cancer patients with Gilbert's syndrome.
Gilbert's syndrome is characterized by the presence of __________ - Answer UGT1A1*28
__________ is known to cause severe diarrhea and bone marrow suppression - Answer
Irinotecan
Thymidylate synthase (TS) an enzyme that forms a complex with _________ and
__________ and aids in DNA chain elongation - Answer dUMP and NN methylene FH4
______ inhibits the formation of complex of TS with dUMP & NN methylene FH4 to stop
DNA chain elongation (multi-select)
Cisplatin
Cetuximab
Fluorouracil (5-FU)
Capecitabine (Prodrug) - Answer Fluorouracil (5-FU)
Capecitabine (Prodrug)
______ inhibits the binding of CTLA4 (on TC) with B7 (on APC) and inhibits the T cell
priming to kill the cancer cells - Answer Ipilimumab
___________ is an inhibitor of the tropomyosin receptor kinases (TRK), TRKA, TRKB, and
TRKC and is metabolized by CYP3A4 - Answer Entrectinib
, Mutations in TS can cause resistance to _________ - Answer 5-FU
Capecitabine and fluorouracil are classified as ___________. - Answer antimetabolites
Which of the following adverse drug reaction is associated with Vemurafinib? (Select all
that apply)
Hepatotoxicity
Skin reactions
QT prolongation
Squamous cell carcinoma - Answer Hepatotoxicity
Skin reactions
QT prolongation
Squamous cell carcinoma
Nivolumab and and pembrolizumab inhibit the binding of ________ (on T cells) with
________ (on APC) - Answer PD-1
PD-L1
Deficiency of DPD (dihydropyrimidine dehydrogenase) enzyme may _________ 5FU
sensitivity in patients - Answer increase
Vemurafenib is active against ________ mutations - Answer BRAF V600 E
Larotrectinib is an inhibitor of cupric transporter.
T/F? - Answer False
